5MZF
 
 | | Crystal structure of dog MTH1 protein | | 分子名称: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | | 著者 | Narwal, M, Jemth, A.-S, Helleday, T, Stenmark, P. | | 登録日 | 2017-01-31 | | 公開日 | 2018-01-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Biochemistry, 57, 2018
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6WD8
 | | Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-A) | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | 著者 | Loveland, A.B, Demo, G, Korostelev, A.A. | | 登録日 | 2020-03-31 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading.
Nature, 584, 2020
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6UR8
 | | CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chimera of soluble cytochrome b562 (BRIL) and neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit beta-2, ... | | 著者 | Alvarez, F.J.D, Mukherjee, S, Han, S, Ammirati, M, Kossiakoff, A.A. | | 登録日 | 2019-10-22 | | 公開日 | 2020-04-29 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | | 主引用文献 | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Nat Commun, 11, 2020
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8QUQ
 | | Crystal structure of Ompk36 GD at 3500 eV based on spherical harmonics absorption corrections | | 分子名称: | OmpK36, SULFATE ION | | 著者 | Duman, R, Wagner, A, Beis, K, Wong, J. | | 登録日 | 2023-10-16 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Ray-tracing analytical absorption correction for X-ray crystallography based on tomographic reconstructions.
J.Appl.Crystallogr., 57, 2024
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6WEX
 | | Crystal Structure of Broadly Neutralizing Antibody 3I14-D93N Mutant Bound to the Influenza A H6 Hemagglutinin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, Hemagglutinin HA2 chain, ... | | 著者 | Harshbarger, W.D, Lockbaum, G.J, Deming, D.T, Attatippaholkun, N, Schiffer, C.A, Marasco, W.A. | | 登録日 | 2020-04-03 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | | 主引用文献 | Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses.
Nat Commun, 12, 2021
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5FWS
 | | Wnt modulator Kremen crystal form I at 1.90A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, KREMEN PROTEIN 1, ... | | 著者 | Zebisch, M, Jackson, V.A, Jones, E.Y. | | 登録日 | 2016-02-21 | | 公開日 | 2016-07-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight Into Ternary Complex Formation with Lrp6 and Dickkopf
Structure, 24, 2016
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6H46
 | | Human KRAS in complex with darpin K13 | | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ... | | 著者 | Debreczeni, J.E, Bery, N, Legg, S, Breed, J, Embrey, K, Stubbs, C, Kolasinska-Zwierz, P, Barrett, N, Marwood, R, Watson, J, Tart, J, Overman, R, Miller, A, Phillips, C, Minter, R, Rabbitts, T.H. | | 登録日 | 2018-07-20 | | 公開日 | 2019-04-24 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Nat Commun, 10, 2019
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8ODU
 | | Chaetomium thermophilum Get1/Get2 heterotetramer in complex with a Get3 dimer (amphipol) | | 分子名称: | ATPase GET3, Protein GET2,Protein GET1, ZINC ION | | 著者 | McDowell, M.A, Wild, K, Sinning, I. | | 登録日 | 2023-03-09 | | 公開日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (5 Å) | | 主引用文献 | The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
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4WXK
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5CPI
 | | Nucleosome containing unmethylated Sat2R DNA | | 分子名称: | DNA (146-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Osakabe, A, Arimura, Y, Adachi, F, Maehara, K, Ohkawa, Y, Kurumizaka, H. | | 登録日 | 2015-07-21 | | 公開日 | 2015-10-28 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.902 Å) | | 主引用文献 | Influence of DNA methylation on positioning and DNA flexibility of nucleosomes with pericentric satellite DNA.
Open Biology, 5, 2015
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6OKG
 | | Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabF, and C16-crypto Acyl Carrier Protein, AcpP | | 分子名称: | 3-oxoacyl-[acyl-carrier-protein] synthase 2, Acyl carrier protein, N-[2-(hexadecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ... | | 著者 | Mindrebo, J.T, Kim, W.E, Bartholow, T.G, Chen, A, Davis, T.D, La Clair, J, Burkart, M.D, Noel, J.P. | | 登録日 | 2019-04-12 | | 公開日 | 2020-04-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Gating mechanism of elongating beta-ketoacyl-ACP synthases.
Nat Commun, 11, 2020
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4OOC
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6SML
 | | Structure of the RagAB peptide importer in the 'open-open' state | | 分子名称: | (1R,4S,6R)-6-({[2-(ACETYLAMINO)-2-DEOXY-ALPHA-D-GLUCOPYRANOSYL]OXY}METHYL)-4-HYDROXY-1-{[(15-METHYLHEXADECANOYL)OXY]METHYL}-4-OXIDO-7-OXO-3,5-DIOXA-8-AZA-4-PHOSPHAHEPTACOS-1-YL 15-METHYLHEXADECANOATE, GLY-THR-GLY-GLY-SER-THR-GLY-THR-THR-SER-ALA-GLY, Lipoprotein RagB, ... | | 著者 | White, J.B.R, Ranson, N.A, van den Berg, B. | | 登録日 | 2019-08-22 | | 公開日 | 2020-05-20 | | 最終更新日 | 2020-08-05 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural and functional insights into oligopeptide acquisition by the RagAB transporter from Porphyromonas gingivalis.
Nat Microbiol, 5, 2020
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4WY2
 | | Crystal structure of universal stress protein E from Proteus mirabilis in complex with UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-glucosamine | | 分子名称: | CHLORIDE ION, GLYCEROL, SULFATE ION, ... | | 著者 | Shumilin, I.A, Shabalin, I.G, Handing, K.B, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2014-11-15 | | 公開日 | 2014-11-26 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of universal stress protein E from Proteus mirabilis incomplex withUDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetyl-alpha-glucosamine
to be published
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8ODV
 | | Chaetomium thermophilum Get1/Get2 heterotetramer in complex with a Get3 dimer (nanodisc) | | 分子名称: | ATPase GET3, Protein GET2,Protein GET1, ZINC ION | | 著者 | McDowell, M.A, Wild, K, Sinning, I. | | 登録日 | 2023-03-09 | | 公開日 | 2023-11-29 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
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1QX7
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7UL6
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8GBV
 | | Crystal structure of PC39-17A, an anti-HIV broadly neutralizing antibody | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, PC39-17A Fab heavy chain, ... | | 著者 | Murrell, S, Omorodion, O, Wilson, I.A. | | 登録日 | 2023-02-28 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-07-12 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies.
Plos Pathog., 19, 2023
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4X8M
 | | Crystal structure of E. coli Adenylate kinase Y171W mutant | | 分子名称: | Adenylate kinase | | 著者 | Sauer-Eriksson, A.E, Kovermann, M, Aden, J, Grundstrom, C, Wolf-Watz, M, Sauer, U.H. | | 登録日 | 2014-12-10 | | 公開日 | 2015-07-15 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis for catalytically restrictive dynamics of a high-energy enzyme state.
Nat Commun, 6, 2015
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5CV4
 | | Crystal structure of Staphylococcal nuclease variant Delta+PHS V23D/V66H at cryogenic temperature | | 分子名称: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | | 著者 | Theodoru, A, Robinson, A.C, Schlessman, J.L, Garcia-Moreno E, B. | | 登録日 | 2015-07-25 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of Staphylococcal nuclease variant Delta+PHS V23D/V66H at cryogenic temperature
To be Published
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5LZV
 | | Structure of the mammalian ribosomal termination complex with accommodated eRF1(AAQ) and ABCE1. | | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | | 著者 | Shao, S, Murray, J, Brown, A, Taunton, J, Ramakrishnan, V, Hegde, R.S. | | 登録日 | 2016-10-02 | | 公開日 | 2016-11-30 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Cell, 167, 2016
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8DVM
 | | Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.6 | | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Thakur, A.K, Liau, N.P.D, Sudhamsu, J, Hannoush, R.N. | | 登録日 | 2022-07-29 | | 公開日 | 2023-03-29 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/ beta-Catenin Signaling via LRP6 Coreceptor Clustering.
Acs Chem.Biol., 18, 2023
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4EIR
 | | Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases (PMO-2) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, GLYCEROL, ... | | 著者 | Li, X, Beeson, W.T, Phillips, C.M, Marletta, M.A, Cate, J.H. | | 登録日 | 2012-04-05 | | 公開日 | 2012-05-23 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases.
Structure, 20, 2012
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5M29
 | | Structure of cobinamide-bound BtuF, the periplasmic vitamin B12 binding protein in E.coli | | 分子名称: | COB(II)INAMIDE, CYANIDE ION, GLYCEROL, ... | | 著者 | Mireku, S.A, Ruetz, M, Zhou, T, Korkhov, V.M, Kraeutler, B, Locher, K.P. | | 登録日 | 2016-10-12 | | 公開日 | 2017-02-08 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F.
Sci Rep, 7, 2017
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8E17
 | | BRD4-D1 in complex with BET inhibitor | | 分子名称: | (4P,6M)-6-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl]-4-[5-(methanesulfonyl)-2-methoxyphenyl]-2-methylisoquinolin-1(2H)-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 | | 著者 | Gorman, M.A, Fitzgerald, C.G.D, White, J.M, Parker, M.W. | | 登録日 | 2022-08-09 | | 公開日 | 2023-03-29 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography.
Chem.Commun.(Camb.), 59, 2023
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