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PDB: 57 件
2PZD
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BU of 2pzd by Molmil
Crystal Structure of the HtrA2/Omi PDZ Domain Bound to a Phage-Derived Ligand (WTMFWV)
分子名称: 1,2-ETHANEDIOL, Serine protease HTRA2
著者Appleton, B.A, Wiesmann, C.
登録日2007-05-17
公開日2007-08-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain.
Protein Sci., 16, 2007
2AQ5
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BU of 2aq5 by Molmil
Crystal Structure of Murine Coronin-1
分子名称: Coronin-1A
著者Appleton, B.A, Wu, P, Wiesmann, C.
登録日2005-08-17
公開日2005-12-06
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes.
Structure, 14, 2006
3QTI
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BU of 3qti by Molmil
c-Met Kinase in Complex with NVP-BVU972
分子名称: 6-{[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline, CHLORIDE ION, GLYCEROL, ...
著者Appleton, B.A.
登録日2011-02-22
公開日2011-07-06
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients.
Cancer Res., 71, 2011
5D9K
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BU of 5d9k by Molmil
Rsk2 N-terminal Kinase in Complex with BI-D1870
分子名称: (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, GLYCEROL, Ribosomal protein S6 kinase alpha-3
著者Appleton, B.A.
登録日2015-08-18
公開日2015-09-02
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Discovery of Potent and Selective RSK Inhibitors as Biological Probes.
J.Med.Chem., 58, 2015
5D9L
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BU of 5d9l by Molmil
Rsk2 N-terminal Kinase in Complex with bis-phenol pyrazole
分子名称: 4,4'-(1H-pyrazole-3,4-diyl)diphenol, GLYCEROL, Ribosomal protein S6 kinase alpha-3
著者Appleton, B.A.
登録日2015-08-18
公開日2015-09-02
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Discovery of Potent and Selective RSK Inhibitors as Biological Probes.
J.Med.Chem., 58, 2015
2QQO
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BU of 2qqo by Molmil
Crystal Structure of the a2b1b2 Domains from Human Neuropilin-2
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ...
著者Appleton, B.A, Wiesmann, C.
登録日2007-07-26
公開日2007-11-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQK
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BU of 2qqk by Molmil
Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Heavy Chain, Antibody Light Chain, ...
著者Appleton, B.A, Wiesmann, C.
登録日2007-07-26
公開日2007-11-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQI
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BU of 2qqi by Molmil
Crystal Structure of the b1b2 Domains from Human Neuropilin-1
分子名称: GLYCEROL, Neuropilin-1
著者Appleton, B.A, Desmarais, W, Wiesmann, C.
登録日2007-07-26
公開日2007-11-20
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQL
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BU of 2qql by Molmil
Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab
分子名称: Antibody Heavy Chain, Antibody Light Chain, Neuropilin-2
著者Appleton, B.A, Wiesmann, C.
登録日2007-07-26
公開日2007-11-20
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQJ
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BU of 2qqj by Molmil
Crystal Structure of the b1b2 Domains from Human Neuropilin-2
分子名称: GLYCEROL, Neuropilin-2
著者Appleton, B.A, Wiesmann, C.
登録日2007-07-26
公開日2007-11-20
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQM
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BU of 2qqm by Molmil
Crystal Structure of the a2b1b2 Domains from Human Neuropilin-1
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Appleton, B.A, Wiesmann, C.
登録日2007-07-26
公開日2007-11-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQN
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BU of 2qqn by Molmil
Neuropilin-1 b1 Domain in Complex with a VEGF-Blocking Fab
分子名称: 1,2-ETHANEDIOL, Antibody heavy chain, Antibody light chain, ...
著者Appleton, B.A, Wiesmann, C.
登録日2007-07-26
公開日2007-11-20
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2P3W
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BU of 2p3w by Molmil
Crystal Structure of the HtrA3 PDZ Domain Bound to a Phage-Derived Ligand (FGRWV)
分子名称: Probable serine protease HTRA3
著者Appleton, B.A, Wiesmann, C.
登録日2007-03-09
公開日2007-11-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3.
Protein Sci., 16, 2007
5CT7
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BU of 5ct7 by Molmil
BRAF in Complex with RAF265
分子名称: 1-methyl-5-({2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine, Serine/threonine-protein kinase B-raf
著者Appleton, B.A.
登録日2015-07-23
公開日2015-09-09
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.17 Å)
主引用文献Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma.
Acs Med.Chem.Lett., 6, 2015
3CBX
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BU of 3cbx by Molmil
The Dvl2 PDZ Domain in Complex with the C1 Inhibitory Peptide
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Dishevelled-2
著者Appleton, B.A, Wiesmann, C.
登録日2008-02-23
公開日2009-03-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nat.Chem.Biol., 5, 2009
3CBY
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BU of 3cby by Molmil
The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide
分子名称: 1,2-ETHANEDIOL, Dishevelled-2
著者Appleton, B.A, Wiesmann, C.
登録日2008-02-23
公開日2009-03-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nat.Chem.Biol., 5, 2009
3CBZ
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BU of 3cbz by Molmil
The Dvl2 PDZ Domain in Complex with the N2 Inhibitory Peptide
分子名称: 1,2-ETHANEDIOL, Dishevelled-2, PHOSPHATE ION
著者Appleton, B.A, Wiesmann, C.
登録日2008-02-23
公開日2009-03-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nat.Chem.Biol., 5, 2009
3CC0
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BU of 3cc0 by Molmil
The Dvl2 PDZ Domain in Complex with the N3 Inhibitory Peptide
分子名称: Dishevelled-2
著者Appleton, B.A, Wiesmann, C.
登録日2008-02-23
公開日2009-03-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nat.Chem.Biol., 5, 2009
3B9V
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BU of 3b9v by Molmil
Crystal Structure of an Autonomous VH Domain
分子名称: heavy chain variable domain
著者Appleton, B.A, Barthelemy, P.A, Wiesmann, C.
登録日2007-11-06
公開日2007-11-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Comprehensive Analysis of the Factors Contributing to the Stability and Solubility of Autonomous Human VH Domains.
J.Biol.Chem., 283, 2008
7LT6
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BU of 7lt6 by Molmil
Structure of Partial Beta-Hairpin LIR from FNIP2 Bound to GABARAP
分子名称: Folliculin-interacting protein 2,Gamma-aminobutyric acid receptor-associated protein
著者Appleton, B.A.
登録日2021-02-18
公開日2021-10-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis.
Sci Adv, 7, 2021
7LSW
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BU of 7lsw by Molmil
Structure of Full Beta-Hairpin LIR from FNIP2 Bound to GABARAP
分子名称: Folliculin-interacting protein 2,Gamma-aminobutyric acid receptor-associated protein, SULFATE ION
著者Appleton, B.A.
登録日2021-02-18
公開日2021-10-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis.
Sci Adv, 7, 2021
4Q2O
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BU of 4q2o by Molmil
PDLIM4 PDZ in Complex with a Phage-Derived Peptide
分子名称: PDZ and LIM domain protein 4
著者Appleton, B.A, Wiesmann, C.
登録日2014-04-09
公開日2014-09-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A structural portrait of the PDZ domain family.
J.Mol.Biol., 426, 2014
4Q2Q
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BU of 4q2q by Molmil
ZO1 PDZ3 in Complex with a Phage-Derived Peptide
分子名称: Tight junction protein ZO-1
著者Appleton, B.A, Wiesmann, C.
登録日2014-04-09
公開日2014-09-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献A structural portrait of the PDZ domain family.
J.Mol.Biol., 426, 2014
4Q2P
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BU of 4q2p by Molmil
NHERF3 PDZ2 in Complex with a Phage-Derived Peptide
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Na(+)/H(+) exchange regulatory cofactor NHE-RF3
著者Appleton, B.A, Wiesmann, C.
登録日2014-04-09
公開日2014-09-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献A structural portrait of the PDZ domain family.
J.Mol.Biol., 426, 2014
4Q2N
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BU of 4q2n by Molmil
INADL PDZ3 in Complex with a Phage-Derived Peptide
分子名称: 1,2-ETHANEDIOL, InaD-like protein
著者Appleton, B.A, Wiesmann, C.
登録日2014-04-09
公開日2014-09-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A structural portrait of the PDZ domain family.
J.Mol.Biol., 426, 2014

 

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