7VKM

Crystal structure of TrkA (G595R) kinase domain

Summary for 7VKM

• Entry DOI: 10.2210/pdb7vkm/pdb
• Descriptor: Tyrosine-protein kinase receptor (2 entities in total)
• Functional Keywords: trk, ntrk, macrocyclic inhibitor, drug resistance, repotrectinib, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 37335.92

Authors

Murray, B.W.,Rogers, E.,Zhai, D.,Deng, W.,Chen, X.,Sprengeler, P.A.,Zhang, X.,Graber, A.,Reich, S.H.,Stopatschinskaja, S.,Solomon, B.,Besse, B.,Drilon, A. (deposition date: 2021-09-30, release date: 2021-10-13, Last modification date: 2023-11-29)

• Primary citation: Murray, B.W.,Rogers, E.,Zhai, D.,Deng, W.,Chen, X.,Sprengeler, P.A.,Zhang, X.,Graber, A.,Reich, S.H.,Stopatschinskaja, S.,Solomon, B.,Besse, B.,Drilon, A.; Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations.; Mol.Cancer Ther., 20:2446-2456, 2021; PubMed: 34625502; DOI: 10.1158/1535-7163.MCT-21-0632

Experimental method

X-RAY DIFFRACTION (2.55 Å)