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5TIO

Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607

Summary for 5TIO
Entry DOI10.2210/pdb5tio/pdb
Related5TIN
DescriptorGlycine receptor subunit alpha-3, (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one, GLYCINE, ... (5 entities in total)
Functional Keywordsligand-gated ion channel neurotransmitter receptor membrane protein cys-loop receptor, transport protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains5
Total formula weight212217.78
Authors
Shaffer, P.L.,Huang, X.,Chen, H. (deposition date: 2016-10-03, release date: 2017-01-18, Last modification date: 2023-10-04)
Primary citationHuang, X.,Shaffer, P.L.,Ayube, S.,Bregman, H.,Chen, H.,Lehto, S.G.,Luther, J.A.,Matson, D.J.,McDonough, S.I.,Michelsen, K.,Plant, M.M.,Schneider, S.,Simard, J.R.,Teffera, Y.,Yi, S.,Zhang, M.,DiMauro, E.F.,Gingras, J.
Crystal Structures of Human GlyRa3 Bound to a Novel Class of Potentiators with Efficacy in a Mouse Model of Neuropathic Pain
To Be Published,
Experimental method
X-RAY DIFFRACTION (3.25 Å)
Structure validation

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