1T3J
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![BU of 1t3j by Molmil](/molmil-images/mine/1t3j) | Mitofusin domain HR2 V686M/I708M mutant | 分子名称: | mitofusin 1 | 著者 | Koshiba, T, Detmer, S.A, Kaiser, J.T, Chen, H, McCaffery, J.M, Chan, D.C. | 登録日 | 2004-04-26 | 公開日 | 2004-08-17 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis of mitochondrial tethering by mitofusin complexes Science, 305, 2004
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4RVM
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![BU of 4rvm by Molmil](/molmil-images/mine/4rvm) | CHK1 kinase domain with diazacarbazole compound 19 | 分子名称: | 3-[4-(piperidin-1-ylmethyl)phenyl]-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, Serine/threonine-protein kinase Chk1 | 著者 | Gazzard, L, Blackwood, E, Burton, B, Chapman, K, Chen, H, Crackett, P, Drobnick, J, Ellwood, C, Epler, J, Flagella, M, Goodacre, S, Halladay, J, Hunt, H, Kintz, S, Lyssikatos, J, MacLeod, C, Ramiscal, S, Schmidt, S, Seward, E, Wiesmann, C, Williams, K, Wu, P, Yee, S, Yen, I, Malek, S. | 登録日 | 2014-11-26 | 公開日 | 2015-06-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1. J.Med.Chem., 58, 2015
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1VOL
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![BU of 1vol by Molmil](/molmil-images/mine/1vol) | TFIIB (HUMAN CORE DOMAIN)/TBP (A.THALIANA)/TATA ELEMENT TERNARY COMPLEX | 分子名称: | DNA (5'-D(*CP*AP*GP*CP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*GP*CP*TP*G)-3'), PROTEIN (TATA BINDING PROTEIN (TBP)), ... | 著者 | Nikolov, D.B, Chen, H, Halay, E.D, Usheva, A.U, Hisatake, K, Lee, D.K, Roeder, R.G, Burley, S.K. | 登録日 | 1996-04-29 | 公開日 | 1996-11-08 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of a TFIIB-TBP-TATA-element ternary complex. Nature, 377, 1995
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4R05
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![BU of 4r05 by Molmil](/molmil-images/mine/4r05) | Crystal structure of the refolded DENV3 methyltransferase | 分子名称: | Nonstructural protein NS5 | 著者 | Brecher, M.B, Li, Z, Zhang, J, Chen, H, Lin, Q, Liu, B, Li, H.M. | 登録日 | 2014-07-29 | 公開日 | 2014-11-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Refolding of a fully functional flavivirus methyltransferase revealed that S-adenosyl methionine but not S-adenosyl homocysteine is copurified with flavivirus methyltransferase. Protein Sci., 24, 2015
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3P2T
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![BU of 3p2t by Molmil](/molmil-images/mine/3p2t) | Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k) | 分子名称: | Leukocyte immunoglobulin-like receptor subfamily B member 4, SULFATE ION | 著者 | Chen, Y, Nam, G, Cheng, H, Zhang, J.H, Willcox, B.E, Gao, G.F. | 登録日 | 2010-10-04 | 公開日 | 2011-03-30 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.699 Å) | 主引用文献 | Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): a myeloid inhibitory receptor involved in immune tolerance J.Biol.Chem., 286, 2011
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3Q2C
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![BU of 3q2c by Molmil](/molmil-images/mine/3q2c) | Binding properties to HLA class I molecules and the structure of the leukocyte Ig-like receptor A3 (LILRA3/ILT6/LIR4/CD85e) | 分子名称: | Leukocyte immunoglobulin-like receptor subfamily A member 3 | 著者 | Ryu, M, Chen, Y, Qi, J.X, Liu, J, Shi, Y, Cheng, H, Gao, G.F. | 登録日 | 2010-12-20 | 公開日 | 2011-07-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence Plos One, 6, 2011
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2Z6T
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![BU of 2z6t by Molmil](/molmil-images/mine/2z6t) | Crystal structure of the ferric peroxo myoglobin | 分子名称: | Myoglobin, PEROXIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Unno, M, Kusama, S, Chen, H, Shaik, S, Ikeda-Saito, M. | 登録日 | 2007-08-08 | 公開日 | 2007-11-06 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structural Characterization of the Fleeting Ferric Peroxo Species in Myoglobin: Experiment and Theory J.Am.Chem.Soc., 129, 2007
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2CH5
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![BU of 2ch5 by Molmil](/molmil-images/mine/2ch5) | Crystal structure of human N-acetylglucosamine kinase in complex with N-acetylglucosamine | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | 著者 | Weihofen, W.A, Berger, M, Chen, H, Saenger, W, Hinderlich, S. | 登録日 | 2006-03-13 | 公開日 | 2006-09-18 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structures of Human N-Acetylglucosamine Kinase in Two Complexes with N-Acetylglucosamine and with Adp/Glucose: Insights Into Substrate Specificity and Regulation. J.Mol.Biol., 364, 2006
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2CH6
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![BU of 2ch6 by Molmil](/molmil-images/mine/2ch6) | Crystal structure of human N-acetylglucosamine kinase in complex with ADP and glucose | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, N-ACETYL-D-GLUCOSAMINE KINASE, alpha-D-glucopyranose | 著者 | Weihofen, W.A, Berger, M, Chen, H, Saenger, W, Hinderlich, S. | 登録日 | 2006-03-13 | 公開日 | 2006-09-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | Structures of Human N-Acetylglucosamine Kinase in Two Complexes with N-Acetylglucosamine and with Adp/Glucose: Insights Into Substrate Specificity and Regulation. J.Mol.Biol., 364, 2006
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2Z6S
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![BU of 2z6s by Molmil](/molmil-images/mine/2z6s) | Crystal structure of the oxy myoglobin free from X-ray-induced photoreduction | 分子名称: | Myoglobin, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Unno, M, Kusama, S, Chen, H, Shaik, S, Ikeda-Saito, M. | 登録日 | 2007-08-08 | 公開日 | 2007-11-06 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Structural Characterization of the Fleeting Ferric Peroxo Species in Myoglobin: Experiment and Theory J.Am.Chem.Soc., 129, 2007
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4FNW
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4FNZ
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![BU of 4fnz by Molmil](/molmil-images/mine/4fnz) | Crystal structure of human anaplastic lymphoma kinase in complex with piperidine-carboxamide inhibitor 2 | 分子名称: | (3S)-N-[3-(trifluoromethoxy)benzyl]-1-{2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}piperidine-3-carboxamide, ALK tyrosine kinase receptor | 著者 | Whittington, D.A, Epstein, L.F, Chen, H. | 登録日 | 2012-06-20 | 公開日 | 2012-08-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The R1275Q Neuroblastoma Mutant and Certain ATP-competitive Inhibitors Stabilize Alternative Activation Loop Conformations of Anaplastic Lymphoma Kinase. J.Biol.Chem., 287, 2012
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5AD3
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![BU of 5ad3 by Molmil](/molmil-images/mine/5ad3) | Bivalent binding to BET bromodomains | 分子名称: | 3-methoxy-N-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-N-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-amine, BROMODOMAIN-CONTAINING PROTEIN 4 | 著者 | Waring, M.J, Chen, H, Rabow, A.A, Walker, G, Bobby, R, Boiko, S, Bradbury, R.H, Callis, R, Dale, I, Daniels, D, Flavell, L, Holdgate, G, Jowitt, T.A, Kikhney, A, McAlister, M, Ogg, D, Patel, J, Petteruti, P, Robb, G.R, Robers, M, Stratton, N, Svergun, D.I, Wang, W, Whittaker, D. | 登録日 | 2015-08-19 | 公開日 | 2016-09-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Potent and Selective Bivalent Inhibitors of Bet Bromodomains Nat.Chem.Biol., 12, 2016
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5AD2
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![BU of 5ad2 by Molmil](/molmil-images/mine/5ad2) | Bivalent binding to BET bromodomains | 分子名称: | (3R)-4-(2-{4-[1-(3-chloro[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidinyl]phenoxy}ethyl)-1,3-dimethyl-2-piperazinone, BROMODOMAIN-CONTAINING PROTEIN 4 | 著者 | Waring, M.J, Chen, H, Rabow, A.A, Walker, G, Bobby, R, Boiko, S, Bradbury, R.H, Callis, R, Dale, I, Daniels, D, Flavell, L, Holdgate, G, Jowitt, T.A, Kikhney, A, McAlister, M, Ogg, D, Patel, J, Petteruti, P, Robb, G.R, Robers, M, Stratton, N, Svergun, D.I, Wang, W, Whittaker, D. | 登録日 | 2015-08-19 | 公開日 | 2016-09-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Potent and Selective Bivalent Inhibitors of Bet Bromodomains Nat.Chem.Biol., 12, 2016
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5CFB
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![BU of 5cfb by Molmil](/molmil-images/mine/5cfb) | Crystal Structure of Human Glycine Receptor alpha-3 Bound to Strychnine | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alpha-3,Glycine receptor subunit alpha-3, ... | 著者 | Shaffer, P.L, Huang, X, Chen, H. | 登録日 | 2015-07-08 | 公開日 | 2015-09-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.04 Å) | 主引用文献 | Crystal structure of human glycine receptor-alpha 3 bound to antagonist strychnine. Nature, 526, 2015
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4RZF
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![BU of 4rzf by Molmil](/molmil-images/mine/4rzf) | Crystal Structure Analysis of the NUR77 Ligand Binding Domain, S441W mutant | 分子名称: | GLYCEROL, Nuclear receptor subfamily 4 group A member 1 | 著者 | Li, F, Tian, X, Li, A, Li, L, Liu, Y, Chen, H, Wu, Q, Lin, T. | 登録日 | 2014-12-21 | 公開日 | 2015-03-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol., 11, 2015
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4RZG
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![BU of 4rzg by Molmil](/molmil-images/mine/4rzg) | Crystal Structure Analysis of the DNPA-bounded NUR77 Ligand binding Domain | 分子名称: | GLYCEROL, Nuclear receptor subfamily 4 group A member 1, pentyl (3,5-dihydroxy-2-nonanoylphenyl)acetate | 著者 | Li, F, Tian, X, Li, A, Li, L, Liu, Y, Chen, H, Wu, Q, Lin, T. | 登録日 | 2014-12-21 | 公開日 | 2015-03-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat.Chem.Biol., 11, 2015
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3UBU
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![BU of 3ubu by Molmil](/molmil-images/mine/3ubu) | Crystal structure of agkisacucetin, a GpIb-binding snaclec (snake C-type lectin) that inhibits platelet | 分子名称: | Agglucetin subunit alpha-1, Agglucetin subunit beta-2, GLYCEROL, ... | 著者 | Gao, Y, Ge, H, Chen, H, Li, H, Liu, Y, Niu, L, Teng, M. | 登録日 | 2011-10-25 | 公開日 | 2012-04-11 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Crystal structure of agkisacucetin, a Gpib-binding snake C-type lectin that inhibits platelet adhesion and aggregation. Proteins, 2012
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5TIN
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![BU of 5tin by Molmil](/molmil-images/mine/5tin) | Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607 | 分子名称: | (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one, CHLORIDE ION, GLYCINE, ... | 著者 | Shaffer, P.L, Huang, X, Chen, H. | 登録日 | 2016-10-03 | 公開日 | 2017-01-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Crystal Structures of Human GlyRa3 Bound to a Novel Class of Potentiators with Efficacy in a Mouse Model of Neuropathic Pain To Be Published
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5TIO
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![BU of 5tio by Molmil](/molmil-images/mine/5tio) | Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607 | 分子名称: | (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ... | 著者 | Shaffer, P.L, Huang, X, Chen, H. | 登録日 | 2016-10-03 | 公開日 | 2017-01-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Crystal Structures of Human GlyRa3 Bound to a Novel Class of Potentiators with Efficacy in a Mouse Model of Neuropathic Pain To Be Published
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4J98
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5UHN
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5UI0
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5UGX
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5UGL
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![BU of 5ugl by Molmil](/molmil-images/mine/5ugl) | |