8HBN
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7QXM
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8PVA
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![BU of 8pva by Molmil](/molmil-images/mine/8pva) | Structure of bacterial ribosome determined by cryoEM at 100 keV | 分子名称: | 16S rRNA, 23S rRNA, 50S ribosomal protein L14, ... | 著者 | McMullan, G, Naydenova, K, Mihaylov, D, Peet, M.J, Wilson, H, Yamashita, K, Dickerson, J.L, Chen, S, Cannone, G, Lee, Y, Hutchings, K.A, Gittins, O, Sobhy, M, Wells, T, El-Gomati, M.M, Dalby, J, Meffert, M, Schulze-Briese, C, Henderson, R, Russo, C.J. | 登録日 | 2023-07-17 | 公開日 | 2023-11-29 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Structure determination by cryoEM at 100 keV. Proc.Natl.Acad.Sci.USA, 120, 2023
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5LS6
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![BU of 5ls6 by Molmil](/molmil-images/mine/5ls6) | Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor | 分子名称: | 1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide, Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2, Jarid2 K116me3, ... | 著者 | Zhang, Y, Justin, N, Chen, S, Wilson, J, Gamblin, S. | 登録日 | 2016-08-22 | 公開日 | 2017-02-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.47 Å) | 主引用文献 | Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas. J. Med. Chem., 59, 2016
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8BQV
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![BU of 8bqv by Molmil](/molmil-images/mine/8bqv) | Cryo-EM structure of alpha-synuclein singlet filament from Juvenile-onset synucleinopathy | 分子名称: | Alpha-synuclein, Unknown protein | 著者 | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | 登録日 | 2023-01-18 | 公開日 | 2023-02-22 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2 Å) | 主引用文献 | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy. Acta Neuropathol, 145, 2023
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8BG9
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![BU of 8bg9 by Molmil](/molmil-images/mine/8bg9) | Murine amyloid-beta filaments with the Arctic mutation (E22G) from APP(NL-G-F) mouse brains | ABeta | 分子名称: | Amyloid-beta protein 40 | 著者 | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. | 登録日 | 2022-10-27 | 公開日 | 2023-01-18 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
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8BG0
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![BU of 8bg0 by Molmil](/molmil-images/mine/8bg0) | Amyloid-beta tetrameric filaments with the Arctic mutation (E22G) from Alzheimer's disease brains | ABeta40 | 分子名称: | Amyloid-beta precursor protein | 著者 | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. | 登録日 | 2022-10-27 | 公開日 | 2023-01-18 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (1.99 Å) | 主引用文献 | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
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8BFZ
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![BU of 8bfz by Molmil](/molmil-images/mine/8bfz) | Amyloid-beta 42 filaments extracted from the human brain with Arctic mutation (E22G) of Alzheimer's disease | ABeta42 | 分子名称: | Amyloid-beta precursor protein | 著者 | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordberg, A, Goedert, M, Scheres, S.H.W. | 登録日 | 2022-10-27 | 公開日 | 2023-01-18 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
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8BQW
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![BU of 8bqw by Molmil](/molmil-images/mine/8bqw) | Cryo-EM structure of alpha-synuclein filaments doublet from Juvenile-onset synucleinopathy | 分子名称: | Alpha-synuclein, Unknown protein | 著者 | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | 登録日 | 2023-01-18 | 公開日 | 2023-02-22 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy. Acta Neuropathol, 145, 2023
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8IW5
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![BU of 8iw5 by Molmil](/molmil-images/mine/8iw5) | Crystal structure of liprin-beta H2H3 dimer | 分子名称: | CALCIUM ION, Liprin-beta-1 | 著者 | Zhang, J, Chen, S, Wei, Z. | 登録日 | 2023-03-29 | 公開日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | KANK1 shapes focal adhesions by orchestrating protein binding, mechanical force sensing, and phase separation. Cell Rep, 42, 2023
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8IW0
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![BU of 8iw0 by Molmil](/molmil-images/mine/8iw0) | Crystal structure of the KANK1/liprin-beta1 complex | 分子名称: | Liprin-beta-1,KN motif and ankyrin repeat domain-containing protein 1 | 著者 | Zhang, J, Chen, S, Wei, Z, Yu, C. | 登録日 | 2023-03-29 | 公開日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | KANK1 shapes focal adhesions by orchestrating protein binding, mechanical force sensing, and phase separation. Cell Rep, 42, 2023
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8CE7
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![BU of 8ce7 by Molmil](/molmil-images/mine/8ce7) | Type1 alpha-synuclein filament assembled in vitro by wild-type and mutant (7 residues insertion) protein | 分子名称: | Alpha-synuclein | 著者 | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | 登録日 | 2023-02-01 | 公開日 | 2023-03-01 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy. Acta Neuropathol, 145, 2023
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4X3Q
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![BU of 4x3q by Molmil](/molmil-images/mine/4x3q) | Crystal structure of S-adenosylmethionine-dependent methyltransferase SibL in complex with SAH | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, SibL | 著者 | liu, J.S, Chen, S.C, Yang, C.S, Huang, C.H, Chen, Y. | 登録日 | 2014-12-01 | 公開日 | 2015-11-25 | 実験手法 | X-RAY DIFFRACTION (2.586 Å) | 主引用文献 | Crystal structure of S-adenosylmethionine-dependent methyltransferase SibL in complex with SAH To Be Published, 2015
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8IAH
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![BU of 8iah by Molmil](/molmil-images/mine/8iah) | Structure of mammalian spectrin-actin junctional complex of membrane skeleton, State I, Global map | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | 著者 | Li, N, Chen, S, Gao, N. | 登録日 | 2023-02-08 | 公開日 | 2023-05-03 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of membrane skeleton organization in red blood cells. Cell, 186, 2023
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8IAI
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![BU of 8iai by Molmil](/molmil-images/mine/8iai) | Structure of mammalian spectrin-actin junctional complex of membrane skeleton, State II, Global map | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | 著者 | Li, N, Chen, S, Gao, N. | 登録日 | 2023-02-08 | 公開日 | 2023-05-03 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis of membrane skeleton organization in red blood cells. Cell, 186, 2023
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8QDO
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![BU of 8qdo by Molmil](/molmil-images/mine/8qdo) | Crystal structure of the tegument protein UL82 (pp71) from Human Cytomegalovirus | 分子名称: | Protein pp71, TETRAETHYLENE GLYCOL | 著者 | Bresch, I.P, Eberhage, J, Reubold, T.F, Eschenburg, S. | 登録日 | 2023-08-30 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of the tegument protein UL82 (pp71) from human cytomegalovirus. Protein Sci., 33, 2024
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8K8A
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8K89
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![BU of 8k89 by Molmil](/molmil-images/mine/8k89) | Crystal structure of NFIL3 | 分子名称: | Nuclear factor interleukin-3-regulated protein | 著者 | Min, J.R, Chen, S.Z, Liu, K. | 登録日 | 2023-07-29 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for specific DNA sequence recognition by the transcription factor NFIL3. J.Biol.Chem., 300, 2024
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8K86
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![BU of 8k86 by Molmil](/molmil-images/mine/8k86) | Crystal structure of NFIL3 in complex with TTATGTAA DNA | 分子名称: | DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*TP*AP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*TP*AP*CP*AP*TP*AP*AP*TP*G)-3'), Nuclear factor interleukin-3-regulated protein | 著者 | Min, J.R, Chen, S.Z, Liu, K. | 登録日 | 2023-07-28 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Structural basis for specific DNA sequence recognition by the transcription factor NFIL3. J.Biol.Chem., 300, 2024
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8K8D
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7A8V
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![BU of 7a8v by Molmil](/molmil-images/mine/7a8v) | Crystal structure of Polysaccharide monooxygenase from P.verruculosum | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, Lytic polysaccharide monooxygenase, ... | 著者 | Nemashkalov, V, Kravchenko, O, Gabdulkhakov, A, Tischenko, S, Rozhkova, A, Sinitsyn, A. | 登録日 | 2020-08-31 | 公開日 | 2021-10-06 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.94961083 Å) | 主引用文献 | Crystal structure of Polysaccharide monooxygenase from P.verruculosum To Be Published
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5BR4
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![BU of 5br4 by Molmil](/molmil-images/mine/5br4) | E. coli lactaldehyde reductase (FucO) M185C mutant | 分子名称: | CHLORIDE ION, GLYCEROL, Lactaldehyde reductase, ... | 著者 | Cahn, J.K.B, Brinkmann-Chen, S, Arnold, F.H. | 登録日 | 2015-05-29 | 公開日 | 2015-12-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (0.91 Å) | 主引用文献 | Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes. Protein Eng.Des.Sel., 29, 2016
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7NRV
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![BU of 7nrv by Molmil](/molmil-images/mine/7nrv) | Paired helical filament from Alzheimer's disease with PET ligand APN-1607 | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2021-03-04 | 公開日 | 2021-03-24 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta Neuropathol, 141, 2021
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7NRX
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![BU of 7nrx by Molmil](/molmil-images/mine/7nrx) | Straight filament from Alzheimer's disease with PET ligand APN-1607 | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2021-03-04 | 公開日 | 2021-03-24 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | 主引用文献 | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta Neuropathol, 141, 2021
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7QJW
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