Crystal structure of human HDAC6 zinc finger domain

Summary for 3C5K

DescriptorHistone deacetylase 6, ZINC ION (3 entities in total)
Functional Keywordshdac6, zinc finger, actin-binding, chromatin regulator, cytoplasm, hydrolase, metal-binding, nucleus, phosphoprotein, repressor, transcription, transcription regulation, ubl conjugation, zinc-finger, structural genomics, structural genomics consortium, sgc
Biological sourceHomo sapiens (human)
Cellular locationNucleus Q9UBN7
Total number of polymer chains1
Total molecular weight12364.1
Primary citation
Dong, A.,Ravichandran, M.,Schuetz, A.,Loppnau, P.,Li, Y.,MacKenzie, F.,Kozieradzki, I.,Edwards, A.M.,Arrowsmith, C.H.,Weigelt, J.,Bountra, C.,Bochkarev, A.,Dhe-Paganon, S.,Min, J.,Ouyang, H.
Crystal Structure of Human HDAC6 zinc finger domain.
To be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2141 1.9% 1.1% 5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-10-14