4NYX

Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand

Summary for 4NYX

• Entry DOI: 10.2210/pdb4nyx/pdb
• Related: 4NYV 4NYW
• Descriptor: CREB-binding protein, (3R)-N-[3-(7-methoxy-3,4-dihydroquinolin-1(2H)-yl)propyl]-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxamide (3 entities in total)
• Functional Keywords: crebbp, creb binding, kat3a, rsts, rst, bromodomain, transcription, structural genomics consortium, sgc
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q92793
• Total number of polymer chains: 1
• Total formula weight: 14631.84

Authors

Filippakopoulos, P.,Picaud, S.,Felletar, I.,Rooney, T.P.C.,Fedorov, O.,Martin, S.,Monteiro, O.P.,Conway, S.J.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-12-11, release date: 2014-01-29, Last modification date: 2023-09-20)

• Primary citation: Filippakopoulos, P.,Picaud, S.,Felletar, I.,Rooney, T.P.C.,Fedorov, O.,Martin, S.,Monteiro, O.P.,Conway, S.J.,von Delft, F.,Brennan, P.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.; Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (1.1 Å)