1G1F

CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A TRI-PHOSPHORYLATED PEPTIDE (RDI(PTR)ETD(PTR)(PTR)RK) FROM THE INSULIN RECEPTOR KINASE

Summary for 1G1F

• Entry DOI: 10.2210/pdb1g1f/pdb
• Descriptor: PROTEIN TYROSINE PHOSPHATASE 1B, TRI-PHOSPHORYLATED PEPTIDE FROM THE INSULIN RECEPTOR KINASE (3 entities in total)
• Functional Keywords: hydrolase (phosphorylation), tyrosine phosphatase, peptide complex, hydrolase, signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: P18031
• Total number of polymer chains: 2
• Total formula weight: 36453.10

Authors

Salmeen, A.,Andersen, J.N.,Myers, M.P.,Tonks, N.K.,Barford, D. (deposition date: 2000-10-11, release date: 2001-01-17, Last modification date: 2021-11-03)

• Primary citation: Salmeen, A.,Andersen, J.N.,Myers, M.P.,Tonks, N.K.,Barford, D.; Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.; Mol.Cell, 6:1401-1412, 2000; PubMed: 11163213; DOI: 10.1016/S1097-2765(00)00137-4

Experimental method

X-RAY DIFFRACTION (2 Å)