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PDB: 98 results
1V0C
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BU of 1v0c by Molmil
Structure of AAC(6')-Ib in complex with Kanamycin C and AcetylCoA.
Descriptor: AAC(6')-IB, ACETYL COENZYME *A, CALCIUM ION, ...
Authors:Vetting, M.W, Park, C.H, Hedge, S.S, Hooper, D.C, Blanchard, J.S.
Deposit date:2008-03-20
Release date:2008-09-02
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanistic and Structural Analysis of Aminoglycoside N-Acetyltransferase Aac(6')-Ib and its Bifunctional, Fluoroquinolone-Active Aac(6')-Ib-Cr Variant.
Biochemistry, 47, 2008
1DIH
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BU of 1dih by Molmil
THREE-DIMENSIONAL STRUCTURE OF E. COLI DIHYDRODIPICOLINATE REDUCTASE
Descriptor: DIHYDRODIPICOLINATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Scapin, G, Blanchard, J.S, Sacchettini, J.C.
Deposit date:1994-09-14
Release date:1995-09-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase.
Biochemistry, 34, 1995
1S7K
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BU of 1s7k by Molmil
RimL- Ribosomal L7/L12 alpha-N-protein acetyltransferase crystal form 2 (apo)
Descriptor: acetyl transferase
Authors:Vetting, M.W, de Carvalho, L.P, Roderick, S.L, Blanchard, J.S.
Deposit date:2004-01-29
Release date:2005-03-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A novel dimeric structure of the RimL Nalpha-acetyltransferase from Salmonella typhimurium.
J.Biol.Chem., 280, 2005
3NDE
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BU of 3nde by Molmil
Crystal Structure of BlaC-E166A covalently bound with Cephalotin
Descriptor: (2R)-5-[(acetyloxy)methyl]-2-{(1R)-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
Authors:Tremblay, L.W, Blanchard, J.S.
Deposit date:2010-06-07
Release date:2011-12-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:BlaC-E166A covalently bound with cephalosporins and penicillins
To be Published
3NCK
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BU of 3nck by Molmil
Crystal Structure of BlaC-E166A covalently bound with Nafcillin
Descriptor: (2R,4S)-2-[(1R)-1-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase
Authors:Tremblay, L.W, Blanchard, J.S.
Deposit date:2010-06-04
Release date:2011-12-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:BlaC-E166A covalently bound with cephalosporins and penicillins
To be Published
3NC8
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BU of 3nc8 by Molmil
Crystal Structure of BlaC-E166A covalently bound with Mecillinam
Descriptor: 2-[(1R)-1-{[(E)-azepan-1-ylmethylidene]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
Authors:Tremblay, L.W, Blanchard, J.S.
Deposit date:2010-06-04
Release date:2011-12-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:BlaC-E166A covalently bound with cephalosporins and penicillins
To be Published
3N8S
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BU of 3n8s by Molmil
Crystal Structure of BlaC-E166A covalently bound with Cefamandole
Descriptor: (2R)-2-[(1R)-1-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-2-oxoethyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
Authors:Tremblay, L.W, Blanchard, J.S.
Deposit date:2010-05-28
Release date:2010-11-24
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the Michaelis Complex (1.2 A) and the Covalent Acyl Intermediate (2.0 A) of Cefamandole Bound in the Active Sites of the Mycobacterium tuberculosis beta-Lactamase K73A and E166A Mutants.
Biochemistry, 49, 2010
3NDG
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BU of 3ndg by Molmil
Crystal Structure of BlaC-E166A covalently bound with Methicillin
Descriptor: (2R,4S)-2-[(1R)-1-{[(2,6-dimethoxyphenyl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
Authors:Tremblay, L.W, Blanchard, J.S.
Deposit date:2010-06-07
Release date:2011-12-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:BlaC-E166A covalently bound with cephalosporins and penicillins
To be Published
3NBL
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BU of 3nbl by Molmil
Crystal Structure of BlaC-E166A covalently bound with Cefuroxime
Descriptor: (2R)-5-[(carbamoyloxy)methyl]-2-[(1R)-1-{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}-2-oxoethyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase
Authors:Tremblay, L.W, Blanchard, J.S.
Deposit date:2010-06-03
Release date:2011-12-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:BlaC-E166A covalently bound with cephalosporins and penicillins
To be Published
3M6B
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BU of 3m6b by Molmil
Crystal Structure of the Ertapenem Pre-isomerized Covalent Adduct with TB B-lactamase
Descriptor: (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION
Authors:Tremblay, L.W, Fan, F, Blanchard, J.S.
Deposit date:2010-03-15
Release date:2010-04-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.
Biochemistry, 49, 2010
3NY4
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BU of 3ny4 by Molmil
Crystal Structure of BlaC-K73A bound with Cefamandole
Descriptor: (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, Beta-lactamase, PHOSPHATE ION
Authors:Tremblay, L.W, Blanchard, J.S.
Deposit date:2010-07-14
Release date:2010-11-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Structures of the Michaelis Complex (1.2 A) and the Covalent Acyl Intermediate (2.0 A) of Cefamandole Bound in the Active Sites of the Mycobacterium tuberculosis beta-Lactamase K73A and E166A Mutants.
Biochemistry, 49, 2010
3N6I
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BU of 3n6i by Molmil
Crystal Structure of BlaC-E166A covalently bound with 6-aminopenicillian
Descriptor: (2R,4S)-2-[(1R)-1-amino-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
Authors:Tremblay, L.W, Blanchard, J.S.
Deposit date:2010-05-25
Release date:2011-12-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Structure Activity Relationship of BlaC with all classes of beta-lactams
To be Published
3N8R
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BU of 3n8r by Molmil
Crystal Structure of BlaC-E166A covalently bound with Carbenicillin
Descriptor: (2R,4S)-2-[(1R)-1-{[(2S)-2-carboxy-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
Authors:Tremblay, L.W, Blanchard, J.S.
Deposit date:2010-05-28
Release date:2011-12-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:BlaC-E166A bound with beta-lactams from all classes
To be Published
3N8L
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BU of 3n8l by Molmil
Crystal Structure of BlaC-E166A covalently bound with Ampicillin
Descriptor: (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
Authors:Tremblay, L.W, Blanchard, J.S.
Deposit date:2010-05-28
Release date:2011-12-14
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structures of BlaC-E166A covalently bound to beta-lactams from all classes.
To be Published
3N7W
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BU of 3n7w by Molmil
Crystal Structure of BlaC-E166A covalently bound with Amoxicillin
Descriptor: 2-{1-[2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-2-OXO-ETHYL}-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, Beta-lactamase, PHOSPHATE ION
Authors:Tremblay, L.W, Blanchard, J.S.
Deposit date:2010-05-27
Release date:2011-12-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:BlaC-E166A Bound with btea-lactams of all classes
To be Published
4LZJ
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BU of 4lzj by Molmil
Crystal Structure of MurQ from H.influenzae with bound inhibitor
Descriptor: 2-(acetylamino)-3-O-[(1R)-1-carboxyethyl]-2-deoxy-6-O-phosphono-D-glucitol, N-acetylmuramic acid 6-phosphate etherase, PHOSPHATE ION
Authors:Hazra, S, Blanchard, J.
Deposit date:2013-07-31
Release date:2014-02-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:Structure of MurNAc 6-phosphate hydrolase (MurQ) from Haemophilus influenzae with a bound inhibitor.
Biochemistry, 52, 2013
4M0D
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BU of 4m0d by Molmil
Crystal structure of MurQ from H.influenzae in apo form
Descriptor: N-acetylmuramic acid 6-phosphate etherase
Authors:Hazra, S, Blanchard, J.
Deposit date:2013-08-01
Release date:2014-02-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.577 Å)
Cite:Structure of MurNAc 6-phosphate hydrolase (MurQ) from Haemophilus influenzae with a bound inhibitor.
Biochemistry, 52, 2013
1BWZ
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BU of 1bwz by Molmil
DIAMINOPIMELATE EPIMERASE FROM HEMOPHILUS INFLUENZAE
Descriptor: PROTEIN (DIAMINOPIMELATE EPIMERASE)
Authors:Cirilli, M, Zheng, R, Scapin, G, Blanchard, J.S.
Deposit date:1998-09-29
Release date:1998-12-16
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structural symmetry: the three-dimensional structure of Haemophilus influenzae diaminopimelate epimerase.
Biochemistry, 37, 1998
1C3V
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BU of 1c3v by Molmil
DIHYDRODIPICOLINATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND PDC
Descriptor: DIHYDRODIPICOLINATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PYRIDINE-2,6-DICARBOXYLIC ACID, ...
Authors:Cirilli, M, Zheng, R, Scapin, G, Blanchard, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:1999-07-28
Release date:2003-08-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity
Biochemistry, 42, 2003
1ENY
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BU of 1eny by Molmil
CRYSTAL STRUCTURE AND FUNCTION OF THE ISONIAZID TARGET OF MYCOBACTERIUM TUBERCULOSIS
Descriptor: ENOYL-ACYL CARRIER PROTEIN (ACP) REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Dessen, A, Quemard, A, Blanchard, J.S, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:1995-01-27
Release date:1996-01-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.
Science, 267, 1995
1ENZ
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BU of 1enz by Molmil
CRYSTAL STRUCTURE AND FUNCTION OF THE ISONIAZID TARGET OF MYCOBACTERIUM TUBERCULOSIS
Descriptor: ENOYL-ACYL CARRIER PROTEIN (ACP) REDUCTASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Dessen, A, Quemard, A, Blanchard, J.S, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:1995-01-27
Release date:1996-01-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.
Science, 267, 1995
4JLF
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BU of 4jlf by Molmil
Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase
Descriptor: Beta-lactamase, PHOSPHATE ION
Authors:Hazra, S, Kurz, S, Blanchard, J, Bonomo, R.
Deposit date:2013-03-12
Release date:2013-10-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations.
Antimicrob.Agents Chemother., 57, 2013
4HCX
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BU of 4hcx by Molmil
Structure of ICDH-1 from M.tuberculosis complexed with NADPH & Mn2+
Descriptor: CHLORIDE ION, Isocitrate dehydrogenase [NADP], MANGANESE (II) ION, ...
Authors:Hazra, S, Blanchard, J.
Deposit date:2012-10-01
Release date:2013-02-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural, Kinetic and Chemical Mechanism of Isocitrate Dehydrogenase-1 from Mycobacterium tuberculosis.
Biochemistry, 52, 2013
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