3QDZ
Crystal structure of the human thrombin mutant D102N in complex with the extracellular fragment of human PAR4.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Thrombin light chain | polymer | 31 | 3647.1 | 2 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain |
| 2 | B, D (B, D) | Thrombin heavy chain | polymer | 259 | 29779.2 | 2 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain |
| 3 | E, F (E, F) | Proteinase-activated receptor 4 | polymer | 9 | 952.1 | 2 | UniProt (Q96RI0) | Homo sapiens (human) | PAR-4, Coagulation factor II receptor-like 3, Thrombin receptor-like 3 |
Sequence modifications
B, D: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Asn 102 | Asp 462 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 68756.9 | |
| All* | Total formula weight | 68756.9 |
