4NYV
Crystal Structure of the Bromodomain of human CREBBP in complex with a quinazolin-one ligand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004402 | molecular_function | histone acetyltransferase activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0004402 | molecular_function | histone acetyltransferase activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0004402 | molecular_function | histone acetyltransferase activity |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0004402 | molecular_function | histone acetyltransferase activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 15E A 1201 |
| Chain | Residue |
| A | PRO1110 |
| A | VAL1115 |
| A | TYR1125 |
| A | ASN1168 |
| A | VAL1174 |
| A | HOH1312 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 15E B 1201 |
| Chain | Residue |
| B | ASN1168 |
| B | VAL1174 |
| B | HOH1337 |
| B | PRO1110 |
| B | VAL1115 |
| B | LEU1120 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 15E C 1201 |
| Chain | Residue |
| C | PRO1110 |
| C | VAL1115 |
| C | LEU1120 |
| C | ASN1168 |
| C | ARG1173 |
| C | VAL1174 |
| C | HOH1306 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 15E D 1201 |
| Chain | Residue |
| D | PRO1110 |
| D | VAL1115 |
| D | LEU1120 |
| D | ASN1168 |
| D | VAL1174 |
| D | HOH1308 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. SlpFrqpvDpqllgipDYFdiVknpMdlstIkrkldtgq..Yqepwqyvddvwl.MfnNAwlY |
| Chain | Residue | Details |
| A | SER1108-TYR1167 |
