MEF2 Chimera D83V mutant/DNA complex

Summary for 6BZ1

DescriptorMEF2 CHIMERA, DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(P*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3') (3 entities in total)
Functional Keywordsmef2, transcription factor, d83v mutant, conformation switch, transcription-dna complex, transcription/dna
Biological sourceHomo sapiens (Human)
Total number of polymer chains8
Total molecular weight63028.56
Lei, X.,Chen, L. (deposition date: 2017-12-21, release date: 2018-02-07, Last modification date: 2019-12-18)
Primary citation
Lei, X.,Kou, Y.,Fu, Y.,Rajashekar, N.,Shi, H.,Wu, F.,Xu, J.,Luo, Y.,Chen, L.
The Cancer Mutation D83V Induces an alpha-Helix to beta-Strand Conformation Switch in MEF2B.
J. Mol. Biol., 430:1157-1172, 2018
PubMed: 29477338 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2018.02.012
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.1985 0.3% 7.2% 0.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-25