6JPE

Crystal structure of FGFR4 kinase domain with irreversible inhibitor 1

Summary for 6JPE

Entry DOI	10.2210/pdb6jpe/pdb
Descriptor	Fibroblast growth factor receptor 4, N-[2-[[6-[2-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]amino]pyridin-3-yl]pyrimidin-4-yl]amino]-3-methyl-phenyl]prop-2-enamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	fgfr4, irreversible inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35406.54
Authors	Chen, X.,Dai, S.,Zhou, Z.,Chen, Y. (deposition date: 2019-03-26, release date: 2020-05-06, Last modification date: 2023-11-22)
Primary citation	Rezende Miranda, R.,Fu, Y.,Chen, X.,Perino, J.,Cao, P.,Carpten, J.,Chen, Y.,Zhang, C. Development of a Potent and Specific FGFR4 Inhibitor for the Treatment of Hepatocellular Carcinoma. J.Med.Chem., 63:11484-11497, 2020 Cited by PubMed: 33030342 DOI: 10.1021/acs.jmedchem.0c00044 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.601 Å)

Structure validation