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4NYV

Crystal Structure of the Bromodomain of human CREBBP in complex with a quinazolin-one ligand

Functional Information from GO Data
ChainGOidnamespacecontents
A0004402molecular_functionhistone acetyltransferase activity
A0006355biological_processregulation of DNA-templated transcription
B0004402molecular_functionhistone acetyltransferase activity
B0006355biological_processregulation of DNA-templated transcription
C0004402molecular_functionhistone acetyltransferase activity
C0006355biological_processregulation of DNA-templated transcription
D0004402molecular_functionhistone acetyltransferase activity
D0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE 15E A 1201
ChainResidue
APRO1110
AVAL1115
ATYR1125
AASN1168
AVAL1174
AHOH1312

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE 15E B 1201
ChainResidue
BASN1168
BVAL1174
BHOH1337
BPRO1110
BVAL1115
BLEU1120

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE 15E C 1201
ChainResidue
CPRO1110
CVAL1115
CLEU1120
CASN1168
CARG1173
CVAL1174
CHOH1306

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE 15E D 1201
ChainResidue
DPRO1110
DVAL1115
DLEU1120
DASN1168
DVAL1174
DHOH1308

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY
ChainResidueDetails
ASER1108-TYR1167

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues428
DetailsDomain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues184
DetailsRegion: {"description":"Interaction with histone","evidences":[{"source":"PubMed","id":"24361270","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues72
DetailsRegion: {"description":"Interaction with ASF1A","evidences":[{"source":"PubMed","id":"24616510","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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