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PDB: 3972 件
5MY8
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BU of 5my8 by Molmil
Crystal structure of SRPK1 in complex with SPHINX31
分子名称: 1,2-ETHANEDIOL, CITRIC ACID, DIMETHYL SULFOXIDE, ...
著者Chaikuad, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Knapp, S, Structural Genomics Consortium (SGC)
登録日2017-01-25
公開日2017-05-10
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
ACS Chem. Biol., 12, 2017
4Q0N
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BU of 4q0n by Molmil
Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand
分子名称: (2E)-1-(2-hydroxyphenyl)-3-(2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)prop-2-en-1-one, 1,2-ETHANEDIOL, Protein polybromo-1
著者Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Monteiro, O, Fedorov, O, Chaikuad, A, Yue, W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
登録日2014-04-02
公開日2014-05-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand
To be Published
8PDI
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BU of 8pdi by Molmil
The phosphatase and C2 domains of SHIP1 with covalent Z1763271112
分子名称: (5-phenyl-1,3,4-thiadiazol-2-yl)methanimine, DIMETHYL SULFOXIDE, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
著者Bradshaw, W.J, Moreira, T, Pascoa, T.C, Bountra, C, Chalk, R, von Delft, F, Brennan, P.E, Gileadi, O.
登録日2023-06-12
公開日2023-07-26
最終更新日2024-04-17
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.
Structure, 32, 2024
3C5K
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BU of 3c5k by Molmil
Crystal structure of human HDAC6 zinc finger domain
分子名称: Histone deacetylase 6, ZINC ION
著者Dong, A, Ravichandran, M, Schuetz, A, Loppnau, P, Li, Y, MacKenzie, F, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Dhe-Paganon, S, Min, J, Ouyang, H, Structural Genomics Consortium (SGC)
登録日2008-01-31
公開日2008-02-19
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Crystal Structure of Human HDAC6 zinc finger domain.
To be Published
3CLV
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BU of 3clv by Molmil
Crystal Structure of Rab5a from plasmodium falciparum, PFB0500c
分子名称: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, Rab5 protein, ...
著者Chattopadhyay, D, Wernimont, A.K, Langsley, G, Lew, J, Kozieradzki, I, Cossar, D, Schapira, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Sukumar, D, Structural Genomics Consortium (SGC)
登録日2008-03-20
公開日2008-07-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Crystal Structure of Rab5a from plasmodium falciparum, PFB0500c
To be Published
4MVT
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BU of 4mvt by Molmil
Crystal structure of SUMO E3 Ligase PIAS3
分子名称: CHLORIDE ION, E3 SUMO-protein ligase PIAS3, UNKNOWN ATOM OR ION, ...
著者Dong, A, Hu, J, Li, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
登録日2013-09-24
公開日2013-10-16
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of SUMO E3 Ligase PIAS3
to be published
3DWD
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BU of 3dwd by Molmil
Crystal structure of the ArfGAP domain of human ARFGAP1
分子名称: ADP-ribosylation factor GTPase-activating protein 1, UNKNOWN ATOM OR ION, ZINC ION
著者Nedyalkova, L, Tong, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Wilkstrom, M, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2008-07-22
公開日2008-08-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the ArfGAP domain of human ARFGAP1
To be Published
3DZ8
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BU of 3dz8 by Molmil
Crystal structure of human Rab3B GTPase bound with GDP
分子名称: GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Rab-3B, UNKNOWN ATOM OR ION
著者Shen, Y, Tong, Y, Sukumar, D, Tempel, W, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Wilkstrom, M, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2008-07-29
公開日2008-08-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of human Rab3B GTPase bound with GDP
To be Published
3DAX
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BU of 3dax by Molmil
Crystal structure of human CYP7A1
分子名称: Cytochrome P450 7A1, PROTOPORPHYRIN IX CONTAINING FE, UNKNOWN ATOM OR ION
著者Strushkevich, N.V, Tempel, W, Dombrovski, L, Dong, A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Wilkstrom, M, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2008-05-30
公開日2008-08-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal structure of human CYP7A1
To be Published
3DFA
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BU of 3dfa by Molmil
Crystal structure of kinase domain of calcium-dependent protein kinase cgd3_920 from Cryptosporidium parvum
分子名称: Calcium-dependent protein kinase cgd3_920
著者Wernimont, A.K, Lew, J, Lin, Y.H, Hassanali, A, Khuu, C, Alam, Z, Kozieradzki, I, Cossar, D, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Wilkstrom, M, Edwards, A.M, Hui, R, Artz, J.D, Xiao, T, Structural Genomics Consortium (SGC)
登録日2008-06-11
公開日2008-07-29
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystal structure of kinase domain of calcium-dependent protein kinase cgd3_920 from Cryptosporidium parvum.
To be Published
3DL9
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BU of 3dl9 by Molmil
Crystal structure of CYP2R1 in complex with 1-alpha-hydroxy-vitamin D2
分子名称: (1S,3R,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraene-1,3-diol, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), Cytochrome P450 2R1, ...
著者Strushkevich, N.V, Tempel, W, Gilep, A.A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Wilkstrom, M, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2008-06-26
公開日2008-08-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.721 Å)
主引用文献Crystal structure of CYP2R1 in complex with 1-alpha-hydroxy-vitamin D2.
To be Published
3T7L
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BU of 3t7l by Molmil
Crystal structure of the FYVE domain of endofin (ZFYVE16) at 1.1A resolution
分子名称: 1,2-ETHANEDIOL, ZINC ION, Zinc finger FYVE domain-containing protein 16
著者Chaikuad, A, Williams, E, Guo, K, Sanvitale, C, Berridge, G, Krojer, T, Muniz, J.R.C, Canning, P, Phillips, C, Shrestha, A, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC)
登録日2011-07-30
公開日2011-08-31
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.09 Å)
主引用文献Crystal structure of the FYVE domain of endofin (ZFYVE16) at 1.1A resolution
To be Published
3CON
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BU of 3con by Molmil
Crystal structure of the human NRAS GTPase bound with GDP
分子名称: GTPase NRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Nedyalkova, L, Tong, Y, Tempel, W, Shen, L, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2008-03-28
公開日2008-04-08
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.649 Å)
主引用文献Crystal structure of the human NRAS GTPase bound with GDP.
To be Published
3DZQ
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BU of 3dzq by Molmil
Human EphA3 kinase domain in complex with inhibitor AWL-II-38.3
分子名称: EPH receptor A3, N-[2-methyl-5-({[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]carbonyl}amino)phenyl]isoxazole-5-carboxamide
著者Walker, J.R, Syeda, F, Gray, N, Mansoor, W, Mackenzie, F, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2008-07-30
公開日2008-08-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Kinase Domain of Human Ephrin Type-A Receptor 3 (Epha3) in Complex with ALW-II-38-3.
To be Published
3ECI
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BU of 3eci by Molmil
Microtubule-associated protein 1 light chain 3 alpha isoform A (MAP1ALC3)
分子名称: Microtubule-associated protein 1 light chain 3 alpha
著者Walker, J.R, Davis, T.L, Mujib, S, Butler-Cole, C, Tempel, W, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Botchkarev, A, Dhe-Paganon, S.
登録日2008-08-30
公開日2008-10-14
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Human Autophagy-Related Protein LC3 A
To be Published
3EDT
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BU of 3edt by Molmil
Crystal structure of the mutated S328N hKLC2 TPR domain
分子名称: Kinesin light chain 2, UNKNOWN ATOM OR ION
著者Zhu, H, Shen, Y, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2008-09-03
公開日2009-02-10
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of mutated S328N TPR domain of human kinesin light chain 2
To be published
3TUG
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BU of 3tug by Molmil
Crystal structure of the HECT domain of ITCH E3 ubiquitin ligase
分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase Itchy homolog, UNKNOWN ATOM OR ION
著者Dong, A, Dobrovetsky, E, Xue, S, Butler, C, Wernimont, A, Walker, J.R, Tempel, W, Dhe-Paganon, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Tong, Y, Structural Genomics Consortium (SGC)
登録日2011-09-16
公開日2011-10-12
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Crystal structure of the HECT domain of ITCH E3 ubiquitin ligase
To be Published
3U1U
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BU of 3u1u by Molmil
Crystal structure of RNA polymerase-associated protein RTF1 homolog Plus-3 domain
分子名称: GLYCEROL, RNA polymerase-associated protein RTF1 homolog, SULFATE ION, ...
著者Guo, Y, Tempel, W, Bian, C, Wernimont, A.K, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2011-09-30
公開日2012-04-04
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of RNA polymerase-associated protein RTF1 homolog Plus-3 domain
to be published
4NXJ
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BU of 4nxj by Molmil
Crystal Structure of PF3D7_1475600, a bromodomain from Plasmodium Falciparum
分子名称: Bromodomain protein
著者Wernimont, A.K, Loppnau, P, Knapp, S, Fonseca, M, Brennan, P.E, Dong, A, Walker, J.R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, Structural Genomics Consortium (SGC)
登録日2013-12-09
公開日2014-03-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Crystal Structure of PF3D7_1475600, a bromodomain from Plasmodium Falciparum
TO BE PUBLISHED
6ZFH
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BU of 6zfh by Molmil
Structure of human galactokinase in complex with galactose and 2'-(benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'H-spiro[cyclopentane-1,4'-quinazolin]-5'(6'H)-one
分子名称: 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclopentane]-5-one, Galactokinase, beta-D-galactopyranose
著者Bezerra, G.A, Mackinnon, S, Zhang, M, Foster, W, Bailey, H, Arrowsmith, C, Edwards, A, Bountra, C, Lai, K, Yue, W.W, Structural Genomics Consortium (SGC)
登録日2020-06-17
公開日2021-06-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.439 Å)
主引用文献Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.
Acs Chem.Biol., 16, 2021
3S95
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BU of 3s95 by Molmil
Crystal structure of the human LIMK1 kinase domain in complex with staurosporine
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ...
著者Beltrami, A, Chaikuad, A, Daga, N, Elkins, J.M, Mahajan, P, Savitsky, P, Vollmar, M, Krojer, T, Muniz, J.R.C, Fedorov, O, Allerston, C.K, Yue, W.W, Gileadi, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Bullock, A, Structural Genomics Consortium (SGC)
登録日2011-05-31
公開日2011-07-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of the human LIMK1 kinase domain in complex with staurosporine
To be Published
4NR2
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BU of 4nr2 by Molmil
Crystal structure of STK4 (MST1) SARAH domain
分子名称: 1,2-ETHANEDIOL, Serine/threonine-protein kinase 4
著者Chaikuad, A, Krojer, T, Kopec, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
登録日2013-11-26
公開日2014-01-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of STK4 (MST1) SARAH domain
To be Published
3S93
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BU of 3s93 by Molmil
Crystal structure of conserved motif in TDRD5
分子名称: Tudor domain-containing protein 5, UNKNOWN ATOM OR ION
著者Chao, X, Tempel, W, Bian, C, Kania, J, Wernimont, A.K, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2011-05-31
公開日2011-08-31
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Crystal structure of conserved motif in TDRD5
to be published
4NYX
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BU of 4nyx by Molmil
Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand
分子名称: (3R)-N-[3-(7-methoxy-3,4-dihydroquinolin-1(2H)-yl)propyl]-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxamide, CREB-binding protein
著者Filippakopoulos, P, Picaud, S, Felletar, I, Rooney, T.P.C, Fedorov, O, Martin, S, Monteiro, O.P, Conway, S.J, von Delft, F, Brennan, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
登録日2013-12-11
公開日2014-01-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand
TO BE PUBLISHED
4NYV
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BU of 4nyv by Molmil
Crystal Structure of the Bromodomain of human CREBBP in complex with a quinazolin-one ligand
分子名称: 6-bromo-3-methyl-3,4-dihydroquinazolin-2(1H)-one, CREB-binding protein
著者Filippakopoulos, P, Picaud, S, Felletar, I, Fedorov, O, Martin, S, Monteiro, O.P, von Delft, F, Brennan, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC)
登録日2013-12-11
公開日2014-01-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Crystal Structure of the Bromodomain of human CREBBP in complex with a quinazolin-one ligand
TO BE PUBLISHED

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