3GIC
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![BU of 3gic by Molmil](/molmil-images/mine/3gic) | Structure of thrombin mutant delta(146-149e) in the free form | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombin heavy chain, Thrombin light chain | Authors: | Bah, A, Carrell, C.J, Chen, Z, Gandhi, P.S, Di Cera, E. | Deposit date: | 2009-03-05 | Release date: | 2009-06-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Stabilization of the E* form turns thrombin into an anticoagulant. J.Biol.Chem., 284, 2009
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2PV9
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![BU of 2pv9 by Molmil](/molmil-images/mine/2pv9) | Crystal structure of murine thrombin in complex with the extracellular fragment of murine PAR4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Proteinase-activated receptor 4, Thrombin heavy chain, ... | Authors: | Bah, A, Chen, Z, Bush-Pelc, L.A, Mathews, F.S, Di Cera, E. | Deposit date: | 2007-05-09 | Release date: | 2007-07-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2PUX
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![BU of 2pux by Molmil](/molmil-images/mine/2pux) | Crystal structure of murine thrombin in complex with the extracellular fragment of murine PAR3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Proteinase-activated receptor 3, Thrombin heavy chain, ... | Authors: | Bah, A, Chen, Z, Bush-Pelc, L.A, Mathews, F.S, Di Cera, E. | Deposit date: | 2007-05-09 | Release date: | 2007-07-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2MX4
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![BU of 2mx4 by Molmil](/molmil-images/mine/2mx4) | NMR structure of Phosphorylated 4E-BP2 | Descriptor: | Eukaryotic translation initiation factor 4E-binding protein 2 | Authors: | Bah, A, Forman-Kay, J, Vernon, R, Siddiqui, Z, Krzeminski, M, Muhandiram, R, Zhao, C, Sonenberg, N, Kay, L. | Deposit date: | 2014-12-10 | Release date: | 2015-01-07 | Last modified: | 2015-03-18 | Method: | SOLUTION NMR | Cite: | Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch. Nature, 519, 2015
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6O6I
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![BU of 6o6i by Molmil](/molmil-images/mine/6o6i) | |
1C6W
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![BU of 1c6w by Molmil](/molmil-images/mine/1c6w) | MAUROCALCIN FROM SCORPIO MAURUS | Descriptor: | MAUROCALCIN | Authors: | Mosbah, A, Kharrat, R, Fajloun, Z, Renisio, J.-G, Blanc, E, Sabatier, J.-M, Ayeb, M, Darbon, H. | Deposit date: | 1999-12-23 | Release date: | 2000-09-06 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | A new fold in the scorpion toxin family, associated with an activity on a ryanodine-sensitive calcium channel. Proteins, 40, 2000
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3NPS
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![BU of 3nps by Molmil](/molmil-images/mine/3nps) | |
3NJQ
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![BU of 3njq by Molmil](/molmil-images/mine/3njq) | |
1K19
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![BU of 1k19 by Molmil](/molmil-images/mine/1k19) | NMR Solution Structure of the Chemosensory Protein CSP2 from Moth Mamestra brassicae | Descriptor: | Chemosensory Protein CSP2 | Authors: | Mosbah, A, Campanacci, V, Lartigue, A, Tegoni, M, Cambillau, C, Darbon, H. | Deposit date: | 2001-09-24 | Release date: | 2002-12-04 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution structure of a chemosensory protein from the moth Mamestra brassicae BIOCHEM.J., 369, 2003
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1PJV
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![BU of 1pjv by Molmil](/molmil-images/mine/1pjv) | Cobatoxin 1 from Centruroides noxius Scorpion venom: Chemical Synthesis, 3-D Structure in Solution, Pharmacology and Docking on K+ channels | Descriptor: | Cobatoxin 1 | Authors: | Mosbah, A, Jouirou, B, Visan, V, Grissmer, S, El Ayeb, M, Rochat, H, De Waard, M, Mabrouk, K, Sabatier, J.M. | Deposit date: | 2003-06-03 | Release date: | 2004-03-09 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels. Biochem.J., 377, 2004
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1Q01
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![BU of 1q01 by Molmil](/molmil-images/mine/1q01) | Lebetin peptides, a new class of potent aggregation inhibitors | Descriptor: | lebetin 2 isoform alpha | Authors: | Mosbah, A, Marrakchi, N, Ganzalez, M.J, Van Rietschoten, J, Giralt, E, El Ayeb, M, Rochat, H, Sabatier, J.M, Darbon, H, Mabrouk, K. | Deposit date: | 2003-07-15 | Release date: | 2005-05-03 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Lebetin peptides, a new class of potent aggregation inhibitors To be Published
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1EHX
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![BU of 1ehx by Molmil](/molmil-images/mine/1ehx) | NMR SOLUTION STRUCTURE OF THE LAST UNKNOWN MODULE OF THE CELLULOSOMAL SCAFFOLDIN PROTEIN CIPC OF CLOSTRIDUM CELLULOLYTICUM | Descriptor: | SCAFFOLDIN PROTEIN | Authors: | Mosbah, A, Belaich, A, Bornet, O, Belaich, J.P, Henrissat, B, Darbon, H. | Deposit date: | 2000-02-23 | Release date: | 2000-11-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of the module X2 1 of unknown function of the cellulosomal scaffolding protein CipC of Clostridium cellulolyticum. J.Mol.Biol., 304, 2000
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1JMN
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![BU of 1jmn by Molmil](/molmil-images/mine/1jmn) | Solution Structure of the Viscotoxin A2 | Descriptor: | viscotoxin A2 | Authors: | Mosbah, A, Coulon, A, Bernard, C, Urech, K, Rouge, P, Darbon, H. | Deposit date: | 2001-07-19 | Release date: | 2003-06-24 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution Structure of the Viscotoxin A2 TO BE PUBLISHED
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1Y2P
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![BU of 1y2p by Molmil](/molmil-images/mine/1y2p) | |
2LCB
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![BU of 2lcb by Molmil](/molmil-images/mine/2lcb) | Solution Structure of a Minor and Transiently Formed State of a T4 Lysozyme Mutant | Descriptor: | Lysozyme | Authors: | Bouvignies, G, Vallurupalli, P, Hansen, D, Correia, B, Lange, O, Bah, A, Vernon, R.M, Dahlquist, F.W, Baker, D, Kay, L.E. | Deposit date: | 2011-04-26 | Release date: | 2011-08-17 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of a minor and transiently formed state of a T4 lysozyme mutant. Nature, 477, 2011
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2LC9
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![BU of 2lc9 by Molmil](/molmil-images/mine/2lc9) | Solution Structure of a Minor and Transiently Formed State of a T4 Lysozyme Mutant | Descriptor: | Lysozyme | Authors: | Bouvignies, G, Vallurupalli, P, Hansen, D, Correia, B, Lange, O, Bah, A, Vernon, R.M, Dahlquist, F.W, Baker, D, Kay, L.E. | Deposit date: | 2011-04-26 | Release date: | 2011-08-17 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution structure of a minor and transiently formed state of a T4 lysozyme mutant. Nature, 477, 2011
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3JZ1
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![BU of 3jz1 by Molmil](/molmil-images/mine/3jz1) | Crystal structure of human thrombin mutant N143P in E:Na+ form | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, NITRATE ION, ... | Authors: | Niu, W, Chen, Z, Bush-Pelc, L.A, Bah, A, Gandhi, P.S, Di Cera, E. | Deposit date: | 2009-09-22 | Release date: | 2009-10-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Mutant N143P reveals how Na+ activates thrombin J.Biol.Chem., 284, 2009
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3JZ2
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![BU of 3jz2 by Molmil](/molmil-images/mine/3jz2) | Crystal structure of human thrombin mutant N143P in E* form | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Thrombin heavy chain, ... | Authors: | Niu, W, Chen, Z, Bush-Pelc, L.A, Bah, A, Gandhi, P.S, Di Cera, E. | Deposit date: | 2009-09-22 | Release date: | 2009-10-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Mutant N143P reveals how Na+ activates thrombin J.Biol.Chem., 284, 2009
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3E6P
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![BU of 3e6p by Molmil](/molmil-images/mine/3e6p) | Crystal structure of human meizothrombin desF1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-PHENYLALANYL-N-[(1S)-4-{[(Z)-AMINO(IMINO)METHYL]AMINO}-1-(CHLOROACETYL)BUTYL]-L-PROLINAMIDE, Prothrombin, ... | Authors: | Papaconstantinou, M.E, Gandhi, P, Chen, Z, Bah, A, Di Cera, E. | Deposit date: | 2008-08-15 | Release date: | 2008-11-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Na(+) binding to meizothrombin desF1. Cell.Mol.Life Sci., 65, 2008
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3R3G
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![BU of 3r3g by Molmil](/molmil-images/mine/3r3g) | Structure of human thrombin with residues 145-150 of murine thrombin. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Thrombin Heavy Chain, ... | Authors: | Pozzi, N, Chen, R, Chen, Z, Bah, A, Di Cera, E. | Deposit date: | 2011-03-15 | Release date: | 2011-05-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Rigidification of the autolysis loop enhances Na(+) binding to thrombin. Biophys.Chem., 159, 2011
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3BEF
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![BU of 3bef by Molmil](/molmil-images/mine/3bef) | Crystal structure of thrombin bound to the extracellular fragment of PAR1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Proteinase-activated receptor 1, Prothrombin | Authors: | Gandhi, P.S, Bah, A, Chen, Z, Mathews, F.S, Di Cera, E. | Deposit date: | 2007-11-17 | Release date: | 2008-01-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural identification of the pathway of long-range communication in an allosteric enzyme. Proc.Natl.Acad.Sci.Usa, 105, 2008
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8P73
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![BU of 8p73 by Molmil](/molmil-images/mine/8p73) | Cryo-EM structure of CAK in complex with inhibitor ICEC0829 | Descriptor: | (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidine-3,4-diol, (3S,4S)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidine-3,4-diol, CDK-activating kinase assembly factor MAT1, ... | Authors: | Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J. | Deposit date: | 2023-05-30 | Release date: | 2024-03-20 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2 Å) | Cite: | High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nat Commun, 15, 2024
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8P6Y
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![BU of 8p6y by Molmil](/molmil-images/mine/8p6y) | Cryo-EM structure of CAK in complex with nucleotide analogue ATPgS | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J. | Deposit date: | 2023-05-30 | Release date: | 2023-08-30 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (1.9 Å) | Cite: | High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nat Commun, 15, 2024
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8P6V
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![BU of 8p6v by Molmil](/molmil-images/mine/8p6v) | Cryo-EM structure of CAK in complex with inhibitor ICEC0942 | Descriptor: | (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ... | Authors: | Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J. | Deposit date: | 2023-05-30 | Release date: | 2023-08-30 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (1.9 Å) | Cite: | High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nat Commun, 15, 2024
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8ORM
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![BU of 8orm by Molmil](/molmil-images/mine/8orm) | Cryo-EM structure of CAK-THZ1 | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J. | Deposit date: | 2023-04-14 | Release date: | 2023-08-30 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (1.9 Å) | Cite: | High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nat Commun, 15, 2024
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