3QTI
c-Met Kinase in Complex with NVP-BVU972
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hepatocyte growth factor receptor | polymer | 314 | 35404.0 | 2 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met |
| 2 | C, E (A, B) | 6-{[6-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline | non-polymer | 340.4 | 2 | Chemie (3QT) | |||
| 3 | D, F (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | G (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 395 | Chemie (HOH) |
Sequence modifications
A, B: 1050 - 1360 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Gly 1047 | - | expression tag |
| Pro 1048 | - | expression tag |
| Gly 1049 | - | expression tag |
| Phe 1194 | Tyr 1194 | engineered mutation |
| Phe 1234 | Tyr 1234 | engineered mutation |
| Asp 1235 | Tyr 1235 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70808.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 843.8 | |
| All* | Total formula weight | 71651.8 |
