5YWC
 
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5YW9
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5YWB
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5YW8
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5YWA
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7Y4S
 | | Structure of human MG53 homo-dimer | | Descriptor: | Tripartite motif-containing protein 72 | | Authors: | Chen, L, Niu, Y. | | Deposit date: | 2022-06-16 | | Release date: | 2022-09-21 | | Last modified: | 2023-04-05 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Cryo-EM structure of human MG53 homodimer.
Biochem.J., 479, 2022
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6JT0
 | | Structure of human soluble guanylate cyclase in the unliganded state | | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | | Deposit date: | 2019-04-08 | | Release date: | 2019-08-28 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural insights into the mechanism of human soluble guanylate cyclase.
Nature, 574, 2019
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6JT1
 | | Structure of human soluble guanylate cyclase in the heme oxidised state | | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | | Deposit date: | 2019-04-08 | | Release date: | 2019-08-28 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural insights into the mechanism of human soluble guanylate cyclase.
Nature, 574, 2019
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6L65
 | | Sirtuin 2 protein with H3K18 myristoylated peptide | | Descriptor: | MYRISTIC ACID, NAD-dependent protein deacetylase sirtuin-2, PRO-ARG-LYS-GLN-LEU, ... | | Authors: | Chen, L.F. | | Deposit date: | 2019-10-28 | | Release date: | 2020-11-04 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
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6L66
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7W4O
 | | The structure of KATP H175K mutant in pre-open state | | Descriptor: | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Chen, L, Wang, M. | | Deposit date: | 2021-11-28 | | Release date: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides.
Nat Commun, 13, 2022
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7W4P
 | | The structure of KATP H175K mutant in closed state | | Descriptor: | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Chen, L, Wang, M. | | Deposit date: | 2021-11-28 | | Release date: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides.
Nat Commun, 13, 2022
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6L72
 | | Sirtuin 2 demyristoylation native final product | | Descriptor: | NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-2,4-bis(oxidanyl)oxolan-3-yl] tetradecanoate | | Authors: | Chen, L.F. | | Deposit date: | 2019-10-30 | | Release date: | 2021-03-31 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.501 Å) | | Cite: | Sirtuin 2 protein with H3K18 myristoylated peptide
To Be Published
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6L71
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7WDB
 | | Human TRPC5 channel in complex with riluzole | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine, CALCIUM ION, ... | | Authors: | Chen, L, Wei, M, Yang, Y. | | Deposit date: | 2021-12-21 | | Release date: | 2022-04-13 | | Last modified: | 2022-08-03 | | Method: | ELECTRON MICROSCOPY (2.4 Å) | | Cite: | Structural identification of riluzole-binding site on human TRPC5.
Cell Discov, 8, 2022
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7WWG
 | | Crystal structure of Saccharomyces cerevisiae Sfh2 complexed with phosphatidylinositol in an open conformation | | Descriptor: | (1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Phosphatidylinositol transfer protein CSR1 | | Authors: | Chen, L, Tan, L, Im, Y.J. | | Deposit date: | 2022-02-12 | | Release date: | 2022-07-13 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
Acta Crystallogr D Struct Biol, 78, 2022
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7WWE
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7WWD
 | | Crystal structure of Saccharomyces cerevisiae Sfh2 complexed with squalene | | Descriptor: | (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene, Phosphatidylinositol transfer protein CSR1 | | Authors: | Chen, L, Tan, L, Im, Y.J. | | Deposit date: | 2022-02-12 | | Release date: | 2022-07-13 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
Acta Crystallogr D Struct Biol, 78, 2022
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7WVT
 | | Crystal structure of Saccharomyces cerevisiae Sfh2 complexed with phosphatidylinositol | | Descriptor: | (1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Phosphatidylinositol transfer protein CSR1 | | Authors: | Chen, L, Tan, L, Im, Y.J. | | Deposit date: | 2022-02-11 | | Release date: | 2022-07-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
Acta Crystallogr D Struct Biol, 78, 2022
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7D9R
 | | Structure of huamn soluble guanylate cyclase in the riociguat and NO-bound state | | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | | Authors: | Chen, L, Liu, R, Kang, Y. | | Deposit date: | 2020-10-14 | | Release date: | 2021-08-11 | | Last modified: | 2021-10-13 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
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7D9U
 | | Structure of human soluble guanylate cyclase in the cinciguat-bound activated state | | Descriptor: | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, ... | | Authors: | Chen, L, Liu, R, Kang, Y. | | Deposit date: | 2020-10-14 | | Release date: | 2021-08-11 | | Last modified: | 2021-10-13 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
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7D9S
 | | Structure of huamn soluble guanylate cyclase in the YC1 and NO-bound state | | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | | Authors: | Chen, L, Liu, R, Kang, Y. | | Deposit date: | 2020-10-14 | | Release date: | 2021-08-11 | | Last modified: | 2021-10-13 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
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7D9T
 | | Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state | | Descriptor: | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1 | | Authors: | Chen, L, Liu, R, Kang, Y. | | Deposit date: | 2020-10-14 | | Release date: | 2021-08-11 | | Last modified: | 2021-10-13 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators.
Nat Commun, 12, 2021
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5Z1F
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5YWD
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