3VFE
 
 | | Virtual Screening and X-Ray Crystallography for Human Kallikrein 6 Inhibitors with an Amidinothiophene P1 Group | | 分子名称: | 4-{[(3R)-3-{[(7-methoxynaphthalen-2-yl)sulfonyl](thiophen-3-ylmethyl)amino}-2-oxopyrrolidin-1-yl]methyl}thiophene-2-carboximidamide, Kallikrein-6 | | 著者 | Chen, X, Zhang, Y, Xia, T, Wang, R. | | 登録日 | 2012-01-09 | | 公開日 | 2012-11-21 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Virtual Screening and X-ray Crystallography for Human Kallikrein 6 Inhibitors with an Amidinothiophene P1 Group.
Acs Med.Chem.Lett., 3, 2012
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1J51
 | | CRYSTAL STRUCTURE OF CYTOCHROME P450CAM MUTANT (F87W/Y96F/V247L/C334A) WITH 1,3,5-TRICHLOROBENZENE | | 分子名称: | 1,3,5-TRICHLORO-BENZENE, CYTOCHROME P450CAM, POTASSIUM ION, ... | | 著者 | Chen, X, Christopher, A, Jones, J, Guo, Q, Xu, F, Cao, R, Wong, L.L, Rao, Z. | | 登録日 | 2002-01-05 | | 公開日 | 2002-01-23 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of the F87W/Y96F/V247L mutant of cytochrome P-450cam with 1,3,5-trichlorobenzene bound and further protein engineering for the oxidation of pentachlorobenzene and hexachlorobenzene
J.BIOL.CHEM., 277, 2002
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1JX6
 | | CRYSTAL STRUCTURE OF LUXP FROM VIBRIO HARVEYI COMPLEXED WITH AUTOINDUCER-2 | | 分子名称: | 3A-METHYL-5,6-DIHYDRO-FURO[2,3-D][1,3,2]DIOXABOROLE-2,2,6,6A-TETRAOL, CALCIUM ION, LUXP PROTEIN | | 著者 | Chen, X, Schauder, S, Potier, N, Van Dorsselaer, A, Pelczer, I, BassleR, B.L, Hughson, F.M. | | 登録日 | 2001-09-05 | | 公開日 | 2002-02-04 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural identification of a bacterial quorum-sensing signal containing boron.
Nature, 415, 2002
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3B3Q
 | | Crystal structure of a synaptic adhesion complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Chen, X, Liu, H, Shim, A, Focia, P, He, X. | | 登録日 | 2007-10-22 | | 公開日 | 2008-01-15 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions.
Nat.Struct.Mol.Biol., 15, 2008
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6V0V
 | | Cryo-EM structure of mouse WT RAG1/2 NFC complex (DNA0) | | 分子名称: | CALCIUM ION, DNA (30-MER), V(D)J recombination-activating protein 1, ... | | 著者 | Chen, X, Yang, W, Gellert, M. | | 登録日 | 2019-11-19 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | | 主引用文献 | Cutting antiparallel DNA strands in a single active site.
Nat.Struct.Mol.Biol., 27, 2020
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4QDJ
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4QDK
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6U19
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8KFD
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474D
 | | A NOVEL END-TO-END BINDING OF TWO NETROPSINS TO THE DNA DECAMER D(CCCCCIIIII)2 | | 分子名称: | DNA (5'-D(*CP*CP*CP*(CBR)P*CP*IP*IP*IP*IP*I)-3'), NETROPSIN | | 著者 | Chen, X, Rao, S.T, Sekar, K, Sundaralingam, M. | | 登録日 | 1998-01-14 | | 公開日 | 1998-12-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | A novel end-to-end binding of two netropsins to the DNA decamers d(CCCCCIIIII)2, d(CCCBr5CCIIIII)2and d(CBr5CCCCIIIII)2.
Nucleic Acids Res., 26, 1998
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6IGA
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6IG5
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8GRD
 | | Crystal structure of a constitutively active mutant of the alpha beta heterodimer of human IDH3 in complex with ADP and Mg | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, ... | | 著者 | Chen, X, Sun, P, Ding, J. | | 登録日 | 2022-09-01 | | 公開日 | 2022-11-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.699 Å) | | 主引用文献 | Structures of a constitutively active mutant of human IDH3 reveal new insights into the mechanisms of allosteric activation and the catalytic reaction.
J.Biol.Chem., 298, 2022
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6CIJ
 | | Cryo-EM structure of mouse RAG1/2 HFC complex containing partial HMGB1 linker(3.9 A) | | 分子名称: | CALCIUM ION, DNA (30-MER), DNA (41-MER), ... | | 著者 | Chen, X, Kim, M, Chuenchor, W, Cui, Y, Zhang, X, Zhou, Z.H, Gellert, M, Yang, W. | | 登録日 | 2018-02-24 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cracking the DNA Code for V(D)J Recombination.
Mol. Cell, 70, 2018
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8HHX
 | | SARS-CoV-2 Delta Spike in complex with FP-12A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FP-12A Fab heavy chain, ... | | 著者 | Chen, X, Wu, Y.-M. | | 登録日 | 2022-11-17 | | 公開日 | 2023-02-01 | | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | | 主引用文献 | Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2.
Nat Commun, 14, 2023
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6CG0
 | | Cryo-EM structure of mouse RAG1/2 HFC complex (3.17 A) | | 分子名称: | CALCIUM ION, DNA (30-MER), DNA (41-MER), ... | | 著者 | Chen, X, Kim, M, Chuenchor, W, Cui, Y, Zhang, X, Zhou, Z.H, Gellert, M, Yang, W. | | 登録日 | 2018-02-19 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | | 主引用文献 | Cracking the DNA Code for V(D)J Recombination.
Mol. Cell, 70, 2018
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159D
 | | SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX | | 分子名称: | DISTAMYCIN A, DNA (5'-D(*IP*CP*IP*CP*IP*CP*IP*C)-3'), MAGNESIUM ION | | 著者 | Chen, X, Ramakrishnan, B, Rao, S.T, Sundaralingam, M. | | 登録日 | 1994-02-10 | | 公開日 | 1995-02-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Binding of two distamycin A molecules in the minor groove of an alternating B-DNA duplex.
Nat.Struct.Biol., 1, 1994
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1DZL
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6DUP
 | | CRYSTAL STRUCTURE OF PXR IN COMPLEX WITH COMPOUND 7 | | 分子名称: | (2S)-2-({[3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]oxy}methyl)-2,3-dihydro-7H-[1,3]oxazolo[3,2-a]pyrimidin-7-one, Nuclear receptor subfamily 1 group I member 2 | | 著者 | Chen, X, Zhang, Y, Mclean, L.R. | | 登録日 | 2018-06-21 | | 公開日 | 2018-08-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Amelioration of PXR-mediated CYP3A4 induction by mGluR2 modulators.
Bioorg. Med. Chem. Lett., 28, 2018
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1EGA
 | | CRYSTAL STRUCTURE OF A WIDELY CONSERVED GTPASE ERA | | 分子名称: | PROTEIN (GTP-BINDING PROTEIN ERA), SULFATE ION | | 著者 | Chen, X, Ji, X. | | 登録日 | 1998-12-01 | | 公開日 | 1999-07-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of ERA: a GTPase-dependent cell cycle regulator containing an RNA binding motif.
Proc.Natl.Acad.Sci.USA, 96, 1999
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3EJJ
 | | Structure of M-CSF bound to the first three domains of FMS | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Colony stimulating factor-1, Macrophage colony-stimulating factor 1 receptor | | 著者 | Chen, X, Liu, H, Focia, P.J, Shim, A, He, X. | | 登録日 | 2008-09-18 | | 公開日 | 2008-12-09 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases.
Proc.Natl.Acad.Sci.USA, 105, 2008
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5DIP
 | | Crystal structure of lpg0406 in reduced form from Legionella pneumophila | | 分子名称: | Alkyl hydroperoxide reductase AhpD, GLYCEROL, SODIUM ION | | 著者 | Chen, X, Gong, X, Zhang, N, Ge, H. | | 登録日 | 2015-09-01 | | 公開日 | 2015-10-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.097 Å) | | 主引用文献 | Structure of lpg0406, a carboxymuconolactone decarboxylase family protein possibly involved in antioxidative response from Legionella pneumophila
Protein Sci., 24, 2015
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5DIK
 | | Crystal structure of apo-lpg0406, a carboxymuconolactone decarboxylase family protein from Legionella pneumophila | | 分子名称: | Alkyl hydroperoxide reductase AhpD | | 著者 | Chen, X, Gong, X, Zhang, N, Ge, H. | | 登録日 | 2015-09-01 | | 公開日 | 2015-10-14 | | 最終更新日 | 2016-01-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of lpg0406, a carboxymuconolactone decarboxylase family protein possibly involved in antioxidative response from Legionella pneumophila
Protein Sci., 24, 2015
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3LUT
 | | A Structural Model for the Full-length Shaker Potassium Channel Kv1.2 | | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, Potassium voltage-gated channel subfamily A member 2, ... | | 著者 | Chen, X, Ni, F, Wang, Q, Ma, J. | | 登録日 | 2010-02-18 | | 公開日 | 2010-06-23 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement.
Proc.Natl.Acad.Sci.USA, 107, 2010
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6JPE
 | | Crystal structure of FGFR4 kinase domain with irreversible inhibitor 1 | | 分子名称: | Fibroblast growth factor receptor 4, N-[2-[[6-[2-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]amino]pyridin-3-yl]pyrimidin-4-yl]amino]-3-methyl-phenyl]prop-2-enamide, SULFATE ION | | 著者 | Chen, X, Dai, S, Zhou, Z, Chen, Y. | | 登録日 | 2019-03-26 | | 公開日 | 2020-05-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | | 主引用文献 | Development of a Potent and Specific FGFR4 Inhibitor for the Treatment of Hepatocellular Carcinoma.
J.Med.Chem., 63, 2020
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