5AD2
Bivalent binding to BET bromodomains
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | BROMODOMAIN-CONTAINING PROTEIN 4 | polymer | 127 | 15099.4 | 2 | UniProt (O60885) Pfam (PF00439) | HOMO SAPIENS (HUMAN) | PROTEIN HUNK1, BRD4 |
| 2 | C (A) | (3R)-4-(2-{4-[1-(3-chloro[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidinyl]phenoxy}ethyl)-1,3-dimethyl-2-piperazinone | non-polymer | 484.0 | 1 | Chemie (ETU) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 257 | Chemie (HOH) |
Sequence modifications
A, B: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30198.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 484.0 | |
| All* | Total formula weight | 30682.8 |
