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4NYX

Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand

Summary for 4NYX
Entry DOI10.2210/pdb4nyx/pdb
Related4NYV 4NYW
DescriptorCREB-binding protein, (3R)-N-[3-(7-methoxy-3,4-dihydroquinolin-1(2H)-yl)propyl]-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxamide (3 entities in total)
Functional Keywordscrebbp, creb binding, kat3a, rsts, rst, bromodomain, transcription, structural genomics consortium, sgc
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q92793
Total number of polymer chains1
Total formula weight14631.84
Authors
Primary citationFilippakopoulos, P.,Picaud, S.,Felletar, I.,Rooney, T.P.C.,Fedorov, O.,Martin, S.,Monteiro, O.P.,Conway, S.J.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.
Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand
TO BE PUBLISHED,
Experimental method
X-RAY DIFFRACTION (1.1 Å)
Structure validation

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PDB entries from 2024-03-27

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