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3M6B

Crystal Structure of the Ertapenem Pre-isomerized Covalent Adduct with TB B-lactamase

Summary for 3M6B
Entry DOI10.2210/pdb3m6b/pdb
Related3M6H 3cg5 3dwz
DescriptorBeta-lactamase, PHOSPHATE ION, (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, ... (4 entities in total)
Functional Keywordsalpha-beta structure, antibiotic resistance, cell membrane, hydrolase, lipoprotein, membrane, palmitate, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological sourceMycobacterium tuberculosis
Total number of polymer chains1
Total formula weight29417.73
Authors
Tremblay, L.W.,Fan, F.,Blanchard, J.S. (deposition date: 2010-03-15, release date: 2010-04-14, Last modification date: 2023-09-06)
Primary citationTremblay, L.W.,Fan, F.,Blanchard, J.S.
Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.
Biochemistry, 49:3766-3773, 2010
Cited by
PubMed: 20353175
DOI: 10.1021/bi100232q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.3 Å)
Structure validation

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