3QTI
c-Met Kinase in Complex with NVP-BVU972
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Hepatocyte growth factor receptor | polymer | 314 | 35404.0 | 2 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (human) | HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met |
2 | A, B | 6-{[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline | non-polymer | 340.4 | 2 | Chemie (3QT) | |||
3 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
4 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | water | water | 18.0 | 395 | Chemie (HOH) |
Sequence modifications
A, B: 1050 - 1360 (UniProt: P08581)
PDB | External Database | Details |
---|---|---|
Gly 1047 | - | expression tag |
Pro 1048 | - | expression tag |
Gly 1049 | - | expression tag |
Phe 1194 | Tyr 1194 | engineered mutation |
Phe 1234 | Tyr 1234 | engineered mutation |
Asp 1235 | Tyr 1235 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 70808.0 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 843.8 | |
All* | Total formula weight | 71651.8 |