4NYV

Crystal Structure of the Bromodomain of human CREBBP in complex with a quinazolin-one ligand

Summary for 4NYV

• Entry DOI: 10.2210/pdb4nyv/pdb
• Related: 4NYW 4NYX
• Descriptor: CREB-binding protein, 6-bromo-3-methyl-3,4-dihydroquinazolin-2(1H)-one (3 entities in total)
• Functional Keywords: crebbp, creb binding, kat3a, rsts, rst, bromodomain, transcription, structural genomics consortium, sgc
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q92793
• Total number of polymer chains: 4
• Total formula weight: 57857.74

Authors

Filippakopoulos, P.,Picaud, S.,Felletar, I.,Fedorov, O.,Martin, S.,Monteiro, O.P.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-12-11, release date: 2014-01-29, Last modification date: 2023-09-20)

• Primary citation: Filippakopoulos, P.,Picaud, S.,Felletar, I.,Fedorov, O.,Martin, S.,Monteiro, O.P.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.; Crystal Structure of the Bromodomain of human CREBBP in complex with a quinazolin-one ligand; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (1.83 Å)