7VLT
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![BU of 7vlt by Molmil](/molmil-images/mine/7vlt) | Structure of SUR2B in complex with Mg-ATP/ADP and levcromakalim | 分子名称: | (3S,4R)-2,2-dimethyl-3-oxidanyl-4-(2-oxidanylidenepyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Ding, D. | 登録日 | 2021-10-05 | 公開日 | 2022-05-18 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
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7VLR
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![BU of 7vlr by Molmil](/molmil-images/mine/7vlr) | Structure of SUR2B in complex with Mg-ATP/ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Chen, L, Ding, D. | 登録日 | 2021-10-05 | 公開日 | 2022-05-18 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
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7VLU
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![BU of 7vlu by Molmil](/molmil-images/mine/7vlu) | Structure of SUR2A in complex with Mg-ATP/ADP and P1075 | 分子名称: | 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Ding, D. | 登録日 | 2021-10-05 | 公開日 | 2022-05-18 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
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7VLS
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![BU of 7vls by Molmil](/molmil-images/mine/7vls) | Structure of SUR2B in complex with MgATP/ADP and P1075 | 分子名称: | 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Ding, D. | 登録日 | 2021-10-05 | 公開日 | 2022-05-18 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
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7WIC
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![BU of 7wic by Molmil](/molmil-images/mine/7wic) | Cryo-EM structure of the SS-14-bound human SSTR2-Gi1 complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Chen, L, Wang, W, Dong, Y, Shen, D, Guo, J, Qin, J, Zhang, H, Shen, Q, Zhang, Y, Mao, C. | 登録日 | 2022-01-03 | 公開日 | 2022-06-01 | 最終更新日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes. Cell Res., 32, 2022
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7E3X
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![BU of 7e3x by Molmil](/molmil-images/mine/7e3x) | Crystal structure of SDR family NAD(P)-dependent oxidoreductase from exiguobacterium | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase | 著者 | Chen, L, Tang, J, Yuan, S, Zhang, F, Chen, S. | 登録日 | 2021-02-09 | 公開日 | 2021-09-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Structure-guided evolution of a ketoreductase forefficient and stereoselective bioreduction of bulkyalpha-aminobeta-keto esters Catalysis Science And Technology, 2021
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7W4P
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![BU of 7w4p by Molmil](/molmil-images/mine/7w4p) | The structure of KATP H175K mutant in closed state | 分子名称: | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Wang, M. | 登録日 | 2021-11-28 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides. Nat Commun, 13, 2022
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7W4O
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![BU of 7w4o by Molmil](/molmil-images/mine/7w4o) | The structure of KATP H175K mutant in pre-open state | 分子名称: | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Wang, M. | 登録日 | 2021-11-28 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides. Nat Commun, 13, 2022
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7WDB
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![BU of 7wdb by Molmil](/molmil-images/mine/7wdb) | Human TRPC5 channel in complex with riluzole | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine, CALCIUM ION, ... | 著者 | Chen, L, Wei, M, Yang, Y. | 登録日 | 2021-12-21 | 公開日 | 2022-04-13 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structural identification of riluzole-binding site on human TRPC5. Cell Discov, 8, 2022
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2HJM
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8GVL
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![BU of 8gvl by Molmil](/molmil-images/mine/8gvl) | PTPN21 FERM | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Tyrosine-protein phosphatase non-receptor type 21 | 著者 | Chen, L, Zheng, Y.Y, Zhou, C. | 登録日 | 2022-09-15 | 公開日 | 2023-09-20 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
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8GWH
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8GVV
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![BU of 8gvv by Molmil](/molmil-images/mine/8gvv) | PTPN21 PTP domain C1108S mutant | 分子名称: | IODIDE ION, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 21 | 著者 | Chen, L, Zheng, Y.Y, Zhou, C. | 登録日 | 2022-09-15 | 公開日 | 2023-09-20 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
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8GXE
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![BU of 8gxe by Molmil](/molmil-images/mine/8gxe) | PTPN21 FERM PTP complex | 分子名称: | CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 21 | 著者 | Chen, L, Zheng, Y.Y, Zhou, C. | 登録日 | 2022-09-19 | 公開日 | 2023-09-27 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
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5Z1F
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7WWG
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![BU of 7wwg by Molmil](/molmil-images/mine/7wwg) | Crystal structure of Saccharomyces cerevisiae Sfh2 complexed with phosphatidylinositol in an open conformation | 分子名称: | (1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Phosphatidylinositol transfer protein CSR1 | 著者 | Chen, L, Tan, L, Im, Y.J. | 登録日 | 2022-02-12 | 公開日 | 2022-07-13 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily. Acta Crystallogr D Struct Biol, 78, 2022
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7WWD
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![BU of 7wwd by Molmil](/molmil-images/mine/7wwd) | Crystal structure of Saccharomyces cerevisiae Sfh2 complexed with squalene | 分子名称: | (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene, Phosphatidylinositol transfer protein CSR1 | 著者 | Chen, L, Tan, L, Im, Y.J. | 登録日 | 2022-02-12 | 公開日 | 2022-07-13 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily. Acta Crystallogr D Struct Biol, 78, 2022
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7WWE
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7WVT
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![BU of 7wvt by Molmil](/molmil-images/mine/7wvt) | Crystal structure of Saccharomyces cerevisiae Sfh2 complexed with phosphatidylinositol | 分子名称: | (1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Phosphatidylinositol transfer protein CSR1 | 著者 | Chen, L, Tan, L, Im, Y.J. | 登録日 | 2022-02-11 | 公開日 | 2022-07-13 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily. Acta Crystallogr D Struct Biol, 78, 2022
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5YWD
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5YW7
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7W7G
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7WIT
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![BU of 7wit by Molmil](/molmil-images/mine/7wit) | Structure of SUR1 in complex with mitiglinide | 分子名称: | (2S)-4-[(3aR,7aS)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-4-oxidanylidene-2-(phenylmethyl)butanoic acid, ADENOSINE-5'-TRIPHOSPHATE, ATP-sensitive inward rectifier potassium channel 11,ATP-binding cassette sub-family C member 8 isoform X1 | 著者 | Chen, L, Wang, M.M. | 登録日 | 2022-01-04 | 公開日 | 2022-11-16 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide Front Pharmacol, 13, 2022
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7WMV
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![BU of 7wmv by Molmil](/molmil-images/mine/7wmv) | Structure of human SGLT1-MAP17 complex bound with LX2761 | 分子名称: | N-[2-(dimethylamino)ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2S,3R,4R,5S,6R)-6-methylsulfanyl-3,4,5-tris(oxidanyl)oxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamide, PDZK1-interacting protein 1, Sodium/glucose cotransporter 1 | 著者 | Chen, L, Niu, Y, Cui, W. | 登録日 | 2022-01-17 | 公開日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural mechanism of SGLT1 inhibitors. Nat Commun, 13, 2022
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7E24
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