3QDZ

Crystal structure of the human thrombin mutant D102N in complex with the extracellular fragment of human PAR4.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Thrombin light chain	polymer	31	3647.1	2	UniProt (P00734) Pfam (PF09396) In PDB	Homo sapiens (human)	Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain
2	B, D	Thrombin heavy chain	polymer	259	29779.2	2	UniProt (P00734) Pfam (PF00089) In PDB	Homo sapiens (human)	Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain
3	E, F	Proteinase-activated receptor 4	polymer	9	952.1	2	UniProt (Q96RI0) In PDB	Homo sapiens (human)	PAR-4, Coagulation factor II receptor-like 3, Thrombin receptor-like 3

Sequence modifications

B, D: 16 - 247 (UniProt: P00734)

PDB	External Database	Details
Asn 102	Asp 462	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	68756.9
All*	Total formula weight	68756.9

*Water molecules are not included.