1G1F

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A TRI-PHOSPHORYLATED PEPTIDE (RDI(PTR)ETD(PTR)(PTR)RK) FROM THE INSULIN RECEPTOR KINASE

Summary for 1G1F

DescriptorPROTEIN TYROSINE PHOSPHATASE 1B, TRI-PHOSPHORYLATED PEPTIDE FROM THE INSULIN RECEPTOR KINASE (3 entities in total)
Functional Keywordshydrolase (phosphorylation), tyrosine phosphatase, peptide complex, hydrolase, signaling protein
Biological sourceHomo sapiens (human)
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Cellular locationEndoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side P18031
Total number of polymer chains2
Total molecular weight36453.1
Authors
Salmeen, A.,Andersen, J.N.,Myers, M.P.,Tonks, N.K.,Barford, D. (deposition date: 2000-10-11, release date: 2001-01-17, Last modification date: 2011-07-13)
Primary citation
Salmeen, A.,Andersen, J.N.,Myers, M.P.,Tonks, N.K.,Barford, D.
Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6:1401-1412, 2000
PubMed: 11163213 (PDB entries with the same primary citation)
DOI: 10.1016/S1097-2765(00)00137-4
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers2 0.3% 3.7% 4.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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169117
PDB entries from 2020-09-23