3GIC

Structure of thrombin mutant delta(146-149e) in the free form

Summary for 3GIC

• Entry DOI: 10.2210/pdb3gic/pdb
• Descriptor: Thrombin light chain, Thrombin heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: serine protease, chymotrypsin fold, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, disulfide bond, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, zymogen
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 33109.89

Authors

Bah, A.,Carrell, C.J.,Chen, Z.,Gandhi, P.S.,Di Cera, E. (deposition date: 2009-03-05, release date: 2009-06-02, Last modification date: 2023-09-06)

• Primary citation: Bah, A.,Carrell, C.J.,Chen, Z.,Gandhi, P.S.,Di Cera, E.; Stabilization of the E* form turns thrombin into an anticoagulant.; J.Biol.Chem., 284:20034-20040, 2009; PubMed: 19473969; DOI: 10.1074/jbc.M109.012344

Experimental method

X-RAY DIFFRACTION (1.55 Å)