4RVM
CHK1 kinase domain with diazacarbazole compound 19
Summary for 4RVM
Entry DOI | 10.2210/pdb4rvm/pdb |
Descriptor | Serine/threonine-protein kinase Chk1, 3-[4-(piperidin-1-ylmethyl)phenyl]-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile (3 entities in total) |
Functional Keywords | protein kinase, phosphotransfer catalyst, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 34572.65 |
Authors | Gazzard, L.,Blackwood, E.,Burton, B.,Chapman, K.,Chen, H.,Crackett, P.,Drobnick, J.,Ellwood, C.,Epler, J.,Flagella, M.,Goodacre, S.,Halladay, J.,Hunt, H.,Kintz, S.,Lyssikatos, J.,MacLeod, C.,Ramiscal, S.,Schmidt, S.,Seward, E.,Wiesmann, C.,Williams, K.,Wu, P.,Yee, S.,Yen, I.,Malek, S. (deposition date: 2014-11-26, release date: 2015-06-03, Last modification date: 2023-09-20) |
Primary citation | Gazzard, L.,Williams, K.,Chen, H.,Axford, L.,Blackwood, E.,Burton, B.,Chapman, K.,Crackett, P.,Drobnick, J.,Ellwood, C.,Epler, J.,Flagella, M.,Gancia, E.,Gill, M.,Goodacre, S.,Halladay, J.,Hewitt, J.,Hunt, H.,Kintz, S.,Lyssikatos, J.,Macleod, C.,Major, S.,Medard, G.,Narukulla, R.,Ramiscal, J.,Schmidt, S.,Seward, E.,Wiesmann, C.,Wu, P.,Yee, S.,Yen, I.,Malek, S. Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1. J.Med.Chem., 58:5053-5074, 2015 Cited by PubMed: 25988399DOI: 10.1021/acs.jmedchem.5b00464 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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