8ZQ3
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6LE5
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![BU of 6le5 by Molmil](/molmil-images/mine/6le5) | Crystal structure of the mitochondrial calcium uptake 1 and 2 heterodimer (MICU1-MICU2 heterodimer) in an apo state | 分子名称: | Calcium uptake protein 1, mitochondrial, Calcium uptake protein 2 | 著者 | Park, J, Lee, Y, Park, T, Kang, J.Y, Jin, M, Yang, J, Eom, S.H. | 登録日 | 2019-11-24 | 公開日 | 2020-03-04 | 最終更新日 | 2020-03-25 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of the MICU1-MICU2 heterodimer provides insights into the gatekeeping threshold shift. Iucrj, 7, 2020
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8XCG
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4NTJ
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![BU of 4ntj by Molmil](/molmil-images/mine/4ntj) | Structure of the human P2Y12 receptor in complex with an antithrombotic drug | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, P2Y purinoceptor 12,Soluble cytochrome b562,P2Y purinoceptor 12, ... | 著者 | Zhang, K, Zhang, J, Gao, Z.-G, Zhang, D, Zhu, L, Han, G.W, Moss, S.M, Paoletta, S, Kiselev, E, Lu, W, Fenalti, G, Zhang, W, Muller, C.E, Yang, H, Jiang, H, Cherezov, V, Katritch, V, Jacobson, K.A, Stevens, R.C, Wu, B, Zhao, Q, GPCR Network (GPCR) | 登録日 | 2013-12-02 | 公開日 | 2014-03-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Structure of the human P2Y12 receptor in complex with an antithrombotic drug Nature, 509, 2014
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8XCI
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8XCK
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8XCJ
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5HBY
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![BU of 5hby by Molmil](/molmil-images/mine/5hby) | RNA primer-template complex with 2-methylimidazole-activated monomer analogue-3 binding sites | 分子名称: | MAGNESIUM ION, RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*C)-3'), [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-(3-methyl-1~{H}-pyrazol-4-yl)phosphinic acid | 著者 | Zhang, W, Tam, C.P, Wang, J, Szostak, J.W. | 登録日 | 2016-01-03 | 公開日 | 2016-12-07 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | Unusual Base-Pairing Interactions in Monomer-Template Complexes. ACS Cent Sci, 2, 2016
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6DVR
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![BU of 6dvr by Molmil](/molmil-images/mine/6dvr) | Crystal structure of human CARM1 with (R)-SKI-72 | 分子名称: | (2R,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-methoxyphenyl)ethyl]hexanamide (non-preferred name), 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, Histone-arginine methyltransferase CARM1, ... | 著者 | Dong, A, Zeng, H, Hutchinson, A, Seitova, A, Luo, M, Cai, X.C, Ke, W, Wang, J, Shi, C, Zheng, W, Lee, J.P, Ibanez, G, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | 登録日 | 2018-06-25 | 公開日 | 2018-07-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Crystal structure of human CARM1 with (R)-SKI-72 to be published
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6LTU
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![BU of 6ltu by Molmil](/molmil-images/mine/6ltu) | Crystal structure of Cas12i2 ternary complex with double Mg2+ bound in catalytic pocket | 分子名称: | 1,2-ETHANEDIOL, Cas12i2, DNA (35-MER), ... | 著者 | Huang, X, Sun, W, Cheng, Z, Chen, M, Li, X, Wang, J, Sheng, G, Gong, W, Wang, Y. | 登録日 | 2020-01-23 | 公開日 | 2020-10-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2. Nat Commun, 11, 2020
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1V11
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![BU of 1v11 by Molmil](/molmil-images/mine/1v11) | CROSSTALK BETWEEN COFACTOR BINDING AND THE PHOSPHORYLATION LOOP CONFORMATION IN THE BCKD MACHINE | 分子名称: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, BENZAMIDINE, ... | 著者 | Li, J, Wynn, R.M, Machius, M, Chuang, J.L, Karthikeyan, S, Tomchick, D.R, Chuang, D.T. | 登録日 | 2004-04-05 | 公開日 | 2004-06-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Cross-Talk between Thiamin Diphosphate Binding and Phosphorylation Loop Conformation in Human Branched-Chain {Alpha}-Keto Acid Decarboxylase/Dehydrogenase J.Biol.Chem., 279, 2004
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1V1M
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![BU of 1v1m by Molmil](/molmil-images/mine/1v1m) | CROSSTALK BETWEEN COFACTOR BINDING AND THE PHOSPHORYLATION LOOP CONFORMATION IN THE BCKD MACHINE | 分子名称: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, BENZAMIDINE, ... | 著者 | Li, J, Wynn, R.M, Machius, M, Chuang, J.L, Karthikeyan, S, Tomchick, D.R, Chuang, D.T. | 登録日 | 2004-04-20 | 公開日 | 2004-06-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Cross-Talk between Thiamin Diphosphate Binding and Phosphorylation Loop Conformation in Human Branched-Chain Alpha-Keto Acid Decarboxylase/Dehydrogenase. J.Biol.Chem., 279, 2004
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1V1R
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![BU of 1v1r by Molmil](/molmil-images/mine/1v1r) | CROSSTALK BETWEEN COFACTOR BINDING AND THE PHOSPHORYLATION LOOP CONFORMATION IN THE BCKD MACHINE | 分子名称: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, CHLORIDE ION, ... | 著者 | Li, J, Wynn, R.M, Machius, M, Chuang, J.L, Karthikeyan, S, Tomchick, D.R, Chuang, D.T. | 登録日 | 2004-04-22 | 公開日 | 2004-06-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Cross-Talk between Thiamin Diphosphate Binding and Phosphorylation Loop Conformation in Human Branched-Chain {Alpha}-Keto Acid Decarboxylase/Dehydrogenase J.Biol.Chem., 279, 2004
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6LDL
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![BU of 6ldl by Molmil](/molmil-images/mine/6ldl) | Crystal structure of CYP116B46-N(20-445) from Tepidiphilus thermophilus in complex with HEME | 分子名称: | BICINE, Cytochrome P450, GLYCEROL, ... | 著者 | Zhang, L.L, Xie, Z.Z, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2019-11-21 | 公開日 | 2020-10-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Structural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase. Nat Commun, 11, 2020
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8WGQ
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![BU of 8wgq by Molmil](/molmil-images/mine/8wgq) | The Crystal Structure of L-asparaginase from Biortus. | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, L-asparaginase | 著者 | Wang, F, Cheng, W, Lv, Z, Ju, C, Wang, J. | 登録日 | 2023-09-22 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | The Crystal Structure of L-asparaginase from Biortus. To Be Published
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8X70
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![BU of 8x70 by Molmil](/molmil-images/mine/8x70) | The Crystal Structure of IFI16 from Biortus. | 分子名称: | 1,2-ETHANEDIOL, BROMIDE ION, Gamma-interferon-inducible protein 16, ... | 著者 | Wang, F, Cheng, W, Lv, Z, Meng, Q, Wang, J. | 登録日 | 2023-11-22 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The Crystal Structure of IFI16 from Biortus. To Be Published
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5H7O
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![BU of 5h7o by Molmil](/molmil-images/mine/5h7o) | Crystal structure of DJ-101 in complex with tubulin protein | 分子名称: | 2-(1H-indol-4-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Arnst, K, Wang, Y, Hwang, D.-J, Xue, Y, Costello, T, Hamilton, D, Chen, Q, Yang, J, Park, F, Dalton, J.T, Miller, D.D, Li, W. | 登録日 | 2016-11-20 | 公開日 | 2017-12-13 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance. Cancer Res., 78, 2018
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5VVT
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![BU of 5vvt by Molmil](/molmil-images/mine/5vvt) | Structural Investigations of the Substrate Specificity of Human O-GlcNAcase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ELK1 peptide, Protein O-GlcNAcase | 著者 | Li, B, Jiang, J, Li, H, Hu, C.-W. | 登録日 | 2017-05-20 | 公開日 | 2017-09-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase. Nat Commun, 8, 2017
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5VVV
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![BU of 5vvv by Molmil](/molmil-images/mine/5vvv) | Structural Investigations of the Substrate Specificity of Human O-GlcNAcase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein O-GlcNAcase, a-crystallin B | 著者 | Li, B, Jiang, J, Li, H, Hu, C.-W. | 登録日 | 2017-05-20 | 公開日 | 2017-09-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase. Nat Commun, 8, 2017
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6L62
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![BU of 6l62 by Molmil](/molmil-images/mine/6l62) | Neutralization mechanism of a monoclonal antibody targeting a porcine circovirus type 2 Cap protein conformational epitope | 分子名称: | Capsid protein, Heavy chain of Fab fragment, Light chain of Fab fragment | 著者 | Sun, Z, Huang, L, Xia, D, Wei, Y, Sun, E, Zhu, H, Bian, H, Wu, H, Feng, L, Wang, J, Liu, C. | 登録日 | 2019-10-25 | 公開日 | 2020-02-12 | 最終更新日 | 2020-04-29 | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | 主引用文献 | Neutralization Mechanism of a Monoclonal Antibody Targeting a Porcine Circovirus Type 2 Cap Protein Conformational Epitope. J.Virol., 94, 2020
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6E59
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![BU of 6e59 by Molmil](/molmil-images/mine/6e59) | Crystal structure of the human NK1 tachykinin receptor | 分子名称: | 1-(4-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1H-1,2,3-triazol-5-yl)-N,N-dimethylmethanamine, Substance-P receptor, GlgA glycogen synthase, ... | 著者 | Yin, J, Clark, L, Chapman, K, Shao, Z, Borek, D, Xu, Q, Wang, J, Rosenbaum, D.M. | 登録日 | 2018-07-19 | 公開日 | 2018-12-12 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Crystal structure of the human NK1tachykinin receptor. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6DF6
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![BU of 6df6 by Molmil](/molmil-images/mine/6df6) | Crystal structure of estrogen receptor alpha in complex with receptor degrader 16ab | 分子名称: | (8R)-8-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-1,8-dihydro-2H-[1]benzopyrano[4,3-d][1]benzoxepine-5,11-diol, Estrogen receptor, GLYCEROL | 著者 | Kiefer, J.R, Vinogradova, M, Liang, J, Zhang, B, Ortwine, D.F, Nettles, K.W, Nwachukwu, J.C. | 登録日 | 2018-05-14 | 公開日 | 2019-02-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Bioorg. Med. Chem. Lett., 29, 2019
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6DFN
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![BU of 6dfn by Molmil](/molmil-images/mine/6dfn) | Crystal structure of estrogen receptor alpha in complex with receptor degrader 16aa | 分子名称: | (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, (8S)-8-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-1,8-dihydro-2H-[1]benzopyrano[4,3-d][1]benzoxepine-5,11-diol, Estrogen receptor, ... | 著者 | Kiefer, J.R, Vinogradova, M, Liang, J, Zhang, B, Ortwine, D.F, Nettles, K.W, Nwachukwu, J.C. | 登録日 | 2018-05-15 | 公開日 | 2019-02-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Bioorg. Med. Chem. Lett., 29, 2019
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8WGF
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![BU of 8wgf by Molmil](/molmil-images/mine/8wgf) | The Crystal Structure of JNK3 from Biortus. | 分子名称: | MAGNESIUM ION, Mitogen-activated protein kinase 10, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Wang, F, Cheng, W, Lv, Z, Ju, C, Wang, J. | 登録日 | 2023-09-21 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | The Crystal Structure of JNK3 from Biortus. To Be Published
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8XOX
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![BU of 8xox by Molmil](/molmil-images/mine/8xox) | The Crystal Structure of FAK2 from Biortus. | 分子名称: | 1,2-ETHANEDIOL, N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide, Protein-tyrosine kinase 2-beta | 著者 | Wang, F, Cheng, W, Lv, Z, Ju, C, Wang, J. | 登録日 | 2024-01-02 | 公開日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The Crystal Structure of FAK2 from Biortus. To Be Published
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