7Z8O

Crystal structure of SARS-CoV-2 S RBD in complex with a stapled peptide

Summary for 7Z8O

• Entry DOI: 10.2210/pdb7z8o/pdb
• Descriptor: Spike protein S1, Stapled peptide, GLYCEROL, ... (5 entities in total)
• Functional Keywords: srbd, stapled peptide, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 2
• Total formula weight: 23973.19

Authors

Brear, P.,Chen, L.,Gaynor, K.,Harman, M.,Dods, R.,Hyvonen, M. (deposition date: 2022-03-18, release date: 2023-06-28, Last modification date: 2024-02-07)

• Primary citation: Gaynor, K.U.,Vaysburd, M.,Harman, M.A.J.,Albecka, A.,Jeffrey, P.,Beswick, P.,Papa, G.,Chen, L.,Mallery, D.,McGuinness, B.,Van Rietschoten, K.,Stanway, S.,Brear, P.,Lulla, A.,Ciazynska, K.,Chang, V.T.,Sharp, J.,Neary, M.,Box, H.,Herriott, J.,Kijak, E.,Tatham, L.,Bentley, E.G.,Sharma, P.,Kirby, A.,Han, X.,Stewart, J.P.,Owen, A.,Briggs, J.A.G.,Hyvonen, M.,Skynner, M.J.,James, L.C.; Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.; Nat Commun, 14:3583-3583, 2023; PubMed: 37328472; DOI: 10.1038/s41467-023-39158-1

Experimental method

X-RAY DIFFRACTION (0.96 Å)