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4QQN

Protein arginine methyltransferase 3 in complex with compound MTV044246

Summary for 4QQN
Entry DOI10.2210/pdb4qqn/pdb
DescriptorPRMT3 protein, 1-{2-[1-(aminomethyl)cyclohexyl]ethyl}-3-isoquinolin-6-ylurea, GLYCEROL, ... (6 entities in total)
Functional Keywordsprmt3, structural genomics, structural genomics consortium, sgc, transferase, epigenetics
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight38735.90
Authors
Primary citationKaniskan, H.U.,Eram, M.S.,Zhao, K.,Szewczyk, M.M.,Yang, X.,Schmidt, K.,Luo, X.,Xiao, S.,Dai, M.,He, F.,Zang, I.,Lin, Y.,Li, F.,Dobrovetsky, E.,Smil, D.,Min, S.J.,Lin-Jones, J.,Schapira, M.,Atadja, P.,Li, E.,Barsyte-Lovejoy, D.,Arrowsmith, C.H.,Brown, P.J.,Liu, F.,Yu, Z.,Vedadi, M.,Jin, J.
Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3).
J. Med. Chem., 61:1204-1217, 2018
Cited by
PubMed: 29244490
DOI: 10.1021/acs.jmedchem.7b01674
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.08 Å)
Structure validation

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