8GVV

PTPN21 PTP domain C1108S mutant

Summary for 8GVV

Entry DOI	10.2210/pdb8gvv/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 21, PHOSPHATE ION, IODIDE ION, ... (4 entities in total)
Functional Keywords	ptpn21, phosphotase domain, ptp, ptpd1, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35140.15
Authors	Chen, L.,Zheng, Y.Y.,Zhou, C. (deposition date: 2022-09-15, release date: 2023-09-20, Last modification date: 2024-04-17)
Primary citation	Chen, L.,Qian, Z.,Zheng, Y.,Zhang, J.,Sun, J.,Zhou, C.,Xiao, H. Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10:eadi7404-eadi7404, 2024 Cited by PubMed: 38416831 DOI: 10.1126/sciadv.adi7404 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation