1T32
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![BU of 1t32 by Molmil](/molmil-images/mine/1t32) | A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation | 分子名称: | 2-[3-({METHYL[1-(2-NAPHTHOYL)PIPERIDIN-4-YL]AMINO}CARBONYL)-2-NAPHTHYL]-1-(1-NAPHTHYL)-2-OXOETHYLPHOSPHONIC ACID, Cathepsin G, SULFATE ION | 著者 | de Garavilla, L, Greco, M.N, Giardino, E.C, Wells, G.I, Haertlein, B.J, Kauffman, J.A, Corcoran, T.W, Derian, C.K, Eckardt, A.J, Abraham, W.M, Sukumar, N, Chen, Z, Pineda, A.O, Mathews, F.S, Di Cera, E, Andrade-Gordon, P, Damiano, B.P, Maryanoff, B.E. | 登録日 | 2004-04-23 | 公開日 | 2005-03-01 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo. J.Biol.Chem., 280, 2005
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1L9E
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![BU of 1l9e by Molmil](/molmil-images/mine/1l9e) | Role of Histidine 269 in Catalysis by Monomeric Sarcosine Oxidase | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, IMIDAZOLE, ... | 著者 | Zhao, G, Song, H, Chen, Z.-w, Mathews, F.S, Jorns, M.S. | 登録日 | 2002-03-22 | 公開日 | 2002-08-30 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Monomeric sarcosine oxidase: role of histidine 269 in catalysis. Biochemistry, 41, 2002
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5Z3V
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![BU of 5z3v by Molmil](/molmil-images/mine/5z3v) | Structure of Snf2-nucleosome complex at shl-2 in ADP BeFx state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (167-MER), ... | 著者 | Li, M, Xia, X, Liu, X, Li, X, Chen, Z. | 登録日 | 2018-01-08 | 公開日 | 2019-05-22 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.22 Å) | 主引用文献 | Mechanism of DNA translocation underlying chromatin remodelling by Snf2. Nature, 567, 2019
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5Z3O
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![BU of 5z3o by Molmil](/molmil-images/mine/5z3o) | Structure of Snf2-nucleosome complex in ADP state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (167-MER), Histone H2A, ... | 著者 | Li, M, Xia, X, Liu, X, Li, X, Chen, Z. | 登録日 | 2018-01-08 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.62 Å) | 主引用文献 | Mechanism of DNA translocation underlying chromatin remodelling by Snf2. Nature, 567, 2019
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6AOI
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![BU of 6aoi by Molmil](/molmil-images/mine/6aoi) | Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-phenylpiperazin-1-yl)-6-propylpyrimidine-2,4-diamine (TRC-2528) | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(4-phenylpiperazin-1-yl)-6-propylpyrimidine-2,4-diamine, ... | 著者 | Thomas, S.B, Li, Y, Chen, Z, Lu, H. | 登録日 | 2017-08-16 | 公開日 | 2018-08-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | 主引用文献 | Identification of selective, brain penetrant Toxoplasma gondii dihydrofolate reductase inhibitors for the treatment of toxoplasmosis To Be Published
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4DT7
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![BU of 4dt7 by Molmil](/molmil-images/mine/4dt7) | Crystal structure of thrombin bound to the activation domain QEDQVDPRLIDGKMTRRGDS of protein C | 分子名称: | ACETATE ION, DI(HYDROXYETHYL)ETHER, SODIUM ION, ... | 著者 | Pozzi, N, Barranco-Medina, S, Chen, Z, Di Cera, E. | 登録日 | 2012-02-20 | 公開日 | 2012-05-09 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Exposure of R169 controls protein C activation and autoactivation. Blood, 120, 2012
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3QQ4
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![BU of 3qq4 by Molmil](/molmil-images/mine/3qq4) | Crystal structure of swine major histocompatibility complex class I SLA-1 0401 and identification of 2009 pandemic swine-origin influenza A H1N1 virus cytotoxic T lymphocyte epitope peptides | 分子名称: | Beta-2-microglobulin, MHC class I antigen, VP35 | 著者 | Zhang, N, Qi, J, Gao, F, Pan, X, Chen, R, Li, Q, Chen, Z, Li, X, Xia, C, Gao, G.F. | 登録日 | 2011-02-15 | 公開日 | 2011-12-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.097 Å) | 主引用文献 | Crystal structure of swine major histocompatibility complex class I SLA-1 0401 and identification of 2009 pandemic swine-origin influenza A H1N1 virus cytotoxic T lymphocyte epitope peptides. J.Virol., 85, 2011
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4QQN
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![BU of 4qqn by Molmil](/molmil-images/mine/4qqn) | Protein arginine methyltransferase 3 in complex with compound MTV044246 | 分子名称: | 1-{2-[1-(aminomethyl)cyclohexyl]ethyl}-3-isoquinolin-6-ylurea, CHLORIDE ION, GLYCEROL, ... | 著者 | Dong, A, Dobrovetsky, E, Tempel, W, He, H, Zhao, K, Smil, D, Landon, M, Luo, X, Chen, Z, Dai, M, Yu, Z, Lin, Y, Zhang, H, Zhao, K, Schapira, M, Brown, P.J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Vedadi, M, Structural Genomics Consortium (SGC) | 登録日 | 2014-06-27 | 公開日 | 2014-09-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3). J. Med. Chem., 61, 2018
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1NWO
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![BU of 1nwo by Molmil](/molmil-images/mine/1nwo) | |
1NWP
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![BU of 1nwp by Molmil](/molmil-images/mine/1nwp) | |
3J6C
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![BU of 3j6c by Molmil](/molmil-images/mine/3j6c) | Cryo-EM structure of MAVS CARD filament | 分子名称: | Mitochondrial antiviral-signaling protein | 著者 | Xu, H, He, X, Zheng, H, Huang, L.J, Hou, F, Yu, Z, de la Cruz, M.J, Borkowski, B, Zhang, X, Chen, Z.J, Jiang, Q.-X. | 登録日 | 2014-02-04 | 公開日 | 2014-03-05 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (9.6 Å) | 主引用文献 | Structural basis for the prion-like MAVS filaments in antiviral innate immunity. Elife, 3, 2014
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2OD3
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![BU of 2od3 by Molmil](/molmil-images/mine/2od3) | Human thrombin chimera with human residues 184a, 186, 186a, 186b, 186c and 222 replaced by murine thrombin equivalents. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Thrombin heavy chain, ... | 著者 | Marino, F, Chen, Z, Ergenekan, C.E, Bush, L.A, Mathews, F.S, Di Cera, E. | 登録日 | 2006-12-21 | 公開日 | 2007-04-10 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural basis of na+ activation mimicry in murine thrombin. J.Biol.Chem., 282, 2007
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4DSB
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![BU of 4dsb by Molmil](/molmil-images/mine/4dsb) | Complex Structure of Abscisic Acid Receptor PYL3 with (+)-ABA in Spacegroup of I 212121 at 2.70A | 分子名称: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, Abscisic acid receptor PYL3 | 著者 | Zhang, X, Zhang, Q, Chen, Z. | 登録日 | 2012-02-18 | 公開日 | 2012-06-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Complex Structures of the Abscisic Acid Receptor PYL3/RCAR13 Reveal a Unique Regulatory Mechanism Structure, 20, 2012
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5Z3U
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![BU of 5z3u by Molmil](/molmil-images/mine/5z3u) | Structure of Snf2-nucleosome complex at shl2 in ADP BeFx state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (167-MER), ... | 著者 | Li, M, Xia, X, Liu, X, Li, X, Chen, Z. | 登録日 | 2018-01-08 | 公開日 | 2019-05-22 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.31 Å) | 主引用文献 | Mechanism of DNA translocation underlying chromatin remodelling by Snf2. Nature, 567, 2019
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1NS3
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![BU of 1ns3 by Molmil](/molmil-images/mine/1ns3) | STRUCTURE OF HCV PROTEASE (BK STRAIN) | 分子名称: | NS3 PROTEASE, NS4A PEPTIDE, ZINC ION | 著者 | Yan, Y, Munshi, S, Chen, Z. | 登録日 | 1997-04-05 | 公開日 | 1998-04-08 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form. Protein Sci., 7, 1998
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3K3N
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![BU of 3k3n by Molmil](/molmil-images/mine/3k3n) | Crystal structure of the catalytic core domain of human PHF8 | 分子名称: | FE (II) ION, PHD finger protein 8 | 著者 | Yu, L, Wang, Y, Huang, S, Wang, J, Deng, Z, Wu, W, Gong, W, Chen, Z. | 登録日 | 2009-10-03 | 公開日 | 2010-01-19 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural insights into a novel histone demethylase PHF8 Cell Res., 20, 2010
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4DSC
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![BU of 4dsc by Molmil](/molmil-images/mine/4dsc) | Complex structure of abscisic acid receptor PYL3 with (+)-ABA in spacegroup of H32 at 1.95A | 分子名称: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, Abscisic acid receptor PYL3, MAGNESIUM ION | 著者 | Zhang, X, Chen, Z. | 登録日 | 2012-02-18 | 公開日 | 2012-06-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Complex Structures of the Abscisic Acid Receptor PYL3/RCAR13 Reveal a Unique Regulatory Mechanism Structure, 20, 2012
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3JZ2
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![BU of 3jz2 by Molmil](/molmil-images/mine/3jz2) | Crystal structure of human thrombin mutant N143P in E* form | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Thrombin heavy chain, ... | 著者 | Niu, W, Chen, Z, Bush-Pelc, L.A, Bah, A, Gandhi, P.S, Di Cera, E. | 登録日 | 2009-09-22 | 公開日 | 2009-10-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Mutant N143P reveals how Na+ activates thrombin J.Biol.Chem., 284, 2009
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4H6T
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![BU of 4h6t by Molmil](/molmil-images/mine/4h6t) | Crystal structure of prethrombin-2 mutant E14eA/D14lA/E18A/S195A | 分子名称: | PHOSPHATE ION, Prothrombin | 著者 | Pozzi, N, Chen, Z, Zapata, F, Pelc, L.A, Di Cera, E. | 登録日 | 2012-09-19 | 公開日 | 2013-03-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Autoactivation of thrombin precursors. J.Biol.Chem., 288, 2013
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4H6S
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![BU of 4h6s by Molmil](/molmil-images/mine/4h6s) | Crystal structure of thrombin mutant E14eA/D14lA/E18A/S195A | 分子名称: | Prothrombin, SODIUM ION | 著者 | Pozzi, N, Chen, Z, Zapata, F, Pelc, L.A, Di Cera, E. | 登録日 | 2012-09-19 | 公開日 | 2013-03-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Autoactivation of thrombin precursors. J.Biol.Chem., 288, 2013
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3QDZ
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![BU of 3qdz by Molmil](/molmil-images/mine/3qdz) | Crystal structure of the human thrombin mutant D102N in complex with the extracellular fragment of human PAR4. | 分子名称: | Proteinase-activated receptor 4, Thrombin heavy chain, Thrombin light chain | 著者 | Gandhi, P, Chen, Z, Appelbaum, E, Zapata, F, Di Cera, E. | 登録日 | 2011-01-19 | 公開日 | 2011-06-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis of thrombin-protease-receptor interactions IUBMB LIFE, 63, 2011
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3QQ3
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![BU of 3qq3 by Molmil](/molmil-images/mine/3qq3) | Crystal structure of swine major histocompatibility complex class I SLA-1 0401 and identification of 2009 pandemic swine-origin influenza A H1N1 virus cytotoxic T lymphocyte epitope peptides | 分子名称: | 9-mer peptide from Neuraminidase, Beta-2-microglobulin, MHC class I antigen | 著者 | Zhang, N, Qi, J, Gao, F, Pan, X, Chen, R, Li, Q, Chen, Z, Li, X, Xia, C, Gao, G.F. | 登録日 | 2011-02-15 | 公開日 | 2011-12-28 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Crystal structure of swine major histocompatibility complex class I SLA-1 0401 and identification of 2009 pandemic swine-origin influenza A H1N1 virus cytotoxic T lymphocyte epitope peptides. J.Virol., 85, 2011
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5Z3L
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![BU of 5z3l by Molmil](/molmil-images/mine/5z3l) | Structure of Snf2-nucleosome complex in apo state | 分子名称: | DNA (167-MER), Histone H2A, Histone H2B 1.1, ... | 著者 | Li, M, Xia, X, Liu, X, Li, X, Chen, Z. | 登録日 | 2018-01-08 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.31 Å) | 主引用文献 | Mechanism of DNA translocation underlying chromatin remodelling by Snf2. Nature, 567, 2019
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4JDL
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1MG2
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![BU of 1mg2 by Molmil](/molmil-images/mine/1mg2) | MUTATION OF ALPHA PHE55 OF METHYLAMINE DEHYDROGENASE ALTERS THE REORGANIZATION ENERGY AND ELECTRONIC COUPLING FOR ITS ELECTRON TRANSFER REACTION WITH AMICYANIN | 分子名称: | Amicyanin, COPPER (II) ION, CYTOCHROME C-L, ... | 著者 | Sun, D, Chen, Z.W, Mathews, F.S, Davidson, V.L. | 登録日 | 2002-08-14 | 公開日 | 2002-12-11 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | MUTATION OF AlPHA PHE55 OF METHYLAMINE DEHYDROGENASE ALTERS THE REORGANIZATION ENERGY AND ELECTRONIC COUPLING FOR ITS ELECTRON TRANSFER REACTION WITH AMICYANIN Biochemistry, 41, 2002
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