3DZQ

Human EphA3 kinase domain in complex with inhibitor AWL-II-38.3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	EPH receptor A3	polymer	361	40458.2	1	UniProt (Q6P4R6) Pfam (PF07714) Pfam (PF07647) UniProt (by SIFTS) (P29320) In PDB	Homo sapiens
2	A	N-[2-methyl-5-({[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]carbonyl}amino)phenyl]isoxazole-5-carboxamide	non-polymer		469.4	1	Chemie (IFC)
3		water	water		18.0	286	Chemie (HOH)

Sequence modifications

A: 606 - 947 (UniProt: Q6P4R6)

PDB	External Database	Details
Met 587	-	expression tag
Gly 588	-	expression tag
Ser 589	-	expression tag
Ser 590	-	expression tag
His 591	-	expression tag
His 592	-	expression tag
His 593	-	expression tag
His 594	-	expression tag
His 595	-	expression tag
His 596	-	expression tag
Ser 597	-	expression tag
Ser 598	-	expression tag
Gly 599	-	expression tag
Leu 600	-	expression tag
Val 601	-	expression tag
Pro 602	-	expression tag
Arg 603	-	expression tag
Gly 604	-	expression tag
Ser 605	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40458.2
Non-Polymers*	Number of molecules	1
	Total formula weight	469.4
All*	Total formula weight	40927.6

*Water molecules are not included.