3DZQ

Human EphA3 kinase domain in complex with inhibitor AWL-II-38.3

Summary for 3DZQ

• Entry DOI: 10.2210/pdb3dzq/pdb
• Related: 2GSF 2QO2 2QO7 2QO9 2QOC 2QOD 2QOF 2QOI 2QOK 2QOL 2QON 2QOO 2QOQ
• Descriptor: EPH receptor A3, N-[2-methyl-5-({[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]carbonyl}amino)phenyl]isoxazole-5-carboxamide (3 entities in total)
• Functional Keywords: receptor tyrosine kinase, structural genomics consortium, sgc, atp-binding, membrane, nucleotide binding, phosphorylation, transferase, transmembrane, tyrosine-protein kinase, inhibitor-complex, nucleotide-binding, phosphoprotein
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 40927.60

Authors

Walker, J.R.,Syeda, F.,Gray, N.,Mansoor, W.,Mackenzie, F.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-07-30, release date: 2008-08-26, Last modification date: 2023-08-30)

• Primary citation: Walker, J.R.,Syeda, F.,Gray, N.,Mansoor, W.,Mackenzie, F.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.; Kinase Domain of Human Ephrin Type-A Receptor 3 (Epha3) in Complex with ALW-II-38-3.; To be Published,

Experimental method

X-RAY DIFFRACTION (1.75 Å)