3QTI

c-Met Kinase in Complex with NVP-BVU972

Summary for 3QTI

Entry DOI	10.2210/pdb3qti/pdb
Descriptor	Hepatocyte growth factor receptor, 6-{[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	kinase, transerase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P08581
Total number of polymer chains	2
Total formula weight	71651.79
Authors	Appleton, B.A. (deposition date: 2011-02-22, release date: 2011-07-06, Last modification date: 2024-02-21)
Primary citation	Tiedt, R.,Degenkolbe, E.,Furet, P.,Appleton, B.A.,Wagner, S.,Schoepfer, J.,Buck, E.,Ruddy, D.A.,Monahan, J.E.,Jones, M.D.,Blank, J.,Haasen, D.,Drueckes, P.,Wartmann, M.,McCarthy, C.,Sellers, W.R.,Hofmann, F. A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients. Cancer Res., 71:5255-5264, 2011 Cited by PubMed: 21697284 DOI: 10.1158/0008-5472.CAN-10-4433 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation