8HZN
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8DYO
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![BU of 8dyo by Molmil](/molmil-images/mine/8dyo) | Cryo-EM structure of Importin-4 bound to RanGTP | Descriptor: | GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-4, ... | Authors: | Bernardes, N.E, Fung, H.Y.J, Li, Y, Chen, Z, Chook, Y.M. | Deposit date: | 2022-08-04 | Release date: | 2022-09-21 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (7.1 Å) | Cite: | Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex. Proc.Natl.Acad.Sci.USA, 119, 2022
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7YL2
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![BU of 7yl2 by Molmil](/molmil-images/mine/7yl2) | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004 | Descriptor: | Bromodomain-containing protein 4, GLYCEROL, N-(1-ethyl-2-oxidanylidene-3H-indol-5-yl)cyclohexanesulfonamide, ... | Authors: | Huang, Y, Wei, A, Dong, R, Xu, H, Zhang, C, Chen, Z, Li, J, Wu, X, Zhang, Y, Xu, Y. | Deposit date: | 2022-07-25 | Release date: | 2023-07-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004 To Be Published
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6V5T
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6V64
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![BU of 6v64 by Molmil](/molmil-images/mine/6v64) | Crystal structure of human thrombin bound to ppack with tryptophans replaced by 5-F-tryptophan | Descriptor: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, SODIUM ION, Thrombin heavy chain, ... | Authors: | Ruben, E.A, Chen, Z, Di Cera, E. | Deposit date: | 2019-12-04 | Release date: | 2020-05-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | 19F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2. J.Biol.Chem., 295, 2020
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1BXA
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![BU of 1bxa by Molmil](/molmil-images/mine/1bxa) | AMICYANIN REDUCED, PH 4.4, 1.3 ANGSTROMS | Descriptor: | COPPER (I) ION, PROTEIN (AMICYANIN) | Authors: | Cunane, L.M, Chen, Z.W, Durley, R.C.E, Mathews, F.S. | Deposit date: | 1998-10-01 | Release date: | 1998-10-07 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Molecular basis for interprotein complex-dependent effects on the redox properties of amicyanin. Biochemistry, 37, 1998
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8PNR
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![BU of 8pnr by Molmil](/molmil-images/mine/8pnr) | Structure of human KCTD15 BTB domain mutant G88D crystal form 1 | Descriptor: | BTB/POZ domain-containing protein KCTD15 | Authors: | Cruz Walma, D.A, Cros, J, Bradshaw, W, Richardson, W, Chen, Z, Chalk, R, Wilkie, A, Bullock, A.N. | Deposit date: | 2023-06-30 | Release date: | 2024-03-20 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | BTB domain mutations perturbing KCTD15 oligomerisation cause a distinctive frontonasal dysplasia syndrome. J Med Genet, 61, 2024
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6VLS
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![BU of 6vls by Molmil](/molmil-images/mine/6vls) | Structure of C-terminal fragment of Vip3A toxin | Descriptor: | DI(HYDROXYETHYL)ETHER, Maltose/maltodextrin-binding periplasmic protein,Vip3Aa | Authors: | Jiang, K, Zhang, Y, Chen, Z, Gao, X. | Deposit date: | 2020-01-25 | Release date: | 2020-07-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural and Functional Insights into the C-terminal Fragment of Insecticidal Vip3A Toxin ofBacillus thuringiensis. Toxins, 12, 2020
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6PXJ
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![BU of 6pxj by Molmil](/molmil-images/mine/6pxj) | Crystal structure of human thrombin mutant I16T | Descriptor: | GLYCEROL, MAGNESIUM ION, Thrombin heavy chain, ... | Authors: | Stojanovski, B, Chen, Z, Koester, S.K, Pelc, L.A, Di Cera, E. | Deposit date: | 2019-07-26 | Release date: | 2019-12-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Role of the I16-D194 ionic interaction in the trypsin fold. Sci Rep, 9, 2019
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6PX5
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![BU of 6px5 by Molmil](/molmil-images/mine/6px5) | CRYSTAL STRUCTURE OF HUMAN MEIZOTHROMBIN DESF1 MUTANT S195A bound with PPACK | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, Prothrombin, ... | Authors: | Pelc, L.A, Koester, S.K, Chen, Z, Gistover, N, Di Cera, E. | Deposit date: | 2019-07-24 | Release date: | 2019-09-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Residues W215, E217 and E192 control the allosteric E*-E equilibrium of thrombin. Sci Rep, 9, 2019
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6PXQ
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![BU of 6pxq by Molmil](/molmil-images/mine/6pxq) | Crystal structure of human thrombin mutant D194A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombin heavy chain, Thrombin light chain | Authors: | Stojanovski, B, Chen, Z, Koester, S.K, Pelc, L.A, Di Cera, E. | Deposit date: | 2019-07-26 | Release date: | 2019-12-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Role of the I16-D194 ionic interaction in the trypsin fold. Sci Rep, 9, 2019
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6A59
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![BU of 6a59 by Molmil](/molmil-images/mine/6a59) | Structure of histone demethylase REF6 at 1.8A | Descriptor: | Lysine-specific demethylase REF6, ZINC ION | Authors: | Tian, Z, Chen, Z. | Deposit date: | 2018-06-22 | Release date: | 2019-06-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Crystal structures of REF6 and its complex with DNA reveal diverse recognition mechanisms. Cell Discov, 6, 2020
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2JYU
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![BU of 2jyu by Molmil](/molmil-images/mine/2jyu) | Human Granulin C, isomer 2 | Descriptor: | Granulin-5 | Authors: | Tolkatchev, D, Wang, P, Chen, Z, Xu, P, Ni, F. | Deposit date: | 2007-12-19 | Release date: | 2008-04-22 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities. Protein Sci., 17, 2008
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1WVF
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![BU of 1wvf by Molmil](/molmil-images/mine/1wvf) | p-Cresol Methylhydroxylase: Alteration of the Structure of the Flavoprotein Subunit upon its Binding to the Cytochrome Subunit | Descriptor: | 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit, ACETIC ACID, CHLORIDE ION, ... | Authors: | Cunane, L.M, Chen, Z.-W, McIntire, W.S, Mathews, F.S. | Deposit date: | 2004-12-15 | Release date: | 2005-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | p-Cresol Methylhydroxylase: Alteration of the Structure of the Flavoprotein Subunit upon Its Binding to the Cytochrome Subunit Biochemistry, 44, 2005
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7W8M
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![BU of 7w8m by Molmil](/molmil-images/mine/7w8m) | Crystal structure of Co-type nitrile hydratase mutant from Pseudomonas thermophila - A129R | Descriptor: | COBALT (II) ION, Cobalt-containing nitrile hydratase subunit beta, Nitrile hydratase | Authors: | Ma, D, Cheng, Z.Y, Hou, X.D, Peplowski, L, Lai, Q.P, Fu, K, Yin, D.J, Rao, Y.J, Zhou, Z.M. | Deposit date: | 2021-12-08 | Release date: | 2022-08-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Insight into the broadened substrate scope of nitrile hydratase by static and dynamic structure analysis. Chem Sci, 13, 2022
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1Z71
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![BU of 1z71 by Molmil](/molmil-images/mine/1z71) | thrombin and P2 pyridine N-oxide inhibitor complex structure | Descriptor: | Hirudin IIIB', L17, thrombin | Authors: | Nantermet, P.G, Burgey, C.S, Robinson, K.A, Pellicore, J.M, Newton, C.L, Deng, J.Z, Lyle, T.A, Selnick, H.G, Lewis, S.D, Lucas, B.J, Krueger, J.A, Miller-Stein, C, White, R.B, Wong, B, McMasters, D.R, Wallace, A.A, Lynch Jr, J.J, Yan, Y, Chen, Z, Kuo, L, Gardell, S.J, Shafer, J.A, Vacca, J.P. | Deposit date: | 2005-03-23 | Release date: | 2005-05-17 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | P(2) pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold BIOORG.MED.CHEM.LETT., 15, 2005
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2JYT
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![BU of 2jyt by Molmil](/molmil-images/mine/2jyt) | Human Granulin C, isomer 1 | Descriptor: | Granulin-5 | Authors: | Tolkatchev, D, Wang, P, Chen, Z, Xu, P, Ni, F. | Deposit date: | 2007-12-19 | Release date: | 2008-04-22 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities. Protein Sci., 17, 2008
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7W8L
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![BU of 7w8l by Molmil](/molmil-images/mine/7w8l) | Crystal Structure of Co-type nitrile hydratase mutant from Pseudonocardia thermophila - M46R | Descriptor: | COBALT (II) ION, Cobalt-containing nitrile hydratase subunit beta, Nitrile hydratase | Authors: | Ma, D, Cheng, Z.Y, Hou, X.D, Peplowski, L, Lai, Q.P, Fu, K, Yin, D.J, Rao, Y.J, Zhou, Z.M. | Deposit date: | 2021-12-08 | Release date: | 2022-08-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Insight into the broadened substrate scope of nitrile hydratase by static and dynamic structure analysis. Chem Sci, 13, 2022
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1YIQ
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![BU of 1yiq by Molmil](/molmil-images/mine/1yiq) | Molecular cloning and structural analysis of quinohemoprotein alcohol dehydrogenase ADHIIG from Pseudomonas putida HK5. Compariison to the other quinohemoprotein alcohol dehydrogenase ADHIIB found in the same microorganism. | Descriptor: | CALCIUM ION, HEME C, PYRROLOQUINOLINE QUINONE, ... | Authors: | Toyama, H, Chen, Z.W, Fukumoto, M, Adachi, O, Matsushita, K, Mathews, F.S. | Deposit date: | 2005-01-12 | Release date: | 2005-08-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Molecular cloning and structural analysis of quinohemoprotein alcohol dehydrogenase ADH-IIG from Pseudomonas putida HK5 J.Mol.Biol., 352, 2005
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2JYV
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![BU of 2jyv by Molmil](/molmil-images/mine/2jyv) | Human Granulin F | Descriptor: | Granulin-2 | Authors: | Tolkatchev, D, Wang, P, Chen, Z, Xu, P, Ni, F. | Deposit date: | 2007-12-19 | Release date: | 2008-04-22 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities. Protein Sci., 17, 2008
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2JYE
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![BU of 2jye by Molmil](/molmil-images/mine/2jye) | Human Granulin A | Descriptor: | Granulin A | Authors: | Tolkatchev, D, Wang, P, Chen, Z, Xu, P, Ni, F. | Deposit date: | 2007-12-13 | Release date: | 2008-04-22 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities. Protein Sci., 17, 2008
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1AAC
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![BU of 1aac by Molmil](/molmil-images/mine/1aac) | AMICYANIN OXIDIZED, 1.31 ANGSTROMS | Descriptor: | AMICYANIN, COPPER (II) ION | Authors: | Cunane, L.M, Chen, Z.-W, Durley, R.C.E, Mathews, F.S. | Deposit date: | 1995-09-07 | Release date: | 1996-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | X-ray structure of the cupredoxin amicyanin, from Paracoccus denitrificans, refined at 1.31 A resolution. Acta Crystallogr.,Sect.D, 52, 1996
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1WVE
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![BU of 1wve by Molmil](/molmil-images/mine/1wve) | p-Cresol Methylhydroxylase: Alteration of the Structure of the Flavoprotein Subunit upon its Binding to the Cytochrome Subunit | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-cresol dehydrogenase [hydroxylating] cytochrome c subunit, 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit, ... | Authors: | Cunane, L.M, Chen, Z.-W, McIntire, W.S, Mathews, F.S. | Deposit date: | 2004-12-15 | Release date: | 2005-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | p-Cresol Methylhydroxylase: Alteration of the Structure of the Flavoprotein Subunit upon Its Binding to the Cytochrome Subunit Biochemistry, 44, 2005
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6C2W
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![BU of 6c2w by Molmil](/molmil-images/mine/6c2w) | Crystal structure of human prothrombin mutant S101C/A470C | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Prothrombin, ... | Authors: | Chinnaraj, M, Chen, Z, Pelc, L, Grese, Z, Bystranowska, D, Di Cera, E, Pozzi, N. | Deposit date: | 2018-01-09 | Release date: | 2018-02-28 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (4.12 Å) | Cite: | Structure of prothrombin in the closed form reveals new details on the mechanism of activation. Sci Rep, 8, 2018
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6CQS
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![BU of 6cqs by Molmil](/molmil-images/mine/6cqs) | Sediminispirochaeta smaragdinae SPS-1 metallo-beta-lactamase | Descriptor: | Beta-lactamase, ZINC ION | Authors: | Page, R.C, VanPelt, J, Cheng, Z, Crowder, M.W. | Deposit date: | 2018-03-16 | Release date: | 2018-08-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A Noncanonical Metal Center Drives the Activity of the Sediminispirochaeta smaragdinae Metallo-beta-lactamase SPS-1. Biochemistry, 57, 2018
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