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PDB: 151 件
3ZJF
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A20 OTU domain with irreversibly oxidised Cys103 from 270 min H2O2 soak.
分子名称: A20P50, CHLORIDE ION
著者Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D.
登録日2013-01-17
公開日2013-03-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
3ZJD
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A20 OTU domain in reduced, active state at 1.87 A resolution
分子名称: 1,2-ETHANEDIOL, A20P50, CHLORIDE ION
著者Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D.
登録日2013-01-17
公開日2013-03-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
3ZJG
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A20 OTU domain with irreversibly oxidised Cys103 from 60 min H2O2 soak.
分子名称: CHLORIDE ION, TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3
著者Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D.
登録日2013-01-17
公開日2013-03-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
4ADY
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BU of 4ady by Molmil
Crystal structure of 26S proteasome subunit Rpn2
分子名称: 26S PROTEASOME REGULATORY SUBUNIT RPN2
著者Kulkarni, K, He, J, Da Fonseca, P.C.A, Krutauz, D, Glickman, M.H, Barford, D, Morris, E.P.
登録日2012-01-04
公開日2012-03-14
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The Structure of the 26S Proteasome Subunit Rpn2 Reveals its Pc Repeat Domain as a Closed Toroid of Two Concentric Alpha-Helical Rings
Structure, 20, 2012
4A2N
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BU of 4a2n by Molmil
Crystal Structure of Ma-ICMT
分子名称: CARDIOLIPIN, ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE, PALMITIC ACID, ...
著者Yang, J, Kulkarni, K, Manolaridis, I, Zhang, Z, Dodd, R.B, Mas-Droux, C, Barford, D.
登録日2011-09-27
公開日2012-01-11
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Mechanism of Isoprenylcysteine Carboxyl Methylation from the Crystal Structure of the Integral Membrane Methyltransferase Icmt.
Mol.Cell, 44, 2011
3ZN3
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BU of 3zn3 by Molmil
N-terminal domain of S. pombe Cdc23 APC subunit
分子名称: ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, MERCURY (II) ION
著者Zhang, Z, Yang, J, Conin, N, Kulkarni, K, Barford, D.
登録日2013-02-13
公開日2013-02-20
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The Four Canonical Tpr Subunits of Human Apc/C Form Related Homo-Dimeric Structures and Stack in Parallel to Form a Tpr Suprahelix
J.Mol.Biol., 425, 2013
1BZH
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BU of 1bzh by Molmil
Cyclic peptide inhibitor of human PTP1B
分子名称: PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR), PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B)
著者Groves, M.R, Yao, Z.J, Burke Jr, T.R, Barford, D.
登録日1998-10-28
公開日1999-02-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1BZC
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HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI
分子名称: 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE)
著者Groves, M.R, Yao, Z.J, Jr Burke, T.R, Barford, D.
登録日1998-10-27
公開日1999-02-16
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
2W9N
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crystal structure of linear di-ubiquitin
分子名称: CHLORIDE ION, UBIQUITIN, ZINC ION
著者Komander, D, Reyes-Turcu, F, Wilkinson, K.D, Barford, D.
登録日2009-01-27
公開日2009-04-28
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Molecular Discrimination of Structurally Equivalent Lys 63-Linked and Linear Polyubiquitin Chains.
Embo Rep., 10, 2009
1RPM
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BU of 1rpm by Molmil
HUMAN RECEPTOR PROTEIN TYROSINE PHOSPHATASE MU, DOMAIN 1
分子名称: RECEPTOR PROTEIN TYROSINE PHOSPHATASE MU
著者Hoffmann, K.M.V, Tonks, N.K, Barford, D.
登録日1997-09-11
公開日1998-04-01
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The crystal structure of domain 1 of receptor protein-tyrosine phosphatase mu.
J.Biol.Chem., 272, 1997
2V0P
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BU of 2v0p by Molmil
The Structure of Tap42 Alpha4 Subunit
分子名称: TYPE 2A PHOSPHATASE-ASSOCIATED PROTEIN 42, ZINC ION
著者Roe, S.M, Yang, J, Barford, D.
登録日2007-05-15
公開日2007-07-17
最終更新日2019-05-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Structure of Tap42/Alpha4 Reveals a Tetratricopeptide Repeat-Like Fold and Provides Insights Into Pp2A Regulation.
Biochemistry, 46, 2007
2VFK
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BU of 2vfk by Molmil
AKAP18 delta central domain - AMP
分子名称: ADENOSINE MONOPHOSPHATE, AKAP18 DELTA
著者Gold, M.G, Smith, F.D, Scott, J.D, Barford, D.
登録日2007-11-05
公開日2008-05-06
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Akap18 Contains a Phosphoesterase Domain that Binds AMP
J.Mol.Biol., 375, 2008
2V55
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Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure
分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Komander, D, Garg, R, Wan, P.T.C, Ridley, A.J, Barford, D.
登録日2008-10-01
公開日2008-11-04
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3.705 Å)
主引用文献Mechanism of Multi-Site Phosphorylation from a Rock-I:Rhoe Complex Structure.
Embo J., 27, 2008
1B3U
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BU of 1b3u by Molmil
CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA
分子名称: PROTEIN (PROTEIN PHOSPHATASE PP2A)
著者Groves, M.R, Hanlon, N, Turowski, P, Hemmings, B, Barford, D.
登録日1998-12-14
公開日1999-04-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.
Cell(Cambridge,Mass.), 96, 1999
2VFY
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BU of 2vfy by Molmil
AKAP18 delta central domain
分子名称: AKAP18 DELTA
著者Gold, M.G, Smith, F.D, Scott, J.D, Barford, D.
登録日2007-11-06
公開日2008-05-06
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Akap18 Contains a Phosphoesterase Domain that Binds AMP
J.Mol.Biol., 375, 2008
2VFL
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BU of 2vfl by Molmil
AKAP18 delta central domain - CMP
分子名称: AKAP18 DELTA, CYTIDINE-5'-MONOPHOSPHATE
著者Gold, M.G, Smith, F.D, Scott, J.D, Barford, D.
登録日2007-11-05
公開日2008-05-06
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Akap18 Contains a Phosphoesterase Domain that Binds AMP
J.Mol.Biol., 375, 2008
2VFJ
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Structure of the A20 Ovarian Tumour (OTU) domain
分子名称: MAGNESIUM ION, SULFATE ION, TUMOR NECROSIS FACTOR
著者Komander, D, Barford, D.
登録日2007-11-04
公開日2007-12-04
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure of the A20 Otu Domain and Mechanistic Insights Into Deubiquitination
Biochem.J., 409, 2008
1OEO
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BU of 1oeo by Molmil
PTP1B with the catalytic cysteine oxidized to sulfonic acid
分子名称: PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1
著者Salmeen, A, Andersen, J.N, Myers, M.P, Meng, T.C, Hinks, J.A, Tonks, N.K, Barford, D.
登録日2003-03-28
公開日2003-06-12
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Redox Regulation of Protein Tyrosine Phosphatase Involves a Sulfenyl-Amide Intermediate
Nature, 423, 2003
2W42
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BU of 2w42 by Molmil
THE STRUCTURE OF A PIWI PROTEIN FROM ARCHAEOGLOBUS FULGIDUS COMPLEXED WITH A 16NT DNA DUPLEX.
分子名称: 5'-D(*GP*TP*CP*GP*AP*AP*TP*TP)-3', 5'-D(*TP*TP*CP*GP*AP*CP*GP*CP)-3', MANGANESE (II) ION, ...
著者Parker, J.S, Roe, S.M, Barford, D.
登録日2008-11-19
公開日2008-12-09
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Enhancement of the Seed-Target Recognition Step in RNA Silencing by a Piwi-Mid Domain Protein
Mol.Cell, 33, 2009
2UW6
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BU of 2uw6 by Molmil
Structure of PKA-PKB chimera complexed with (S)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine
分子名称: (2S)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ...
著者Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A.
登録日2007-03-19
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery
J.Med.Chem., 50, 2007
2UW4
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BU of 2uw4 by Molmil
Structure of PKA-PKB chimera complexed with 2-(4-(5-methyl-1H-pyrazol- 4-yl)-phenyl)-ethylamine
分子名称: 2-[4-(3-METHYL-1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ...
著者Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A.
登録日2007-03-19
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery
J.Med.Chem., 50, 2007
2UW5
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Structure of PKA-PKB chimera complexed with (R)-2-(4-chloro-phenyl)- 2-(4-1H-pyrazol-4-yl)-phenyl)-ethylamine
分子名称: (2R)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ...
著者Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A.
登録日2007-03-19
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery
J.Med.Chem., 50, 2007
2UW7
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BU of 2uw7 by Molmil
Structure of PKA-PKB chimera complexed with 4-(4-chloro-phenyl)-4-(4- (1H-pyrazol-4-yl)-phenyl)-piperidine
分子名称: 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ...
著者Davies, T.G, Saxty, G, Woodhead, S.J, Berdini, V, Verdonk, M.L, Wyatt, P.G, Boyle, R.G, Barford, D, Downham, R, Garrett, M.D, Carr, R.A.
登録日2007-03-19
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery
J.Med.Chem., 50, 2007
2VSZ
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Crystal Structure of the ELMO1 PH domain
分子名称: ENGULFMENT AND CELL MOTILITY PROTEIN 1
著者Komander, D, Patel, M, Barford, D, Cote, J.-F.
登録日2008-05-01
公開日2009-03-10
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献An Alpha-Helical Extension of the Elmo1 Pleckstrin Homology Domain Mediates Direct Interaction to Dock180 and is Critical in Rac Signaling.
Molecular Biology of the Cell, 19, 2008
2VHF
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Structure of the CYLD USP domain
分子名称: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE CYLD, ZINC ION
著者Komander, D, Lord, C.J, Scheel, H, Swift, S, Hofmann, K, Ashworth, A, Barford, D.
登録日2007-11-21
公開日2008-03-11
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The Structure of the Cyld Usp Domain Explains its Specificity for Lys63-Linked Polyubiquitin and Reveals a B-Box Module
Mol.Cell.Biol., 29, 2008

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