4JLF
Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase
Summary for 4JLF
Entry DOI | 10.2210/pdb4jlf/pdb |
Related | 2GDN |
Descriptor | Beta-lactamase, PHOSPHATE ION (3 entities in total) |
Functional Keywords | beta-lactams inactivation, tuberculosis, drug design, multi drug resistance, hydrolase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 1 |
Total formula weight | 28661.46 |
Authors | Hazra, S.,Kurz, S.,Blanchard, J.,Bonomo, R. (deposition date: 2013-03-12, release date: 2013-10-30, Last modification date: 2023-09-20) |
Primary citation | Kurz, S.G.,Wolff, K.A.,Hazra, S.,Bethel, C.R.,Hujer, A.M.,Smith, K.M.,Xu, Y.,Tremblay, L.W.,Blanchard, J.S.,Nguyen, L.,Bonomo, R.A. Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations. Antimicrob.Agents Chemother., 57:6085-6096, 2013 Cited by PubMed: 24060876DOI: 10.1128/AAC.01253-13 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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