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PDB: 550 件
4OIV
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Structural basis for small molecule NDB as a selective antagonist of FXR
分子名称: Bile acid receptor, N-benzyl-N-(3-tert-butyl-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino)benzamide
著者Xu, X, Chen, L, Hu, L, Shen, X.
登録日2014-01-20
公開日2015-03-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor alpha (FXR alpha ) in Stabilizing the Homodimerization of the Receptor.
J.Biol.Chem., 290, 2015
1RYQ
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BU of 1ryq by Molmil
Putative DNA-directed RNA polymerase, subunit e'' from Pyrococcus Furiosus Pfu-263306-001
分子名称: DNA-directed RNA polymerase, subunit e'', ZINC ION
著者Liu, Z.-J, Chen, L, Tempel, W, Shah, A, Arendall III, W.B, Rose, J.P, Brereton, P.S, Izumi, M, Jenney Jr, F.E, Lee, H.S, Poole II, F.L, Shah, C, Sugar, F.J, Adams, M.W.W, Richardson, D.C, Richardson, J.S, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG)
登録日2003-12-22
公開日2004-08-10
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Parameter-space screening: a powerful tool for high-throughput crystal structure determination.
Acta Crystallogr.,Sect.D, 61, 2005
3SQ6
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BU of 3sq6 by Molmil
Crystal Structures of the Ligand Binding Domain of a Pentameric Alpha7 Nicotinic Receptor Chimera with its Agonist Epibatidine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, EPIBATIDINE, ...
著者Li, S.-X, Huang, S, Bren, N, Noridomi, K, Dellisanti, C, Sine, S, Chen, L.
登録日2011-07-05
公開日2011-09-28
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Ligand-binding domain of an alpha 7-nicotinic receptor chimera and its complex with agonist.
Nat.Neurosci., 14, 2011
3SQ9
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Crystal Structures of the Ligand Binding Domain of a Pentameric Alpha7 Nicotinic Receptor Chimera
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Neuronal acetylcholine receptor subunit alpha-7, ...
著者Li, S.-X, Huang, S, Bren, N, Noridomi, K, Dellisanti, C, Sine, S, Chen, L.
登録日2011-07-05
公開日2011-09-28
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Ligand-binding domain of an alpha 7-nicotinic receptor chimera and its complex with agonist.
Nat.Neurosci., 14, 2011
6C9L
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BU of 6c9l by Molmil
MEF2B Apo Protein Structure
分子名称: Myocyte-specific enhancer factor 2B
著者Lei, X, Chen, L.
登録日2018-01-26
公開日2018-02-07
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of Apo MEF2B Reveals New Insights in DNA Binding and Cofactor Interaction.
Biochemistry, 57, 2018
6BZ1
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BU of 6bz1 by Molmil
MEF2 Chimera D83V mutant/DNA complex
分子名称: DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(P*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), MEF2 CHIMERA
著者Lei, X, Chen, L.
登録日2017-12-21
公開日2018-02-07
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.97 Å)
主引用文献The Cancer Mutation D83V Induces an alpha-Helix to beta-Strand Conformation Switch in MEF2B.
J. Mol. Biol., 430, 2018
6BYY
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MEF2 CHIMERA/DNA Complex
分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 3,3',3''-phosphanetriyltripropanoic acid, DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), ...
著者Lei, X, Chen, L.
登録日2017-12-21
公開日2018-01-31
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Cancer Mutation D83V Induces an alpha-Helix to beta-Strand Conformation Switch in MEF2B.
J. Mol. Biol., 430, 2018
3WMB
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BU of 3wmb by Molmil
Crystal structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with naphthalimide derivative Q1
分子名称: 2-(2-{[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]amino}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-hexosaminidase
著者Liu, T, Zhou, Y, Chen, L, Yang, Q.
登録日2013-11-16
公開日2014-11-05
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two beta-GlcNAcase homologs
Sci Rep, 4, 2014
3WZF
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BU of 3wzf by Molmil
Crystal structure of human cytoplasmic aspartate aminotransferase
分子名称: Aspartate aminotransferase, cytoplasmic
著者Jiang, X, Chang, H, Zhou, Y, Chen, L, Yang, Q.
登録日2014-09-24
公開日2015-10-07
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.991 Å)
主引用文献Recombinant expression, purification and Preliminary crystallographic studies of human cytoplasmic aspartate aminotransferase
To be Published
7XA3
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BU of 7xa3 by Molmil
Cryo-EM structure of the CCL2 bound CCR2-Gi complex
分子名称: C-C motif chemokine 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H.
登録日2022-03-17
公開日2022-08-24
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3.
Cell Discov, 8, 2022
7X9Y
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Cryo-EM structure of the apo CCR3-Gi complex
分子名称: C-C chemokine receptor type 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H.
登録日2022-03-16
公開日2022-08-24
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3.
Cell Discov, 8, 2022
4R4Z
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BU of 4r4z by Molmil
Structure of PNGF-II in P21 space group
分子名称: PNGF-II
著者Sun, G, Yu, X, Celimuge, Wang, L, Li, M, Gan, J, Qu, D, Ma, J, Chen, L.
登録日2014-08-20
公開日2015-01-28
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Identification and Characterization of a Novel Prokaryotic Peptide: N-glycosidase from Elizabethkingia meningoseptica
J.Biol.Chem., 2015
4R4X
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Structure of PNGF-II in C2 space group
分子名称: PNGF-II, ZINC ION
著者Sun, G, Yu, X, Celimuge, Wang, L, Li, M, Gan, J, Qu, D, Ma, J, Chen, L.
登録日2014-08-20
公開日2015-01-28
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Identification and Characterization of a Novel Prokaryotic Peptide: N-glycosidase from Elizabethkingia meningoseptica
J.Biol.Chem., 2015
8IA7
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BU of 8ia7 by Molmil
Structural insights into human brain gut peptide cholecystokinin receptors
分子名称: CCK-8, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S.
登録日2023-02-08
公開日2023-12-06
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into human brain-gut peptide cholecystokinin receptors.
Cell Discov, 8, 2022
4YOM
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BU of 4yom by Molmil
Structure of SAD kinase
分子名称: 1,2-ETHANEDIOL, Serine/threonine-protein kinase BRSK2
著者Wu, J.X, Wang, J, Chen, L, Wang, Z.X, Wu, J.W.
登録日2015-03-12
公開日2015-12-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structural insight into the mechanism of synergistic autoinhibition of SAD kinases
Nat Commun, 6, 2015
4YNZ
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BU of 4ynz by Molmil
Structure of the N-terminal domain of SAD
分子名称: Serine/threonine-protein kinase BRSK2
著者Wu, J.X, Wang, J, Chen, L, Wang, Z.X, Wu, J.W.
登録日2015-03-11
公開日2015-12-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural insight into the mechanism of synergistic autoinhibition of SAD kinases
Nat Commun, 6, 2015
4EWE
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BU of 4ewe by Molmil
Study on structure and function relationships in human Pirin with Manganese ion
分子名称: 1,2-ETHANEDIOL, MANGANESE (II) ION, Pirin
著者Liu, F, Rehmani, I, Fu, R, Esaka, S, Chen, L, Serrano, V, Liu, A.
登録日2012-04-26
公開日2013-05-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
4EWD
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BU of 4ewd by Molmil
Study on structure and function relationships in human Pirin with Mn ion
分子名称: MANGANESE (II) ION, Pirin
著者Liu, F, Rehmani, I, Chen, L, Fu, R, Serrano, V, Wilson, D.W, Liu, A.
登録日2012-04-26
公開日2013-05-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
4ERO
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BU of 4ero by Molmil
Study on structure and function relationships in human Pirin with Cobalt ion
分子名称: 1,2-ETHANEDIOL, COBALT (II) ION, Pirin
著者Liu, F, Rehmani, I, Fu, R, Esaka, S, Chen, L, Serrano, V, Liu, A.
登録日2012-04-20
公開日2013-05-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
4EWA
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BU of 4ewa by Molmil
Study on structure and function relationships in human Pirin with Fe ion
分子名称: FE (III) ION, Pirin
著者Liu, F, Rehmani, I, Chen, L, Fu, R, Serrano, V, Wilson, D.W, Liu, A.
登録日2012-04-26
公開日2013-05-29
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
7Z8O
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Crystal structure of SARS-CoV-2 S RBD in complex with a stapled peptide
分子名称: 2,4,6-tris(chloromethyl)-1,3,5-triazine, GLYCEROL, Spike protein S1, ...
著者Brear, P, Chen, L, Gaynor, K, Harman, M, Dods, R, Hyvonen, M.
登録日2022-03-18
公開日2023-06-28
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (0.96 Å)
主引用文献Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.
Nat Commun, 14, 2023
8AAA
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BU of 8aaa by Molmil
Crystal structure of SARS-CoV-2 S RBD in complex with a stapled peptide
分子名称: 1,1',1''-(1,3,5-triazinane-1,3,5-triyl)tripropan-1-one, Spike protein S1, Stapled peptide
著者Brear, P, Chen, L, Gaynor, K, Harman, M, Dods, R, Hyvonen, M.
登録日2022-06-30
公開日2023-06-28
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.
Nat Commun, 14, 2023
3CX9
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Crystal Structure of Human serum albumin complexed with Myristic acid and lysophosphatidylethanolamine
分子名称: (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, MYRISTIC ACID, Serum albumin
著者Guo, S, Yang, F, Chen, L, Bian, C, Huang, M.
登録日2008-04-24
公開日2009-04-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis of transport of lysophospholipids by human serum albumin.
Biochem.J., 423, 2009
3CQ2
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Structure of the DTDP-4-Keto-L-Rhamnose Reductase related protein (other form) from Thermus Thermophilus HB8
分子名称: Putative uncharacterized protein TTHB138
著者Jeyakanthan, J, Kanaujia, S.P, Sekar, K, Satoh, S, Kitamura, Y, Ebihara, A, Chen, L, Liu, Z.J, Wang, B.C, Yokoyama, S, Kuramitsu, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2008-04-02
公開日2009-04-07
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the DTDP-4-Keto-L-Rhamnose Reductase related protein from Thermus Thermophilus HB8
To be Published
3DAE
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BU of 3dae by Molmil
Crystal structure of phosphorylated SNF1 kinase domain
分子名称: Carbon catabolite-derepressing protein kinase
著者Zheng, L.-S, Chen, L, Jiao, Z.-H, Wu, J.-W.
登録日2008-05-29
公開日2009-06-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.899 Å)
主引用文献Structural insight into the autoinhibition mechanism of AMP-activated protein kinase
Nature, 459, 2009

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