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PDB: 235 件
4IQC
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P3121 crystal form of FKBP12.6
分子名称: Peptidyl-prolyl cis-trans isomerase FKBP1B
著者Chen, H, Mustafi, S.M, Li, H.M, LeMaster, D.M, Hernandez, G.
登録日2013-01-11
公開日2014-01-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.903 Å)
主引用文献Crystal structure and conformational flexibility of the unligated FK506-binding protein FKBP12.6.
Acta Crystallogr.,Sect.D, 70, 2014
193D
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BU of 193d by Molmil
SOLUTION STRUCTURE OF A QUINOMYCIN BISINTERCALATOR-DNA COMPLEX
分子名称: 3-HYDROXYQUINALDIC ACID, DNA (5'-D(*AP*CP*AP*CP*GP*TP*GP*T)-3'), QUINOMYCIN
著者Chen, H, Patel, D.J.
登録日1994-09-30
公開日1995-02-27
最終更新日2017-11-01
実験手法SOLUTION NMR
主引用文献Solution Structure of a Quinomycin Bisintercalator-DNA Complex.
J.Mol.Biol., 246, 1995
3MEX
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BU of 3mex by Molmil
Crystal structure of MexR in oxidized state
分子名称: Multidrug resistance operon repressor
著者Chen, H, Yi, C, Zhang, J, Zhang, W, Yang, C.-G, He, C.
登録日2010-04-01
公開日2010-07-28
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR
Embo Rep., 11, 2010
4J99
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Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659T Mutation.
分子名称: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
著者Chen, H, Mohammadi, M.
登録日2013-02-15
公開日2013-08-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.8474 Å)
主引用文献Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4, 2013
4J96
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Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659M Mutation Identified in Cervical Cancer.
分子名称: CITRATE ANION, Fibroblast growth factor receptor 2, MAGNESIUM ION, ...
著者Chen, H, Mohammadi, M.
登録日2013-02-15
公開日2013-08-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2972 Å)
主引用文献Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4, 2013
4J95
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Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome in Space Group C2.
分子名称: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
著者Chen, H, Mohammadi, M.
登録日2013-02-15
公開日2013-08-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3767 Å)
主引用文献Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4, 2013
4J97
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Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659E Mutation Identified in Endometrial Cancer.
分子名称: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
著者Chen, H, Mohammadi, M.
登録日2013-02-15
公開日2013-08-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5482 Å)
主引用文献Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4, 2013
2PWL
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BU of 2pwl by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549H Mutation Responsible for Crouzon Syndrome.
分子名称: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
著者Chen, H, Mohammadi, M.
登録日2007-05-11
公開日2007-09-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PVF
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Crystal Structure of Tyrosine Phosphorylated Activated FGF Receptor 2 (FGFR2) Kinase Domain in Complex with ATP Analog and Substrate Peptide
分子名称: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
著者Chen, H, Mohammadi, M.
登録日2007-05-09
公開日2007-09-25
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
2PZ5
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Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome
分子名称: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
著者Chen, H, Mohammadi, M.
登録日2007-05-17
公開日2007-09-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Mol.Cell, 27, 2007
8GYB
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Crystal structure of Alongshan virus methyltransferase bound to S-adenosyl-L-homocysteine
分子名称: Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Chen, H, Lin, S, Lu, G.W.
登録日2022-09-22
公開日2023-09-27
最終更新日2024-04-10
実験手法X-RAY DIFFRACTION (2.101 Å)
主引用文献Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.
Plos Pathog., 19, 2023
8GYA
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Crystal structure of Alongshan virus methyltransferase bound to Sinefungin
分子名称: Methyltransferase, SINEFUNGIN
著者Chen, H, Lin, S, Lu, G.W.
登録日2022-09-21
公開日2023-09-27
最終更新日2024-04-10
実験手法X-RAY DIFFRACTION (2.005 Å)
主引用文献Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.
Plos Pathog., 19, 2023
8GY4
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Crystal structure of Alongshan virus methyltransferase
分子名称: Methyltransferase
著者Chen, H, Lin, S, Lu, G.W.
登録日2022-09-21
公開日2023-09-27
最終更新日2024-04-10
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.
Plos Pathog., 19, 2023
8GY9
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BU of 8gy9 by Molmil
Crystal structure of Alongshan virus methyltransferase bound to S-adenosyl-L-methionine
分子名称: Methyltransferase, S-ADENOSYLMETHIONINE
著者Chen, H, Lin, S, Lu, G.W.
登録日2022-09-21
公開日2023-09-27
最終更新日2024-04-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and functional basis of low-affinity SAM/SAH-binding in the conserved MTase of the multi-segmented Alongshan virus distantly related to canonical unsegmented flaviviruses.
Plos Pathog., 19, 2023
3CLY
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BU of 3cly by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domains Trapped in Trans-Phosphorylation Reaction
分子名称: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
著者Chen, H, Mohammadi, M.
登録日2008-03-20
公開日2009-02-03
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A crystallographic snapshot of tyrosine trans-phosphorylation in action
Proc.Natl.Acad.Sci.USA, 105, 2008
3E17
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BU of 3e17 by Molmil
Crystal structure of the second PDZ domain from human Zona Occludens-2
分子名称: Tight junction protein ZO-2
著者Chen, H, Tong, S.L, Teng, M.K, Niu, L.W.
登録日2008-08-01
公開日2009-07-21
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure of the second PDZ domain from human zonula occludens 2
Acta Crystallogr.,Sect.F, 65, 2009
5BYZ
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BU of 5byz by Molmil
ERK5 in complex with small molecule
分子名称: 4-({5-fluoro-4-[2-methyl-1-(propan-2-yl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)-N-[2-(piperidin-1-yl)ethyl]benzamide, GLYCEROL, Mitogen-activated protein kinase 7
著者Chen, H, Tucker, J, Wang, X, Gavine, P.R, Philips, C, Augustin, M.A, Schreiner, P, Steinbacher, S, Preston, M, Ogg, D.
登録日2015-06-11
公開日2016-05-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Acta Crystallogr D Struct Biol, 72, 2016
5BYY
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ERK5 IN COMPLEX WITH SMALL MOLECULE
分子名称: 2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Mitogen-activated protein kinase 7
著者Chen, H, Tucker, J, Wang, X, Gavine, P.R, Philips, C, Augustin, M.A, Schreiner, P, Steinbacher, S, Preston, M, Ogg, D.
登録日2015-06-11
公開日2016-05-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Acta Crystallogr D Struct Biol, 72, 2016
8G92
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Structure of inhibitor 16d-bound SPNS2
分子名称: 3-[3-(4-decylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-amine, Sphingosine-1-phosphate transporter SPNS2
著者Chen, H, Li, X.
登録日2023-02-21
公開日2023-05-24
最終更新日2023-12-13
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate.
Cell, 186, 2023
8G94
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Structure of CD69-bound S1PR1 coupled to heterotrimeric Gi
分子名称: Early activation antigen CD69, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Chen, H, Li, X.
登録日2023-02-21
公開日2023-04-19
最終更新日2023-04-26
実験手法ELECTRON MICROSCOPY (3.15 Å)
主引用文献Transmembrane protein CD69 acts as an S1PR1 agonist.
Elife, 12, 2023
5Y5A
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Crystal structure of Est1 and Cdc13
分子名称: KLLA0F20702p, KLLA0F20922p
著者Chen, H, Xue, J, Wu, J, Lei, M.
登録日2017-08-08
公開日2017-12-20
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.206 Å)
主引用文献Structural Insights into Yeast Telomerase Recruitment to Telomeres
Cell, 172, 2018
5Y58
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Crystal structure of Ku70/80 and TLC1
分子名称: ATP-dependent DNA helicase II subunit 1, ATP-dependent DNA helicase II subunit 2, TLC1
著者Chen, H, Xue, J, Wu, J, Lei, M.
登録日2017-08-08
公開日2017-12-20
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Insights into Yeast Telomerase Recruitment to Telomeres
Cell, 172, 2018
6AGK
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The structure of CH-II-77-tubulin complex
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Chen, H, Arnst, K, Wang, Y, Miller, D, Li, W.
登録日2018-08-13
公開日2019-08-21
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.
J.Med.Chem., 63, 2020
5Y59
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Crystal structure of Ku80 and Sir4
分子名称: ATP-dependent DNA helicase II subunit 2, SULFATE ION, Sir4p
著者Chen, H, Xue, J, Wu, J, Lei, M.
登録日2017-08-08
公開日2017-12-20
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.402 Å)
主引用文献Structural Insights into Yeast Telomerase Recruitment to Telomeres
Cell, 172, 2018
7D8H
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CRTC1 pSer64 peptide in complex with 14-3-3 zeta
分子名称: 14-3-3 protein zeta/delta, CRTC1 pSer64 peptide
著者Chen, H, Zhang, H, Xiang, S.
登録日2020-10-08
公開日2021-02-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Structural Insights into the Interaction Between CRTCs and 14-3-3.
J.Mol.Biol., 433, 2021

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