1V0C

Structure of AAC(6')-Ib in complex with Kanamycin C and AcetylCoA.

Summary for 1V0C

• Entry DOI: 10.2210/pdb1v0c/pdb
• Related: 2BUE 2VQY
• Descriptor: AAC(6')-IB, ACETYL COENZYME *A, KANAMYCIN C, ... (5 entities in total)
• Functional Keywords: gnat, transferase, aminoglycoside, fluoroquinolone, acetyltransferase, antibiotic resistance
• Biological source: ESCHERICHIA COLI
• Total number of polymer chains: 1
• Total formula weight: 23759.26

Authors

Vetting, M.W.,Park, C.H.,Hedge, S.S.,Hooper, D.C.,Blanchard, J.S. (deposition date: 2008-03-20, release date: 2008-09-02, Last modification date: 2019-03-06)

• Primary citation: Vetting, M.W.,Park, C.H.,Hegde, S.S.,Jacoby, G.A.,Hooper, D.C.,Blanchard, J.S.; Mechanistic and Structural Analysis of Aminoglycoside N-Acetyltransferase Aac(6')-Ib and its Bifunctional, Fluoroquinolone-Active Aac(6')-Ib-Cr Variant.; Biochemistry, 47:9825-, 2008; PubMed: 18710261; DOI: 10.1021/BI800664X

Experimental method

X-RAY DIFFRACTION (2.2 Å)