3NPS

Crystal structure of membrane-type serine protease 1 (MT-SP1) in complex with the Fab Inhibitor S4

Summary for 3NPS

Entry DOI	10.2210/pdb3nps/pdb
Descriptor	Suppressor of tumorigenicity 14 protein, S4 FAB HEAVY CHAIN, S4 FAB LIGHT CHAIN, ... (7 entities in total)
Functional Keywords	hydrolase, antibody-protease complex, protein-protein complex, enzyme-inhibitor complex, disease mutation, glycoprotein, membrane, serine protease, signal-anchor, transmembrane, hydrolase - immune system complex, hydrolase-immune system complex, hydrolase/immune system
Biological source	Homo sapiens (human) More
Cellular location	Membrane ; Single-pass type II membrane protein : Q9Y5Y6
Total number of polymer chains	3
Total formula weight	74083.93
Authors	Baharuddin, A. (deposition date: 2010-06-29, release date: 2011-07-06, Last modification date: 2023-09-06)
Primary citation	Schneider, E.L.,Lee, M.S.,Baharuddin, A.,Goetz, D.H.,Farady, C.J.,Ward, M.,Wang, C.I.,Craik, C.S. A reverse binding motif that contributes to specific protease inhibition by antibodies. J.Mol.Biol., 415:699-715, 2012 Cited by PubMed: 22154938 DOI: 10.1016/j.jmb.2011.11.036 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation