3QDZ
Crystal structure of the human thrombin mutant D102N in complex with the extracellular fragment of human PAR4.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004252 | molecular_function | serine-type endopeptidase activity |
A | 0005576 | cellular_component | extracellular region |
A | 0006508 | biological_process | proteolysis |
A | 0007596 | biological_process | blood coagulation |
B | 0004252 | molecular_function | serine-type endopeptidase activity |
B | 0005509 | molecular_function | calcium ion binding |
B | 0006508 | biological_process | proteolysis |
B | 0007596 | biological_process | blood coagulation |
C | 0004252 | molecular_function | serine-type endopeptidase activity |
C | 0005576 | cellular_component | extracellular region |
C | 0006508 | biological_process | proteolysis |
C | 0007596 | biological_process | blood coagulation |
D | 0004252 | molecular_function | serine-type endopeptidase activity |
D | 0005509 | molecular_function | calcium ion binding |
D | 0006508 | biological_process | proteolysis |
D | 0007596 | biological_process | blood coagulation |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | SITE: Cleavage; by thrombin or trypsin => ECO:0000250 |
Chain | Residue | Details |
E | ARG47 | |
F | ARG47 | |
B | SER195 | |
D | HIS57 | |
D | ASN102 | |
D | SER195 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923 |
Chain | Residue | Details |
B | ASN60 | |
D | ASN60 |