8U4C
 
 | | Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric conformation. | | 分子名称: | Insulin receptor, Insulin-like growth factor II | | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | | 登録日 | 2023-09-10 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
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7MOA
 | | Cryo-EM structure of the c-MET II/HGF I complex bound with HGF II in a rigid conformation | | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor | | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | | 登録日 | 2021-05-01 | | 公開日 | 2021-06-09 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
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7MO7
 | | Cryo-EM structure of 2:2 c-MET/HGF holo-complex | | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor | | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | | 登録日 | 2021-05-01 | | 公開日 | 2021-06-09 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
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7MO9
 | | Cryo-EM map of the c-MET II/HGF I/HGF II (K4 and SPH) sub-complex | | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor | | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | | 登録日 | 2021-05-01 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
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7MOB
 | | Cryo-EM structure of 2:2 c-MET/NK1 complex | | 分子名称: | Hepatocyte growth factor, Hepatocyte growth factor receptor | | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | | 登録日 | 2021-05-01 | | 公開日 | 2021-06-09 | | 最終更新日 | 2021-07-28 | | 実験手法 | ELECTRON MICROSCOPY (5 Å) | | 主引用文献 | Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
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7MO8
 | | Cryo-EM structure of 1:1 c-MET I/HGF I complex after focused 3D refinement of holo-complex | | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hepatocyte growth factor, Hepatocyte growth factor receptor | | 著者 | Uchikawa, E, Chen, Z.M, Xiao, G.Y, Zhang, X.W, Bai, X.C. | | 登録日 | 2021-05-01 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Structural basis of the activation of c-MET receptor.
Nat Commun, 12, 2021
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8VJB
 | | Cryo-EM structure of short form insulin receptor (IR-A) with four IGF2 bound, symmetric conformation. | | 分子名称: | Insulin-like growth factor II, Isoform Short of Insulin receptor | | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | | 登録日 | 2024-01-06 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
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8VJC
 | | Cryo-EM structure of short form insulin receptor (IR-A) with three IGF2 bound, asymmetric conformation. | | 分子名称: | Insulin-like growth factor II, Isoform Short of Insulin receptor | | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | | 登録日 | 2024-01-06 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2.
Nat Commun, 15, 2024
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6WG3
 | | Cryo-EM structure of human Cohesin-NIPBL-DNA complex | | 分子名称: | Cohesin subunit SA-1, DNA (51-MER), Double-strand-break repair protein rad21 homolog, ... | | 著者 | Shi, Z.B, Gao, H, Bai, X.C, Yu, H. | | 登録日 | 2020-04-04 | | 公開日 | 2020-05-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (5.3 Å) | | 主引用文献 | Cryo-EM structure of the human cohesin-NIPBL-DNA complex.
Science, 368, 2020
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6WGE
 | | Cryo-EM structure of human Cohesin-NIPBL-DNA complex without STAG1 | | 分子名称: | DNA (43-MER), Double-strand-break repair protein rad21 homolog, MAGNESIUM ION, ... | | 著者 | Shi, Z.B, Gao, H, Bai, X.C, Yu, H. | | 登録日 | 2020-04-05 | | 公開日 | 2020-05-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cryo-EM structure of the human cohesin-NIPBL-DNA complex.
Science, 368, 2020
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8EZ0
 | | Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Symmetric conformation | | 分子名称: | Insulin, Insulin receptor | | 著者 | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | | 登録日 | 2022-10-29 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.
Elife, 11, 2022
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8EYX
 | | Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S; denoted as IR-3CS) Asymmetric conformation 1 | | 分子名称: | Insulin, Insulin receptor | | 著者 | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | | 登録日 | 2022-10-29 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.
Elife, 11, 2022
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8EYR
 | | Cryo-EM structure of two IGF1 bound full-length mouse IGF1R mutant (four glycine residues inserted in the alpha-CT; IGF1R-P674G4): symmetric conformation | | 分子名称: | Insulin-like growth factor 1 receptor, Insulin-like growth factor I | | 著者 | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | | 登録日 | 2022-10-28 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.
Elife, 11, 2022
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8EYY
 | | Cryo-EM structure of 4 insulins bound full-length mouse IR mutant with physically decoupled alpha CTs (C684S/C685S/C687S, denoted as IR-3CS) Asymmetric conformation 2 | | 分子名称: | Insulin, Insulin receptor | | 著者 | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | | 登録日 | 2022-10-29 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor.
Elife, 11, 2022
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7K36
 | | Cryo-EM structure of STRIPAK complex | | 分子名称: | INOSITOL HEXAKISPHOSPHATE, MANGANESE (II) ION, MOB-like protein phocein, ... | | 著者 | Jeong, B.-C, Bai, X.C. | | 登録日 | 2020-09-10 | | 公開日 | 2021-03-10 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structure of the Hippo signaling integrator human STRIPAK.
Nat.Struct.Mol.Biol., 28, 2021
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6D80
 | | Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri bound to saposin | | 分子名称: | CALCIUM ION, Mitochondrial calcium uniporter, Saposin A | | 著者 | Nguyen, N.X, Armache, J.-P, Cheng, Y, Bai, X.C. | | 登録日 | 2018-04-25 | | 公開日 | 2018-07-11 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (5 Å) | | 主引用文献 | Cryo-EM structure of a fungal mitochondrial calcium uniporter.
Nature, 559, 2018
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6D7W
 | | Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri at 3.8 Angstrom resolution | | 分子名称: | CALCIUM ION, Mitochondrial calcium uniporter | | 著者 | Nguyen, N.X, Armache, J.-P, Cheng, Y, Bai, X.C. | | 登録日 | 2018-04-25 | | 公開日 | 2018-07-11 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-EM structure of a fungal mitochondrial calcium uniporter.
Nature, 559, 2018
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3J6B
 | | Structure of the yeast mitochondrial large ribosomal subunit | | 分子名称: | 21S ribosomal RNA, 54S ribosomal protein IMG1, mitochondrial, ... | | 著者 | Amunts, A, Brown, A, Bai, X.C, Llacer, J.L, Hussain, T, Emsley, P, Long, F, Murshudov, G, Scheres, S.H.W, Ramakrishnan, V. | | 登録日 | 2014-01-22 | | 公開日 | 2014-04-09 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structure of the yeast mitochondrial large ribosomal subunit.
Science, 343, 2014
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3J7A
 | | Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein eS1, 40S ribosomal protein eS10, ... | | 著者 | Wong, W, Bai, X.C, Brown, A, Fernandez, I.S, Hanssen, E, Condron, M, Tan, Y.H, Baum, J, Scheres, S.H.W. | | 登録日 | 2014-06-03 | | 公開日 | 2014-07-16 | | 最終更新日 | 2018-07-18 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
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3J79
 | | Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, large subunit | | 分子名称: | 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | 著者 | Wong, W, Bai, X.C, Brown, A, Fernandez, I.S, Hanssen, E, Condron, M, Tan, Y.H, Baum, J, Scheres, S.H.W. | | 登録日 | 2014-06-02 | | 公開日 | 2014-07-16 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.
Elife, 3, 2014
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3J7Y
 | | Structure of the large ribosomal subunit from human mitochondria | | 分子名称: | 16S rRNA, ADENOSINE MONOPHOSPHATE, CRIF1, ... | | 著者 | Brown, A, Amunts, A, Bai, X.C, Sugimoto, Y, Edwards, P.C, Murshudov, G, Scheres, S.H.W, Ramakrishnan, V. | | 登録日 | 2014-08-26 | | 公開日 | 2014-10-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure of the large ribosomal subunit from human mitochondria.
Science, 346, 2014
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5GAM
 | | Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, ... | | 著者 | Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K. | | 登録日 | 2015-12-15 | | 公開日 | 2016-02-03 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Angstrom resolution
Nature, 530, 2016
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5GAO
 | | Head region of the yeast spliceosomal U4/U6.U5 tri-snRNP | | 分子名称: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2, Saccharomyces cerevisiae strain UOA_M2 chromosome 5 sequence, ... | | 著者 | Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K. | | 登録日 | 2015-12-15 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
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5GAN
 | | The overall structure of the yeast spliceosomal U4/U6.U5 tri-snRNP at 3.7 Angstrom | | 分子名称: | 13 kDa ribonucleoprotein-associated protein, GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-processing factor 31, ... | | 著者 | Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K. | | 登録日 | 2015-12-15 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
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6Q2R
 | | Cryo-EM structure of RET/GFRa2/NRTN extracellular complex in the tetrameric form | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha-2, ... | | 著者 | Li, J, Shang, G.J, Chen, Y.J, Brautigam, C.A, Liou, J, Zhang, X.W, Bai, X.C. | | 登録日 | 2019-08-08 | | 公開日 | 2019-10-02 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Elife, 8, 2019
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