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3DZQ

Human EphA3 kinase domain in complex with inhibitor AWL-II-38.3

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE IFC A 1001
ChainResidue
APHE632
ATHR699
AGLU700
AMET702
ATYR742
AHIS744
ALEU753
ASER763
AASP764
APHE765
AHOH1237
AALA651
AGLU670
AILE673
AMET674
APHE677
AILE682
AILE683
AILE697

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues27
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGAGEFGEVCsGrlklpskkeis.......VAIK
ChainResidueDetails
AVAL627-LYS653

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLAARNILI
ChainResidueDetails
ATYR742-ILE754

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI2
Number of Residues12
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"18547520","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AARG750
AASP746

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP746
AALA748

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1ir3
ChainResidueDetails
AASP746
AASN751
AALA748

247947

PDB entries from 2026-01-21

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