3NPS
Crystal structure of membrane-type serine protease 1 (MT-SP1) in complex with the Fab Inhibitor S4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Suppressor of tumorigenicity 14 protein | polymer | 241 | 26447.7 | 1 | UniProt (Q9Y5Y6) Pfam (PF00089) | Homo sapiens (human) | Serine protease 14, Matriptase, Membrane-type serine protease 1, MT-SP1, Prostamin, Serine protease TADG-15, Tumor-associated differentially-expressed gene 15 protein |
| 2 | B (B) | S4 FAB HEAVY CHAIN | polymer | 226 | 24134.1 | 1 | Homo sapiens (human) | ||
| 3 | C (C) | S4 FAB LIGHT CHAIN | polymer | 211 | 22731.1 | 1 | Homo sapiens (human) | ||
| 4 | D, E, F, G, H... (A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 5 | J, K, P, Q, S (A, B, C) | SODIUM ION | non-polymer | 23.0 | 5 | Chemie (NA) | |||
| 6 | L (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | T, U, V (A, B, C) | water | water | 18.0 | 676 | Chemie (HOH) |
Sequence modifications
A: 16 - 244 (UniProt: Q9Y5Y6)
| PDB | External Database | Details |
|---|---|---|
| Ser 122 | Cys 731 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 73312.8 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 771.1 | |
| All* | Total formula weight | 74083.9 |
