5TIO
Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (C, A, B, D, E) | Glycine receptor subunit alpha-3 | polymer | 362 | 41857.4 | 5 | UniProt (O75311) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (Human) | |
| 2 | F, J, M, P, S (C, A, B, D, E) | (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one | non-polymer | 401.4 | 5 | Chemie (7C6) | |||
| 3 | G, K, N, R, T (C, A, B, D, E) | GLYCINE | non-polymer | 75.1 | 5 | Chemie (GLY) | |||
| 4 | H, L, O, Q, U (C, A, B, D, E) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 5 | I (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
C, A, B, D, E: 1 - 309 (UniProt: O75311)
C, A, B, D, E: 313 - 354 (UniProt: O75311)
C, A, B, D, E: 313 - 354 (UniProt: O75311)
| PDB | External Database | Details |
|---|---|---|
| Ala 310 | - | linker |
| Gly 311 | - | linker |
| Thr 312 | - | linker |
| Trp 355 | - | expression tag |
| Ser 356 | - | expression tag |
| His 357 | - | expression tag |
| Pro 358 | - | expression tag |
| Gln 359 | - | expression tag |
| Phe 360 | - | expression tag |
| Glu 361 | - | expression tag |
| Lys 362 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 209287.0 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2930.8 | |
| All* | Total formula weight | 212217.8 |
