7MO8

Cryo-EM structure of 1:1 c-MET I/HGF I complex after focused 3D refinement of holo-complex

Summary for 7MO8

Entry DOI	10.2210/pdb7mo8/pdb
EMDB information	23920
Descriptor	Hepatocyte growth factor, Hepatocyte growth factor receptor, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose (3 entities in total)
Functional Keywords	c-met, hgf, receptor tyrosine kinase, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	240720.88
Authors	Uchikawa, E.,Chen, Z.M.,Xiao, G.Y.,Zhang, X.W.,Bai, X.C. (deposition date: 2021-05-01, release date: 2021-06-09, Last modification date: 2021-07-28)
Primary citation	Uchikawa, E.,Chen, Z.,Xiao, G.Y.,Zhang, X.,Bai, X.C. Structural basis of the activation of c-MET receptor. Nat Commun, 12:4074-4074, 2021 Cited by PubMed: 34210960 DOI: 10.1038/s41467-021-24367-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.5 Å)

Structure validation