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5AD2

Bivalent binding to BET bromodomains

Summary for 5AD2
Entry DOI10.2210/pdb5ad2/pdb
Related5AD3
DescriptorBROMODOMAIN-CONTAINING PROTEIN 4, (3R)-4-(2-{4-[1-(3-chloro[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidinyl]phenoxy}ethyl)-1,3-dimethyl-2-piperazinone (3 entities in total)
Functional Keywordstranscription
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus: O60885
Total number of polymer chains2
Total formula weight30682.75
Authors
Primary citationWaring, M.J.,Chen, H.,Rabow, A.A.,Walker, G.,Bobby, R.,Boiko, S.,Bradbury, R.H.,Callis, R.,Clark, E.,Dale, I.,Daniels, D.L.,Dulak, A.,Flavell, L.,Holdgate, G.,Jowitt, T.A.,Kikhney, A.,Mcalister, M.,Ogg, D.,Patel, J.,Petteruti, P.,Robb, G.R.,Robers, M.B.,Saif, S.,Stratton, N.,Svergun, D.I.,Wang, W.,Whittaker, D.,Wilson, D.M.,Yao, Y.
Potent and Selective Bivalent Inhibitors of Bet Bromodomains
Nat.Chem.Biol., 12:1097-, 2016
Cited by
PubMed: 27775716
DOI: 10.1038/NCHEMBIO.2210
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.01 Å)
Structure validation

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