3QDZ

Crystal structure of the human thrombin mutant D102N in complex with the extracellular fragment of human PAR4.

Summary for 3QDZ

• Entry DOI: 10.2210/pdb3qdz/pdb
• Related: 1SHH
• Descriptor: Thrombin light chain, Thrombin heavy chain, Proteinase-activated receptor 4 (3 entities in total)
• Functional Keywords: serine protease, protein function, protease-activated receptors, hydrolase-hydrolase receptor complex, hydrolase/hydrolase receptor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734; Cell membrane; Multi-pass membrane protein: Q96RI0
• Total number of polymer chains: 6
• Total formula weight: 68756.87

Authors

Gandhi, P.,Chen, Z.,Appelbaum, E.,Zapata, F.,Di Cera, E. (deposition date: 2011-01-19, release date: 2011-06-29, Last modification date: 2024-10-16)

• Primary citation: Gandhi, P.S.,Chen, Z.,Appelbaum, E.,Zapata, F.,Di Cera, E.; Structural basis of thrombin-protease-receptor interactions; IUBMB LIFE, 63:375-382, 2011

Experimental method

X-RAY DIFFRACTION (2.8 Å)