6JPE

Crystal structure of FGFR4 kinase domain with irreversible inhibitor 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue BYU A 801

Chain	Residue
A	LEU473
A	ALA553
A	GLY556
A	LEU619
A	ALA629
A	ASP630
A	PHE631
A	HOH1025
A	VAL481
A	ARG483
A	LYS503
A	GLU520
A	MET524
A	VAL550
A	GLU551
A	CYS552

---

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 802

Chain	Residue
A	ARG616
A	THR646
A	ASN648
A	ARG650
A	HOH919
A	HOH979
A	HOH1057

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 803

Chain	Residue
A	ARG563
A	ARG566
A	SER688
A	HOH906
A	HOH908

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVrAeafgmdparpdqast...VAVK

Chain	Residue	Details
A	LEU473-LYS503

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV

Chain	Residue	Details
A	CYS608-VAL620

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"18670643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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